"Cypro-Crash" or Cyproheptadine Crash and Cyproheptadine Tiredness/Lethardy (How to COUNTER-ACT/BLOCK Cyproheptadine Sedation 2018)

Cyproheptadine is an Anti-Serotonin, Anti-Histamine drug with many interesting properties. It is generally Prescribed for Allergies, Asthma, Dermatitis and other allergic-reactions. However, it is also (sometimes) used as an Appetite Stimulant - to improve Food Intake in those with Cancer or on Chemotherapy. It also improves Appetite in those with the Condition: Cystic Fibrosis [STUDY].

As discussed on Ray Peat forum, it can protect the Heart, Stimulate Libido (sexual desire), Treat/Cure SSRI-Sexual Dysfunction & PSSD - and can remarkably improve Energy Levels IF paired with Thyroid-Hormones; particularly T3 (Triiodothyronine). 

{ If you'd like to BUY Cyproheptadine you can Contact Me @ area1255x@gmail.com }

However, Cyproheptadine has unsavory Side-Effects including Same-Day Sedation [1] and "Next-Day-Sedation" [2], in many Cases, people get 'other' Disturbing Symptoms while taking Cyproheptadine to treat Hay Fever or other Allergic-Type Symptoms.

Some of the Symptoms associated with "Cyproheptadine-Crash" or Cyproheptadine Side-Effects include...

1. Night-Time Anhedonia (lack of Pleasure/Desire/Feelings) (if Cyproheptadine is taken in the Morning-Time).
2. Extreme Sedation and Low-Energy Levels.
3. Depression.
4. Anxiety.
5. Worsening of OCD Symptoms ESPECIALLY in those that also have ADHD or fall into the "Low-Stimulation" Type of OCD.

To Counter-These Side-Effects, we MUST Do The Following!

1. Take 200 MG of Caffeine with Cyproheptadine pills, this will help to counter-act some of the Sedation.
2. Take T3-Thyroid Pills (buy-here-with-discount), this will SKY-ROCKET Core Energy Production, Body Heat & Metabolism!
3. Use L-Histidine (2,000 MG or 2 Grams; 4 Capsules) + Kutaj Bark - these will help block anti-histamine Effects of Cyproheptadine - while PRESERVING the anti-Serotonin, Pro-Dopamine effects of Cyproheptadine.
4. Vitamin B12 can REVERSE Negative Effects of Histamine H2-Antagonists on Fertility, in Men - so taking a SHOT or BIG-DOSE of Liquid Vitamin B12 (Secret 12 is the Best Brand!) could help Repair Sperm Production in Men [STUDY].
5. Lastly...you can take an herb ALONE called "KUTAJ/KUTAJA" which is known by its botanical name: Hollarhena Antidysenterica - which contains Conessine; a Histamine-stimulator [Reference 1] [Reference 2].
6. By taking all of the above; Caffeine, T3, L-Histidine, Kutaj Bark Powder & Vitamin B12 - you can Effectively BLOCK/REVERSE Cyproheptadine's negative side-effects; such as Sedation and Emotional Numbness!

PHARMACOLOGICAL LESSONS IN CYPROHEPTADINE MECHANISMS

1. Cyproheptadine BLOCKS Histamine H(1) Receptors, that means it TRANQUILIZES the nervous system by reducing Histamine-related Voltage in the Brain [3] [4] [5].
2. Cyproheptadine blocks Histamine H2-Receptors [6], thus leading to Reduced Stomach Acid and Metabolism [7] [8].
3. Cyproheptadine blocks Acetylcholine [9]; a Neurotransmitter that increases Alertness & Attention [9] [10] [11].
4. Cyproheptadine, but not most other antihistamines (allergy-pills) blocks CALCIUM in the Brain [12]. This can lead to lower Blood Pressure and reduced Energy Levels [13].
5. Cyproheptadine & other AntiHistamines block Sodium Channels [14], mildly, which may also SEDATE the CNS - Central Nervous System [15]
6. Histamine helps to promote Brain Function by stimulating NMDA-Receptors [16] - thus, Cyproheptadine will DIRECTLY by means of blocking Histamine - cause reduction in Global Brain Function by reducing Glutamate-Responses, and firing.

Because of these Multiple Mechanisms by which Cyproheptadine can be Sedating, or Impairing - it is Crucial that one understands their own Biological Susceptibility. For example, if you have Prior taken some things to improve Brain Function - such as "Nootropics" or "Smart Drugs" - specifically things like Alpha-Brain - and you noticed a Night-and-Day Difference - then Cyproheptadine probably isn't for You.

If Benadryl [Diphenhydramine] causes you unbearable Sedation/Tiredness - then Cyproheptadine will *likely* be Worse. 

Those who react badly to antihistamines & Allergy-Pills in general, should not use Cyproheptadine.

Those with Food Allergies usually have HIGH Serum (Blood) Histamine and LOW Breakdown (bodily removal) of Histamine via LOW Diamine Oxidase levels (an Enzyme that Removes Histamine). Thus, taking Caffeine may be a *probable* DANGER for those with Food Allergies/Sensitivities.

Because GENES play a Substantial Role in Food & General Allergy Susceptibility - using a Genetic Screening Tool such as PROMETHEASE may be a Viable Option, better to be Safe than Sorry!

Genetic Factors in Histamine also control Asthma-susceptibility AND Severity!

Brain Histamine & Behavioral NeuroScience is a Research/Study Paper that talks about the Growing Wealth of Research involving Histamine in Behavioral Motivations (2018).

Miscellaneous Cyproheptadine Research & General Histamine Research 2018

EXPLORATION OF THE INTERRELATIONSHIP OF SEROTONIN WITH THE EPINEPHRINES AND HISTAMINE*

Pitolisant, an inverse agonist of the histamine H3 receptor: an alternative stimulant for narcolepsy-cataplexy in teenagers with refractory sleepiness.




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