tag:blogger.com,1999:blog-9158169732362839786.post4056644777994522220..comments2024-03-13T00:23:20.750-07:00Comments on Area-1255: The Third Bride; Explaining How Progesterone Works in the Brain (Progesterone Influences on Neurotransmitters/Synaptic Function)Jason Malek Russohttp://www.blogger.com/profile/13484819788942297056noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-9158169732362839786.post-71747882217977832052017-07-06T12:34:14.791-07:002017-07-06T12:34:14.791-07:00If 5-HT2A is ''supersensitive'' th...If 5-HT2A is ''supersensitive'' then you will have increase in Prolactin and Cortisol. But 5-HT2A is a tricky receptor, because if it is stimulated too much (by serotonin or others) then it ends up decreasing (downregulating).<br /><br />5-HT2A is a pro-emotional receptor, whereas 5-HT1A decreases emotions. <br /><br />Also, to go back to the appetite topic.<br /><br />5-HT4 receptors are interesting and totally unique, they increase Cognition and Memory, but they also increase stress in response to low food. So if you have less than adequate food supply and 5-HT4 is activated, you have more stress than someone with less activation of that receptor. 5-HT4 is also linked to primal aggression relating to food, as in battling the next person for food. So in poverty, serotonin probably plays a pro-aggressive role. <br /><br />--> https://www.ncbi.nlm.nih.gov/pubmed/15146954<br />--> https://www.ncbi.nlm.nih.gov/pubmed/14724239<br />--> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604225/Jason Malek Russohttps://www.blogger.com/profile/13484819788942297056noreply@blogger.comtag:blogger.com,1999:blog-9158169732362839786.post-65663315234601899012015-10-13T01:17:26.801-07:002015-10-13T01:17:26.801-07:00Thanks for that study! I'll add it in soon. Al...Thanks for that study! I'll add it in soon. Also thanks for joining the forum; we need some bright minds around there. :)Jason Malek Russohttps://www.blogger.com/profile/13484819788942297056noreply@blogger.comtag:blogger.com,1999:blog-9158169732362839786.post-61601615463403324632015-10-12T23:37:12.763-07:002015-10-12T23:37:12.763-07:00Progesterone regulates gamma-aminobutyric acid B (...Progesterone regulates gamma-aminobutyric acid B (GABAB) receptors in the neocortex of female rats.<br />http://www.ncbi.nlm.nih.gov/pubmed/8842381KPavelhttps://www.blogger.com/profile/08681884448629113135noreply@blogger.comtag:blogger.com,1999:blog-9158169732362839786.post-3929632324561423322015-09-24T16:00:32.002-07:002015-09-24T16:00:32.002-07:00Article is almost finished btw!Article is almost finished btw!Jason Malek Russohttps://www.blogger.com/profile/13484819788942297056noreply@blogger.comtag:blogger.com,1999:blog-9158169732362839786.post-86835178366476983152015-09-24T09:25:12.650-07:002015-09-24T09:25:12.650-07:00And for the 5-HT1A question - yes, that's true...And for the 5-HT1A question - yes, that's true, low estrogen especially if combined with low cortisol amplifies the expression of 5-HT1A - this can be good or bad, depends on the person; it certainly leads to less serotonin release by a variety of pathways..but if your E2 levels are low I would recommend mildly increasing them (only if deficient) by using NMDA agonists like D-Aspartic Acid..also low E2 tends to create most of it's side effects by diminishing glutamate transmission so most of those issues come from the striatal membranes and GPCR's located there. Contrary to popular belief though, E2 isn't strictly 'needed' for male libido or sexual function - but it does contribute by said pathways...it depends on the person - some people are very susceptible for even minor decreases in nitric oxide and such - and these types of people are likely to feel the 'crash and resolve' from even minor decreases in estrogen.<br /><br />http://www.psyneuen-journal.com/article/S0306-4530(10)00018-1/abstract?cc=y=<br />http://www.nature.com/npp/journal/v27/n1/full/1395866a.htmlJason Malek Russohttps://www.blogger.com/profile/13484819788942297056noreply@blogger.comtag:blogger.com,1999:blog-9158169732362839786.post-57730127821262636542015-09-24T09:19:43.672-07:002015-09-24T09:19:43.672-07:00As far as Vitex, I'm not sure how exactly it d...As far as Vitex, I'm not sure how exactly it depletes serotonin levels but it could be due to it's selective interaction with brain endorphins/opioid peptides...some opioid receptors when activated decrease serotonin and others increase it. <br /><br />http://www.ncbi.nlm.nih.gov/pubmed/11081988<br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993511/<br />http://www.ncbi.nlm.nih.gov/pubmed/1375724Jason Malek Russohttps://www.blogger.com/profile/13484819788942297056noreply@blogger.comtag:blogger.com,1999:blog-9158169732362839786.post-46608239641516086002015-09-24T09:16:02.626-07:002015-09-24T09:16:02.626-07:00Serotonin causes appetite suppression (anorectic) ...Serotonin causes appetite suppression (anorectic) effects by 1A, 2C, 4A receptors...so in theory, Lysine, Agomelatine and WAY 100 635 should abolish the appetite suppressant effects of serotonin - my feeling is the 5-HT4 receptor is more potent than the 1A in this regard but less potent than the 2C. This is also consistent with serotonin's ability (perhaps opposite) to INCREASE histamine by the 4A receptor but decrease it by the 2A receptor....<br />http://www.researchgate.net/publication/221694043_The_5-Hydroxytryptamine4_Receptor_Agonists_Prucalopride_and_PRX-03140_Increase_Acetylcholine_and_Histamine_Levels_in_the_Rat_Prefrontal_Cortex_and_the_Power_of_Stimulated_Hippocampal_Oscillations<br /><br />Jason Malek Russohttps://www.blogger.com/profile/13484819788942297056noreply@blogger.comtag:blogger.com,1999:blog-9158169732362839786.post-48236444889994352752015-09-24T05:24:23.074-07:002015-09-24T05:24:23.074-07:00www.idosi.org/wjdfs/wjdfs7(2)/7.pdf
Are there any ...www.idosi.org/wjdfs/wjdfs7(2)/7.pdf<br />Are there any such graphs for vitex?<br />Ashwagandha can increase prolactin in HIGH doses?<br />Has effect on D2 (Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats.)///KPavelhttps://www.blogger.com/profile/08681884448629113135noreply@blogger.comtag:blogger.com,1999:blog-9158169732362839786.post-8333438014743044812015-09-24T04:38:04.657-07:002015-09-24T04:38:04.657-07:00You also mentioned that low estradiol has correlat...You also mentioned that low estradiol has correlation with upregulated 5ht1a. And study "Possible Modulation of the Anexiogenic Effects of Vitex Agnus-castus by the Serotonergic System." proposes vitex has synergy with 5ht1a autoreceptor antagonists.KPavelhttps://www.blogger.com/profile/08681884448629113135noreply@blogger.comtag:blogger.com,1999:blog-9158169732362839786.post-90880908757182099632015-09-24T04:23:45.824-07:002015-09-24T04:23:45.824-07:00Inhibit-P contains 300mg of vitex. Vitex is rumore...Inhibit-P contains 300mg of vitex. Vitex is rumored to increase prolactin in low doses. <br />PMS girls like this herb. Does that all mean that initially vitex has serotonergic effect, especially at 5ht2a receptor. But then its effect on dopaminergic neurons is much more powerful. It is said vitex lowers serotonin. Which way? This study (http://www.ncbi.nlm.nih.gov/pubmed/11081988) says it doesn't influences mush on serotonin reuptake (but vitex was shown to increase serotonin standard metabolite measured in labs). And strange thing: I read 5ht2a can increase D2? Or it does that independently? If 5ht2a is supersensitive is it still prolactinergic?KPavelhttps://www.blogger.com/profile/08681884448629113135noreply@blogger.com