How to Reverse Wellbutrin/Bupropion Induced Sexual Dysfunction/Side-Effects (Memory Issues as Well)

Many people have written about how to counter SSRI side-effects (including myself), however, to Date - no one has written about Wellbutrin related sides. Mainly because the 'side-effects' are both under reported and *unlikely*, that doesn't mean they don't happen.

Wellbutrin is classified as a Dopamine-Norepinephrine-Reuptake inhibitor, however, it has several other effects ; including ....

• Nicotinic Acetylcholine Receptor Antagonism (1) (*)
• Inhibition of Glutamate Release (2)
• Inhibition of Nitric Oxide in Brain (3).

(*) Wellbutrin is often classified as 'anticholinergic' because of the above effect; however, this is not accurate. It doesn't affect ALL Acetylcholine Receptors; just the nicotinic ones (associated with smoking).

Because of the above intermingling with other neurotransmitter systems - a distortion is often seen in human male sexual functions, the most common being.

• Increased libido but decreased arousal / erection capacity.
• An increase in sexual aggression but decrease in potency and classical libido.

This is mostly because Wellbutrin inappropriately shifts the balance between NORAdrenaline and Dopamine systems. The noradrenaline/norepinephrine becomes excessive causing the associated psychological side-effects.

Additionally, glutamate and nitric oxide are positively associated with the physiological/physical aspects of sexual arousal - that means they are both needed for erections (4) (5).

It is also plainly seen in <this study> that some of those effects of Bupropion are reversed by Sildenafil (Viagra) as well as L-Arginine. This reinforces that the nitric oxide system must be augmented to reverse sexual side-effects from Wellbutrin.

Finally, the most recent research in Erectile Dysfunction proves that Arginine-Glutamate and Yohimbine is an adequate combination treatment for both healthy individuals (6) and those experiencing anti-depressant related side-effects (7).

In my research though, both with those in the patient observation studies of UKI and based on the Public Internet Reports related to our studies - as well as in general forum reports....

I have found the most comprehensive approach to treating Wellbutrin-Induced Erectile Difficulties to be the trio-cocktail of .

• Viagra or Cialis ; which can be purchased =!HERE!=.
• + Arginine GLUTAMATE  {See Here}
• ++ YOH (Yohimbine) but only if no previous diagnosis of Anxiety (G.A.D, 300.OO <(Sv.Anxiety)> etc)

(**I've also found the above cocktail to alleviate Memory Issues resultant from Wellbutrin-Use**)

           **MAIN CITATIONS / REFERENCES**

Physiology of penile erection

A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor

Bupropion is a nicotinic antagonist.

Inhibition of glutamate release by bupropion in  cerebral cortex nerve terminals.

Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of bupropion, a dopamine reuptake inhibitor.

Central control of penile erection: a re-visitation of the role of oxytocin and its interaction with dopamine and glutamic acid.

Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction.

Pharmacogenetics of glutamate system genes and anti-depressant-associated sexual dysfunction.

~ SUPPORTING CITATIONS / REFERENCES ~

Recent advances in the treatment of neurogenic erectile dysfunction.

Pharmacologic Treatment of Erectile Dysfunction

Erectile dysfunction: from biochemical pharmacology to advances in medical therapy.

A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction.

~! OTHER MISCELLANEOUS REFERENCES !~

BODYBUILDING.com - Supplementing Your Sex Life!