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- Amphetamine's side-effects are related to it's ability to stimulate the CNS (Central-Nervous-System) . This is mainly related to it's adrenergic-actions (increasing/agonizing adrenaline receptors). Thus, alpha-adrenergic & beta-adrenergic stimulation contribute to Amphetamine's peripheral effects.
- Additionally, Amphetamine can stimulate Serotonin-release as it reverses the transport direction of ALL monoamine-transporters (not just Dopamine), Serotonin-activity at the 5-HT(2)A and 5-HT(4) Receptors contribute to the onset of Tachycardia, though, beta-adrenergic-receptors play a primary role.
- It is difficult to determine other than in a medical setting , how to appropriately attend to Amphetamine-side-effects. However, if you are using normal-therapeutic-dosages - then the best bet would be, assuming no other drug-interactions are involved , would be to counter the peripheral side-effects by limiting adrenergic-activity and RE-activity.
COUNTER-ACTIONS / REVERSAL OF AMPHETAMINE TACHYCARDIA
- DO NOT USE THESE AS A REPLACEMENT OF PHYSICIAN ADVICE AND UNDER NO CIRCUMSTANCES USE THEM AS A SELF-REMEDY IN SEVERE TACHYCARDIA!!!
- ONLY FOR USE IN MILD-TACHYCARDIA!
- MAGNESIUM (Liquid-Form) (Solgar is a good-brand, and tested in lab-analysis to contain the reported amount)
- L-Lysine (very high dose not required, but 4-6 grams AT LEAST). So at LEAST 8 normal 500mg capsules of Lysine.
- A mild PROcholinergic may help, something like Ashwagandha Extract (preferably a certified alcohol-diluted-tincture) - as Acetylcholine can help reduce excessive-heart rate...one or two or all three of these methods may be required, the lysine is less effective than the other two in controlling high heart rate...also, amphetamine depletes bodily levels of Magnesium - which further supports this hypothesis.
**SOURCES**
Adderall and cardiovascular risk: A therapeutic dilemma
MEDSCAPE : Amphetamine Toxicity
PUBMED/NIH :: Magnesium in drug dependences.
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Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine, d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan.
L-Theanine reduces psychological and physiological stress responses.
Barbiturate and amphetamine activity in rats fed a magnesium-deficient diet.
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MEDSCAPE : Amphetamine Toxicity
PUBMED/NIH :: Magnesium in drug dependences.
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Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine, d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan.
L-Theanine reduces psychological and physiological stress responses.
Barbiturate and amphetamine activity in rats fed a magnesium-deficient diet.
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Green tea is procholinergic. Actually, many common nootropics and common herbs are procholinergic. Just go on searching its name with " " and "acetylcholinesterase" "ncbi" in google
ReplyDeleteI know. There is an insane amount of herbs that possess AcHe inhibitor activities - however, their properties have to be balanced in order to obtain such a linear objective like 'counter-acting stim tachycardia'...or especially with something as strong as Amphetamine.
DeleteEXAMPLE: You wouldn't use an AcHe inhibiting herb that ALSO has NRI-properties and thus enhances norepinephrine and then hastening and worsening the tachycardia associated with amp.
For instance, Ginkgo Biloba extract would not be suitable for this purpose even though it raises acetylcholine - because it also increases norepinephrine and can antagonize/block GABA...so there is a difference between using ginkgo and amp or ashwagandha and amp..the latter will be successful in alleviating some anxiety and fast heart rate, the former may worsen it or even precipitate a greater manic reaction than with amphetamine alone...which, if you think about it, is the most common side-effect of amphetamine...mania. :)