tag:blogger.com,1999:blog-9158169732362839786.post8230151213989356477..comments2024-03-13T00:23:20.750-07:00Comments on Area-1255: How to : Treat Anti-Psychotic Induced Weight Gain (Reverse / Prevent AntiPsychotic Weight Gain)Jason Malek Russohttp://www.blogger.com/profile/13484819788942297056noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-9158169732362839786.post-39134293081310907502015-09-22T07:26:18.674-07:002015-09-22T07:26:18.674-07:00Technically, betahistine and other H3R antagonists...Technically, betahistine and other H3R antagonists may indirectly enhance hormone function. However, because H3R's are lesser so in the hypothalamus than say the , the H1's - you are more likely looking at an enhancement in gonadotropin and central nitric oxide prodution. Prefrontal cortex contains a lot of H3 AND D1 - so the enhancement in dopaminergic function regarding that interaction is likely more so in the PFC and striatum. Thus enhancing motivation and attentiveness Upregulating D2 would help release oxytocin so it could help with pair bonding; the more dopamine; typically it's easier to engage in love and bonding. ... but it also depends on how much serotonin, glutamate , histamine and other factors. Ginkgo doesn't antagonize dopamine at all - but it does act as both a 5-HT1A agonist and a GABA-A antagonist; the latter property contributing to catalepsy and anxiogenic properties. If serotonin is high - it will reduce oxytocin by interacting with corticosteroid systems and inhibiting dopamine and glutamate by 5-HT2C, 5-HT6, 5-HT7 Jason Malek Russohttps://www.blogger.com/profile/13484819788942297056noreply@blogger.comtag:blogger.com,1999:blog-9158169732362839786.post-30418077852732096772015-09-21T23:40:51.241-07:002015-09-21T23:40:51.241-07:00So betahistine helps lower prolactin or what? From...So betahistine helps lower prolactin or what? From your blog I found that H1 upregulation increases prolactin release. But "Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function. " says H3 antagonism makes positive changes regarding D1(motivation) and D2. You mentioned D2 has bad sides. But some studies say upregulating D2 helps with internet|port addiction and pair bonding. Cabergoline agonizes it. <br />Also I found Ginkgo Biloba enhances catalepsy. Is that due to D2 and D1 reducing. So how really GB is able to reduce prolactin|increase dopamine?<br />Also may I ask additional question here? If serotonin is too high through desensitizing 5ht(1a) autoreceptor how it can reduce oxytocin from high histamine?KPavelhttps://www.blogger.com/profile/08681884448629113135noreply@blogger.com