TNF or "Tumor Necrosis Factor" was discovered in 1968 & originally named Lymphotoxin by Dr. Gale A Granger of University of California [1]. Many other Researchers as well as Medical Professionals continued to look into the biological effects of this selectively cytotoxic protein until it was finally differentiated as TNF-A or tumor necrosis factor alpha. The other protein in the "TNF Family" is subsequently referred to as Lymphotoxin-Alpha or LTĪ± [2]. This is because TNF-a has distinct effects that are separate from LTa [3].
In recent days, TNF-a is often the target of research involving inflammation and for good reason; TNF-a produces most of the unfortunate bodily effects due to inflammation [4] [5]. Therefore TNF-a is of great importance in determining how to tackle inflammation and many drugs used to treat Rheumatoid Arthritis and other forms of crippling inflammation directly block or ''inactivate'' TNF-a [6] [7] [8] [9].
In addition TNF-a plays a key role in symptoms of viral infections [10] and as well as in states of internal distress [11], severe wasting states [12] and Cancer [13].
So now, if TNF-a levels are high for any reason, one would want to know what the ''symptoms'' would be...and if you have read the above you would know that TNF-a can be increased for a variety of reasons. Let's first go over those symptoms though.
Symptoms of High TNF-a levels would include.
- Nausea [13]
- Muscle Weakness [14]
- Loss of Appetite [15]
- Bowel Problems [16]
- Low Energy/Fatigue [17]
- Poor Memory (over time) [18]
- Low levels of Sex Hormones [19] [20] [21]
- Cardiovascular issues [22]
- Anemia [23]
- Depression [24]
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Now onto the REASONS for Elevated TNF-a.
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- Oxidative Stress and Poor Antioxidant Intake [25]
- Obesity/Poor BMI [26]
- Sleep Deprivation [27]
- Excessive Exercise [28]
- Vitamin & Mineral Deficiencies [29] [30] [31]
- Bacterial or Viral Infection [32]
- Influenza ("the Flu") seems to increase TNF-a levels and this causes the symptoms associated with the Flu [33].
- Hepatitis C seems to cause activation of the TNF-a system [34].
- Acute HIV Infection [35].
Now, how do we INHIBIT or REDUCE the amount of TNF-a in our body?
- The easiest way is by supplementing with a HIGH-POTENCY Turmeric / Curcumin Extract [36]. I recommend Barlowe's Turmeric Extract. It has an extremely high level of the most effective component of the spice; Curcumin in the extract, close to 90%.
Other Suggestions such as by Life Style changes are many. I recommend reading SelfHacked's section on this.
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