Saturday, June 22, 2013

EXCLUSIVE : The What & The How of DHT (Dihydrotestosterone) in the Brain

Having trouble reading this post due to the Colors or layout? CLICK HERE for the "LightPortal Version" which will be easier to read and has a lighter background, you can also get there by going here -->  http://area1255-lightportal.blogspot.com/2016/06/exclusive-what-how-of-dht.html


Many bodybuilders and fitness enthusiasts are going to be thrilled to find out how exactly DHT works in the Brain. What does it do for us there ? Is it really responsible for libido, and if so, what other chemicals does it affect? This article aims to surpass and explain the general knowledge floating around on the Internet and on Forums. I am not a doctor, but I have compiled a nice bunch of references and studies to cite the foundation of this article. I also will explain briefly (an estimate) how someone would feel based on the relative changes due to DHT - discussed in this article.

First off, a basic explanation of DHT (Dihydrotestosterone); it is an androgen (male sex hormone), like Testosterone, which rather than promoting the growth of muscle mass directly (tissue-acting), it acts via intracellular (in the cell) mechanisms to increase strength and metabolism. DHT is not very anabolic, but it is Androgenic, and thus meaning, it promotes masculine characteristics (such as a deeper voice, and growth of facial hair, body hair etc) (1).  DHT has a bad rap, since it has been claimed to cause an enlarged prostate, but if you follow the source, *most* of the studies saying this are linked to pharmaceutical promotion of their anti-prostate, anti-Male drug, Finasteride (Propecia) and Dustasteride(2) (3).  DHT has also been claimed to cause your hair follicles to become thin, and your hair - subsequently falls out. No. Just No. DHT has been implicated as a factor at most, more studies show that more specifically it is Zinc deficiency AND genetics that provoke male pattern baldness (4)(5).  Although Zinc deficiency causes the rise of DHT levels, it also causes increases in prolactin, and estrogen, thus the real problem here *could* have to do with either of those hormones. Just to clarify, Anti-ESTROGEN drugs have been used recently to treat prostate enlargement (BPH), and they are very successful, with less side-effects(6) (7) (8) (9). So if they were wrong about DHT causing prostate enlargement, maybe they were wrong about DHT and hair loss too.

      DHT - HOW IT AFFECTS THE BRAIN - AND NERVOUS SYSTEM



But anyway, we got carried away. Let's go on to discuss DHT's effects in the Brain.
DHT has pronounced effects on neurochemistry (it affects neurotransmitters in the brain). DHT has been shown to increase circulating epinephrine levels (adrenaline), this can cause anxiety in predisposed individuals, however, most of the time, this is not the case, since DHT also increases GABA activity in the brain, which is relaxing (10) (11) (12).   So in other words, DHT should promote A focused, calm burst of energy, which is what many users of DHT-based steroids, report as the "alpha-male" feeling (13) (14).  Dihydrotestosterone increase central and nervous system energy production by increasing not just adrenaline, but cyclic AMP (15). This molecule increase thermogenesis (fat-burning and heat production)(16).  Cyclic AMP facilitates the conversion of TSH thyroid hormone, to T4, a more potent thyroid hormone, thus, indirectly, DHT increases thyroid function (by increasing cyclic AMP) (17).

So seeing all this, DHT definitely acts as a nervous system stimulant, and a metabolic "probe", it also increases GABA.  Second to this though, it could indirectly decrease serotonin or serotonin receptors; since DHT antagonizes estrogen activity, and estrogen helps maintain the expression of serotonin receptors in the brain(18) (19). This is also consistent with DHT being shown to stop estrogen induced prolactin release(20)
This is part of the reason behind using DHT Gel to treat gynecomasita.  Clearly DHT has anti-depressant effects, since Finasteride causes depression (21) and also based on the above mentioned activity of DHT in the brain. It gives energy, it gives focus, it gives aggression. 

DHT also improves spatial working memory(22), according to some studies, by altering NMDA-receptors(2
3) (namely increasing), and by improving Calcium-induced acetylcholine release & function in the hippocampus(24)(25); a very important area of the brain involved in memory formation and spatial (directional) memory.

DHT also decreases glutamate levels and excitory outputs through other mechanisms (26) (27) (28).


Finally, Dihydrotestosterone, or it's metabolite 3-alpha-Diol; downregulate alpha-adrenergic receptor distribution, leading to more inhibitory adrenergic (adrenaline influence)(29) (30) (31). For those who don't know, adrenaline can activate an 'alpha receptor' - which stimulates the nervous system, vasoconstricting blood vessels and arteries, raising blood pressure, or it can activate a beta-adrenergic receptor, generally vasodilating artieries, but yet, increasing heart contractile force. This all might just be another result or a reflection of what is mentioned above, that DHT increases epinephrine, GABA, and cyclic AMP.  However, in a separate study, Testosterone (without specificity), had upregulated alpha-1-receptors to protect the heart against ischemia(32).  Is this an effect of Testosterone or it's metabolites though. Likely, it doesn't matter, it was probably case coincidental, but may indicate that if blood pressure falls too low, Testosterone can increase it to maintain homeostasis.

In yet another study however, DHT has been shown to increase alpha-1-adrenergic expression, whereas Estrogen decreased the expression/density
(33).
This again reflects the need for DHT and Estrogen to be kept in balance, as both promote vasodilation through different pathways, however, since Alpha-1-receptors are incredibly potent Vasoconstrictors, DHT + an OVERALL deficiency in nitric oxide may actually promote high blood pressure, especially in coordination with estrogen deficiency. Interestingly, Alpha-1-receptor activation may increase serotonin activity at the 5-HT1A receptor(34)(35), this is an auto-receptor that ironically seems to possess anxiolytic (serotonin-typical) effects. 5-HT1A activation has shown to help social anxiety disorder, but worsen anticipation anxieties(36)(37).
In another study, DHT/Androgens also facilitated serotonin 5-HT1A/1B agonist-decreases in aggression, which is controversial, although it appears that estrogen allows for intermale aggression by downregulating serotonin 5-HT1A/1B activity(38)(39). Thus DHT's only pro-aggressive propertly lies in it's adrenaline promoting effect, and not with serotonin.


       OTHER CENTRAL AND MOLECULAR CHANGES INDUCED BY DIHYDROTESTOSTERONE

  1. Dihydrotestosterone appears to strongly increase MAPK; Mitogen-Activated-Protein-Kinase - this leads to a plethora of central and molecular changes as well as genomic/expressional changes(40)(41).
  2. This action further reinforces and validates DHT's suppressive effects on serotonin systems (42) since activating MAPK leads to increased serotonin transporter (SERT) activity - an effect directly opposite of SSRI's (43) (44) (45)




So DHT via multiple pathways increases nervous system strength, DHT increases epinephrine levels, decreases prolactin (assuming you have enough dopamine production as well), increases GABA, may decrease serotonin and serotonin receptors. All-round this means DHT has positive effects on your chemistry and nerve cells. By reducing prolactin, and estrogen, and subsequently serotonin, and also regulating catecholamines, by this, DHT can definitely increase libido, and alleviate sexual anxiety in most individuals by increasing GABA. DHT is key to many of Testosterone's brain benefits. Keep in mind though, despite positive effects on brain chemistry, this still doesn't give an excuse to OD on aromatase inhibitors, likely, because you need a little bit of estrogen (not much at all), to promote nNOS (neuronal nitric oxide synthase) production. So DHT serves as a great compliment to a little bit of brain estradiol, and a great ratio of DHT to estrogen means optimal sex drive, stamina, charisma and general masculinity.


Let's summarize in Bullets Here.

  • DHT regulates alpha and beta adrenergic receptors.
  • DHT may increase alpha-1-receptor density.
  • DHT may decrease glutamate activity and increases mGLU7 expression (which increases GABA release)
  • DHT increases serotonin 5-HT1A receptor density by influencing A1-Adr.Receptors.
  • DHT promotes serotonin 5-HT1A/1B activity and may reduce aggression in the presence of serotonin. Although this may easily be over ridden by the pro-adrenergic effects of DHT.
  • DHT increases beta-endorphin release by ^ 5-HT1A receptor indirect activation.
  • DHT facilitates the release of Epinephrine (adrenaline).
  • DHT increases cyclic AMP.
  • DHT blocks estrogen-induced prolactin release.
  • DHT reduces serotonin and serotonin receptors by inhibiting estrogen influence in the Brain. (but mainly acting to oppose 5-HT2A,2C and 5-HT4 receptors)
  • DHT increases Mitogen-Activated-Protein Kinase (MAPK) which leads to a variety of molecular changes and genomic changes as well as neural-changes; decreased serotonin activity in the brain and periphery. 
  • DHT increases GABA and GABA-A (neurosteroid-specific) receptor expression. 
  • DHT increases NMDA-receptors in the Hippocampus.
  • DHT increases Ca3 (Calcium) evoked Acetylcholine Function(AcH release).
  • DHT increases nervous system strength and regulates blood pressure.



This article has been Written BY : AMxProd    & Reviewed by  : D.Shiva
BUY THE MOVIE "THE IMMORTALS" FOR CHEAP HERE 
                                               

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Thursday, June 20, 2013

How to Reduce Prolactin mRNA With Supplements (not just altering level of)

Having trouble reading this post due to the Colors or layout? CLICK HERE to go to the "LightPortal Version" of Area-1255 or simply go here --> http://area1255-lightportal.blogspot.com/2016/06/how-to-reduce-prolactin-mrna-with.html

HOW TO REDUCE PROLACTIN mRNA
What Supplements Will Do This - BY:AMxProd


Most of you involved with Bodybuilding and Fitness, probably study a whole lot of sex hormones, steroids/neurosteroids, proteins etc.  For those who don't know, prolactin is a hormone that 'regulates' your testosterone production, as well as dopamine production - both testosterone and dopamine, are important neurohormones that help to improve quality of life, enthusiasm, motivation and sex drive.  Those who have studied prolactin reducing supplements, will find ways to reduce how much prolactin is produced, usually by increasing dopamine - supplements like L-Dopa, or ginkgo biloba do this But how do you actually reduce receptor and mRNA concentration, so that prolactin can't bind to it, and can you cause permanent decrease of prolactin activity this way ?  Yes.

A Multitude of Studies have emerged that show the Supplement - Royal Jelly, can decrease significantly, the prolactin mRNA, leading to long-term increases in pituitary weight (1) (2). This results in higher testosterone, dopamine, and subsequently; better quality of life, a higher libido, and better strength in the gym.  Royal Jelly has also been shown to increase brain neurotrophic factor, and glial cell neurotrophic factor(3)(4)(5). These enzymes, increase dendrite growth and rejuvenate your brain cells and production of new cells in the reproductive organs, of both men and women.  Important because, this causes growth of erectile tissue, and can be used in synergism, with other growth promoting supplements, and would be perfect along with nitric oxide supplements for penis enlargement.  

Royal Jelly has also been shown to increase energy production and thermogenesis (fat-burning) through the modification of an enzyme called - TRPA1(6).  This means there are multiple mechanisms by which Royal Jelly has benefits for general health. It acts to preserve and restore youthfulness, by rejuvenating the pituitary gland naturally. It acts to modify specific enzymes to restore general health.

So this may be one of the greatest breakthrough products for those who don't know. If you feel the urge to pick up some Royal Jelly, the one combined with honey tastes very good, it can be put on Bread or toast, used as an ingredient in pies. I enjoyed this product very much - Royal Jelly in Honey. You can of course, do your own research first, I would never advocate not doing the research, but it is all in this article, and keep in mind I would never try a supplement, without doing proper research on it first.  So yes, read the studies, and then when you decide, enjoy, you will be amazed what this single supplement can do.


Here is the Link Again To the Product I recommend. -------->Organic Royal Jelly in Honey

The product is only 12.00!
YS Royal Jelly/Honey Bee - Royal Jelly In Honey Ultra Strength, 21 oz gel



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Tuesday, June 18, 2013

AI Sports Nutrition - Massularia - INDEPENDENT REVIEW

Having trouble reading this post due to the Colors or layout? CLICK HERE for the "LightPortal" Version of this post or simply go to --> http://area1255-lightportal.blogspot.com/2016/06/ai-sports-nutrition-massularia.html

OK. So it seems the fitness world is lacking a real, independent review of AI Sports Nutrition - Massularia.  One whom is not sponsored, given free bottles, or coerced in any way. That'd be me. I have been into fitness and bodybuilding for over 10 years. I have worked at the BAC (Buffalo Athletic Club) for 4 years.  I know what to expect from these so-called "test-boosters". I know how people come in and rave about the products, and I know based on their training (generally), if what they speak about, results wise, is even nearly close to the truth. 

The amount of Reps, Paid and Sponsored loggers, and over-advertising for supplements is disgusting. 
I have seen many people deceived by products that don't work for them. It's my goal to ensure you a real and legitimate, 100% honest review. In which all negatives, are clearly spoken of. If I feel the product is shit I will tell you.


On to this, AI Sports Nutrition - Massularia. Massularia is an shrub which grows in Western Africa, the stem is chewed on to prevent gingivitis and kill already residing bacteria in the gums. It also was chewed for an aphrodisiac and fertility boosting effect.  Some studies back both of these facts up (1) (2) (3).

But does this definitely translate to humans, and how much of a dosage should be used ?

Appears it would, namely at 250mg/kg; many people claim to be seeing results from it. There seems to be a lot of people who stand by products with this ingredient. But as in the Case of A Massularia only product, with no other ingredients, does it work. 

Here's my review/log on AI Sports Nutrition - Massularia.


First off, the product can be expensive. Especially off bodybuilding.com - it is 39.97. On bodybuilding warehouse, only 31.45.  If you take two in the morning and two in the evening (4 a day), the bottle will last you a month exactly.  

During the course of the bottle I had noticed some interesting effects.  It seems like my body was getting warmer after taking it the first time, bout an hour after, I had an un-usual burst of energy, and an amplified drive to work out. I really questioned whether, one dose, could have that effect. So I kept taking it. By day 3, I was finding it a bit hard to sleep at night, I would much rather go for walks all throughout the day and night, I had a relentless compulsion to stay active. When I did sit down, the first thing on my mind, was getting everything and more done, from the day before, that wasn't finished. The sense of focus was enhanced, I wasn't as easily distracted for some reason.

Day 5, I am now noticing, a very intensified libido and sensitivity. So much that all it takes is to look at a real hot chick in the store for one half of a second, and get instant wood. At the same time, as mentioned before, there is warm sensation throughout the body, as if there heat eminating from my pores (which there is). The sense of vitality is just amazing.

Day 6, completed a full workout, 1600 push ups, 5 sets of curls, free weights, and 500 sit-ups. The pump was noticeably better, and still that warm sensation going through my body. Sense of focus is going strong as a bull.  Only downside is I am only getting 4 hours of sleep per night.  

Day 14 - Starting to notice compositional changes, veins are poking out more, all across my frame, and I lost 2.5 pounds in fat. Getting some gains in my arm width as well, and just feel great.


Day 20- I'm not sure if the effects are starting to wear off a little or what, but these last couple days, I've been feeling a little tired, and the warm sensation is hardly noticeable, the last few days though, sleep has been better. I have been getting 7 hours of sleep as opposed to the initial 4, which admittedly, is a little bit disturbing.

Day 30 - In the past 10 days, and in finishing the bottle, I summarize my experience with this product. Here is my conclusion.


  1. Product gave noticeable "warm sensation".
  2. Product sky rocketed libido and sensitivity.
  3. Product increased sense of focus and vitality.
  4. Product made it hard to sleep for a little while.
  5. Product increased strength and vascularity, while decreasing body fat.



 PRODUCT REVIEW BY : D.SHIVA





Friday, June 14, 2013

Where to Order DHT Gel Online (Buying Andractrim Online) (& Product REVIEW)

Having trouble reading this post due to the layout or colors? CLICK HERE for the ''LightPortal'' Version.


-->"BUYING DHT CREAM/GEL ONLINE"<--
*QUICK AND SIMPLE*
REVIEW OF PRODUCT LEGITIMACY
    AND OF PRODUCT QUALITY
 

So there are sites online claiming to sell you DHT creams/gels, most of which advertise "Andractrim Brand Gel". Now for some, these products may look sketchy, and I admit, even I thought the same thing at first.  But in doing a simple price check, these gels should run you between $80$ USD - and 120 $USD$. If you calculate the costs of bulk drostanolone (DHT) powder and the transdermal solution. Fortunately, many of these sites, though slightly more expensive, are still reasonably on point with the proper cost of the items and production. 

Which site can you get Real DHT Gel at ?


RIGHT HERE

(Click on "Right Here" Above Then Go To Testosterone Gel)
And, have I used this product ?


I HAVE. It is a great product, and although it takes time
(a couple weeks) to work, it will do wonders in helping you achieve your workout goals, and it will cure gyno fairly quickly, but you must work out (preferably push ups) for maximum effect. For PE (Penis Enlargement) it can have a positive effect, but again, working out, and eating right will maximize the effect. When you begin the order process, they will ask you some questions related to your health. You can answer them honestly, but to prevent any cautions/delays from them sending the product (you don't need a prescription though), you might want to just say you have no health issues. The shipping is pretty quick. If you are in the USA, expect about 1 or 2 weeks max, after it ships (first orders take 1-3 days to process), to receive the item.
Again, this is no-prescription DHT Gel. It works. It is legitimate at this particular site/clinic, I can't really say for other sites, but this one in particular is real and they get it done.



REVIEWED BY : D.SHIVA
APPROVED BY and SCREENED BY : M.Binakaveru

(AREA-1255)   "The last of the Honest Bloggers"  (AREA-1255)
(AREA-1255)


Thursday, June 13, 2013

List of Oxytocin Suppliers / Where to Buy Oxytocin Spray Online

OXYTOCIN
List of Oxytocin Suppliers / Where to Buy Oxytocin Spray Online
Personal Compilation - REVIEW & PUBLISHED BY: The HexOmANSiR

Oxytocin is a hormone and neuro-modulator/neuropeptide which has important roles in many physiological functions. It regulates emotions; specifically - bonding, trust, anxiety, fear, aggression.
Oxytocin's potential benefits are...
  • Decrease in Social Anxiety Symptoms
  • Increase in Empathy 
  • Reducing Paranoia
  • Increased Orgasms/Orgasmic Intensity (men & women)
  • Increased Mental Clarity

There are three methods of absorption/drug delivery, and thus three different oxytocin products. You can use a nasal spray containing oxytocin, you can, you can use a pheromonal oxytocin spray, which indirectly, will be inhaled and affect your partner as well. You can also buy injectable oxytocin, which you would inject subcutaneously and it acts quicker. Oxytocin is safe in recommended doses, and has low toxicity. 



Oxytocin Products


"Oxytocin Factor" Oxytocin Spray
This oxytocin product is a nasal spray (intranasal oxytocin), and is quite effective. My wife and I have used it before and the effects are very pleasant. It seems to really increase passion in our lives, even after a bad day. My enthusiasm is much higher while using this product and I feel no longer "tied down", I feel more open, collected, and focused. Thoughts flow much clearer, no doubt. Anyway, it's kinda expensive for the amount you get. But the effects are there, and although there are a few who have suppossedly gotten nothing out of this product, I of course, do not know what their lives entail. Just remember that you need to achieve a state of balance for this to work, and be patient, its not a 10-second cure.


Vero Labs "Liquid Trust" Spray (now called CONNEKT/ATTRAKT)
Liquid Trust can be sprayed anywhere, it has no odor to it, except maybe a slight "rubbing alcohol" smell. It can be used to generate a peaceful environment along with other natural air fresheners, it seems to work well in combination with Vanilla Aromatherapy Spray and Lavender Spray.  Thank God for Synergism ;)
Spray this on yourself, and I can tell you First-Hand, people will open up to you out of no where, you instantly become this person people can confide in. You are literally altering your aura, and people sense you as safe to be around. This spray is great for you and your partner to restore bonding, and trust, and thus honesty.  It really helps refuel relationships. 




Oxytocin Injection (Research Chem Form)

And this, is the third form of oxytocin supplement, you would need to buy the research chemical, dilutents, syringe and needle etc, all separately. It's a pain, but subcutaneous injection almost guarantees effectiveness. Injections bypass the liver and act almost immediately. I have never used this form yet, but I plan to. When I do, I will update with results.  Peptide is purchasable here and here.

Also find it in Google Search "oxytocin peptide research chemical buy".


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5 Ways to Speed Up The Tanning Process

ANOTHER REVIEW BY D.SHIVA ? IT CAN'T BE ! 
According to Those Who Know D.Shiva, "Yawl Pretty Surprised".
I've been Still in my Work On The Crew's Home Page.
Not. I Lied.
I've been Lazy, So  Guess I Compensate by Writin On Here -_-

Anyway, this article includes 5 Ways to Speed up the Tanning Process and it Describes Chemicals to Induce Tanning (Pigmentation).  Keep in mind, not all of what I mention is "Chemical". I mention Diet too!

Let's get Tanning !

                                              [ Idol Tan Sunless Tan Lotion ]

This is a very well formulated tanning lotion, and I've used it on three different occasions as well as close friends of mine have. It is potent and you don't need to use a whole lot, but the results work pretty quickly. This is a lotion that will get you tan, it is not junk, bunk or pure hype. Because I have seen it work and on myself and many others. If you apply it daily, stay out in the sun for about an hour at least, this will accelerate the tanning process.
     
                                       

                     THIS IS WHERE YOU CAN ORDER IT


                                             [ Melanotan & Melanotan II ]
The second way you can speed up the tanning process, is by using a nasal spray of the Chemical Melanotan or Melanotan II. Studies have shown this chemical to be very effective in regards to increasing pigmentation (1) (2).
  Melanotan is also identified as a chemical that can reduce body fat and suppress appetite (3).  You can buy these chemicals legally on www.magicskinsolutions.com !


                                              [ Atomic Meltdown 'Lotion' ]

You can also accelerate the tanning process by directly applying a transdermal lotion (supplement) known as Atomic Meltdown. It works both as a tanning agent and a fat burner. Apply it on your abs, on your face, on your Arms, back, wherever. Personally I can tell you - me and my buddies have used this before when we were in London, and it worked very very well ! Within a week all of us noticing more pigmentation. Of course, it was real hot and sunny over there too, hard to get away from. 

--------------------------> Atomic Meltdown Lotion Can be Found HERE <-------------------------


                                            [ Work Out and Eat "Right" ]


Numerous studies have highlighted the importance of a chemical called "cyclic AMP" in the process of pigmentation (1)(2). Aerobic exercise increases levels of this chemical in the body, by increasing adrenaline, which then tells the body to increase this thermogenic and pigmentating hormone(3) (4).

Additionally, eating more protein increases the level of this chemical - cyclic AMP(5).



                                      [ Take Forskolin Supplements ]


Forskolin is a compound that activates Adenylyl Cyclase, which increases cyclic AMP (intracellular - in the cells), as said and sourced above, cyclic AMP accelerates the pigmentation process and helps you get tan quick.  Forskolin has valid studies for this application as well, but you should use it in a cream form (1).  Also I have not used pure forskolin cream before, but it is included in Atomic Meltdown formula listed above, and I have used that, as well as Idol Tan, and they both include Forskolin and Work !

But I can't say for sure it's the forskolin doing all the work, but it certainly looks promising based on studies and user feedback (2) on pure forskolin products. 
You can get Forskolin Cream Below

____________________________________________________________

                                            



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Saturday, June 8, 2013

(TRANSFORM) Forged MHO Poppers Review (TRANSFORM)


ForgedMHO Poppers Review      BY : D.Shiva                      

4.5/5 Review of TRANSFORM's MHO Poppers Anti-Estrogen



Secret Agent Ninja Blade Review

AMxProd (AMxReborn) is Here with a 2 minute, Straight to the Point Review on the Secret Agent Ninja Blade, or Secret Agent Tactical Ninja Sword. 


Video is up there but here is my Write-Up. 

The Secret Agent Ninja Blade (Tactical Ninja Sword) is purchasable on Budk.com, Amazon of course, and many other sites. It measures 27" all together but The main part of the blade measures about 14", the teeth on the middle of the blade are very sharp, but the Tip is factory sharpened. I mean, really the whole thing is factory sharpened but for some reason the teeth seem sharper than the tip.  The blade is stainless, black tinted steel, and it is very durable, with a comfortable handle and grip.  It is great for the price (14$-23$, depending where you get it).  If you swing it properly, it will chop plastic bottles right in half, and it will easily pierce cardboard and stuff like that.  This blade looks very nice and it comes with a sheath and a velcro band to lock it in, it also has a shoulder strap that is adjustable. Just be careful how you insert the blade back into the sheath when you are done, because it can easily rip through the sheath, and the sheath clearly is not metallic.  In my opinion, that is the only thing that could have been better about this product, but all round for the price, it's pretty good.  I like it and would recommend it to anyone.