List of 5-HT2B Antagonists Available As Supplements (Supplements that Antagonize/Block Serotonin 2B Receptors)

5-HT2B Receptors are a type of Serotonin Receptor (GPCR; G-Protein-Coupled-Receptor); they are evident mostly in blood vessels/human atrium (heart) (1) and in the small intestine (2) , however, they play a minor role in the ((CNS)), and activating them tends to increase serotonin release and blocking them reduces serotonin release {(3)}.

Applications and Benefits of antagonizing the Receptor would include.

• Improvement of Cardiac Function and Reduction in Blood Pressure [4]
• Alleviation of Chronic Diarrhea and other intestinal complaints associated with I.B.S. -(5)-
• Improvement in side-effects associated with SSRI-medications for Depression (particularly, bowel complaints) {6}
• Enhancement of Muscle Pump during Exercise ~{7}~
• Utility in k+-mediated- augmentations; to reduce the effects of SSRI's on Potassium-related depolarization and thus to enhance Potassium-electrical currents (K+).(*8*)
• Possible use, adjunct in Migraine treatment , lesser so than other uses, though. <(9)>
• Transient reduction in Plasma Serotonin level/s, and significant reduction in Serotonin Release. ~!(10)!~

The main TWO only EFFECTIVE Over-the-Counter 5-HT2B-Receptor Antagonists are.....

• GINGER (can be bought as Chewy Candies, Tea or Capsules, as well as Liquid Solution).
• YOHIMBINE (a stimulant supplement, used as a fat burner with aphrodisiac properties)