Modafanil is a powerful waking drug that activates the Brains hypothalamus [1] to awaken the Mind, it causes Histamine (the "wake-up" neurotransmitter) to start firing [2] and activates the Histamine nerve channels [3]. It does this by disinhibiting Histaminergic neurons by reducing GABA activity; a "calming" neurotransmitter that reduces Histamine [4] & Glutamate [5] and promotes SLEEP.
Modafanil & its 'Brand-Name' Provigil also have Dopamine enhancing effects, through its interaction (inhibition) with the Dopamine Transporter (DAT), thus, it has effects *kind-of* in the same direction as Amphetamine & Concerta/Ritalin (methylphenidate) but is more "selective" for certain Brain Regions & locales (subpositions) of the Human Dopamine Transporter.
This Dopamine action of Modafanil may also promote Histamine release this way - as activation of D2-receptors increases Histamine release & firing of histamine neurons. Presumably by reducing cAMP, which is a second-messenger with anti-allergic & anti-inflammatory effects - working in an opposite direction to Histamine [Reference].
More evidence for HISTAMINE role in Modafanil is that in a Head-to-Head comparison with another Histamine releasing drug; a H3-antagonist which tells the Brain to "disable the breaks on Histamine neurotransmission" - they both had identical effects on EEG results & Power Spectra, proof that during Sleep Deprivation, even, these Histamine-based drugs are getting at the core of the issue [6].
Adrafanil also does all this, except Adrafanil is Over The Counter, Modafanil is [typically] Prescription only [7], although it can be Purchased without a Prescription on Naps Gear; The Internets Largest Underground Pharmacy, producing mostly Anabolic Steroids.
Even though Modafanil is used for Narcolepsy; its main approved use (medically) - it also is used for ADHD & ADD; Attention Deficit Hyperactivity Disorder [8] and Modafanil have a long history [9].
Adrafanil converts (turns into) into Modafanil, taken orally, effects for ADRAFANIL start as early as ~45 minutes [10], but on average Adrafanil kicks in within 1-2 hours (onset of effects) [11] [12].
Knowing these are well known "smart drugs" - and have a whole Research Paper (collaborative) justifying that use [13] - why should we seek alternatives?
...Well for one thing, these supplements can vary in Availability & Pricing. Some Nootropic (smart-drug) stores simply stop selling Adrafanil & Modafanil, without much notice. Sometimes due to Legal Concerns, especially if they are selling pure Pharma-Grade Modafanil.
Other Reasons: Not everyone responds well to these Drugs/Supplements, some get Hypersensitivity Reactions [14] Allergic Reactions [15], Anxiety [16] [17], Nausea/Vomiting [18]. NYMag also reiterated these possibilities for atypical reactions and gave personal account of such Modern-Day "Wall Street" of the Drug. Me for example, I HATE Adrafanil because playing with the dose (300-1200 MG) is more complicated then simply taking the straight Modafanil tablets or splitting them.
--> I also find Adrafanil & Modafanil to cause Anxiety, sometimes worsening OCD, although by means of its Alerting effects gets me "out of my head" and onto my surroundings; including Work... so when my Mind finds a Task, you could argue that Modafanil improves my OCD. However, Modafanil use without an outlet; either Writing or Day-Labor work = likely more OCD.
Adderall on the other hand, not so much. 98% of the time it COMPLETELY eliminates my OCD "Intrusive Thoughts" and in the process reduces my overall Anxiety level, by again, more prounouncedly getting me out of my head.
--> Be careful using Modafanil along with too much Coffee/Caffeine, it could lead to Insomnia (being unable to sleep) and Fast Heart Rate (tachycardia)....
--> On a bad day, Modafanil made it more miserable to be alone, but also made me more Social, and Fearless & Assertive, in some ways. I was more witty in conversation and better on my toes during Hard Tree Work.
--> It helped me Multi-Task.
5 ADRAFANIL/MODAFANIL ALTERNATIVES [2019]
1.) Syrian Rue: Syrian Rue (Penganum Harmala) activates Histamine neurons as its natural component; Harmaline, stops Histamine from leaving the Brain or being broken down too fast [19]!
Syrian Rue also can alleviate Depression / Sleepiness, by acting similarly to MAO-A inhibitor AntiDepressants; its constituents block MAO-A activity in the Brain [20]; leaving more neurotransmitters around for usage & uptake (assimilation).
2.) Life Extension Dopa-Mind: This product is tablets containing a special Wild Green Oat Extract (WGOE) patented as "NeuraVena". In clinical studies, it improves many aspects of Alertness & Cognition/Memory.
It works by blocking MAO-B (thus stopping Dopamine and PEA from being removed) [21] [22] [23] and inhibiting (blocking) PDE-4 - which leads to increased cAMP and prolongation of cyclic AMP's positive effects on Brain Function [24].
3.) Onnit Alpha Brain: This is a popular, highly reviewed Nootropic supplement - which is loved by almost everyone who takes it. It seems to have both immediate effects [25] and general long-term Alertness & ProCognitive effects [26].
It is studied to improve Recent Verbal Memory & Executive Function [27].
It has powerful cholinergic ingredients like Alpha-GPC, Huperzine A & Bacopa - all of which substantially improve Brain Function.
4.) "Genius Consciousness" Super Nootropic: Contains a plethora of excellently studied ingredients. Is known to hit FAST and deliver powerful long-term results [28].
It increases Brain Growth Cell Growth & regeneration (neurogenesis) [29].
5.) QUANTUMind: A little more expensive, but worth the price due to expensive ingredients that quickly stimulate Alertness and Concentration/Focus.
---> QUANTUMind Independent Review
2.) Life Extension Dopa-Mind: This product is tablets containing a special Wild Green Oat Extract (WGOE) patented as "NeuraVena". In clinical studies, it improves many aspects of Alertness & Cognition/Memory.
It works by blocking MAO-B (thus stopping Dopamine and PEA from being removed) [21] [22] [23] and inhibiting (blocking) PDE-4 - which leads to increased cAMP and prolongation of cyclic AMP's positive effects on Brain Function [24].
3.) Onnit Alpha Brain: This is a popular, highly reviewed Nootropic supplement - which is loved by almost everyone who takes it. It seems to have both immediate effects [25] and general long-term Alertness & ProCognitive effects [26].
It is studied to improve Recent Verbal Memory & Executive Function [27].
It has powerful cholinergic ingredients like Alpha-GPC, Huperzine A & Bacopa - all of which substantially improve Brain Function.
4.) "Genius Consciousness" Super Nootropic: Contains a plethora of excellently studied ingredients. Is known to hit FAST and deliver powerful long-term results [28].
It increases Brain Growth Cell Growth & regeneration (neurogenesis) [29].
5.) QUANTUMind: A little more expensive, but worth the price due to expensive ingredients that quickly stimulate Alertness and Concentration/Focus.
It is well-reviewed.
OTHER RESOURCES: Smart drugs: implications for general practice
Paul J Nicholson and Nigel Wilson, Chair
--> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325623/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654794/
In/Tags: natural modafanil alternatives 2019, natural adrafanil alternatives 2019, discount links for modafanil 2019, keep the brain awake longer naturally 2019, stop histamine from leaving the brain 2019.
200mg Caffeine + 800mg Adrafinil - how effective for day-labor 9 - 5? They both have histaminic properties. The motivation theoretically for the whole day? Any idea if adrafinil/modafinil has vasoconstriction/vasodilation properties?
ReplyDeleteday-labor being construction, while also having lots of other mental tasks for daily routine after work
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