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- The most common cause, biologically, is excessive Serotonin (5-HT) activity. It can be caused by supplementing 5-HTP or simply intaking too much tryptophan in the diet with your antipsychotic drug and / or because of use of an SSRI-antidepressant with the neuroleptic-medication. The problem comes from the 5-HT2A Receptor/s. (1) (2) (3)
- Too much blockade at post-synaptic Dopamine D(2)L Receptors leads to akathisia as well as dyskinesia (4) (5) (6).
- GABA-Receptor Deficiency and / or GABA deficiency may lead to Predisposition.... this is also evidenced in Benzodiazepine and / or Gabapentin treatment of ExtraPyramidal (EPS) side-effects from neuroleptics and SSRI's as well as other Psych-meds. (7) (8) (9) (10)..
- Low Plasma (Blood) Iron (mineral) levels and thus, Iron-deficiency leads to akathisia and the most common predisposition/contributing factor to akathisia's. (11) (12) (13) (14)
- Vitamin B6 at high doses has been found to alleviate akathisias since it modulates dopaminergic/serotonergic neurotransmission; favoring dopaminergic neurotransmission.{the best brand of B6 for antipsychotic/neuroleptic akathisia is Solgar, because it is HPLC-Verified (tested independently and analyzed by a lab}.
***OTHER NOTES***
- Fluvoxamine (Luvox) is one of the Only SSRI-medications that DON'T cause akathisias - and that is because it activates sigma-1 receptors which leads an overall enhancement of GABA release as well as other favorable neurotransmitter changes.
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ReplyDeletePoint 3 seems false and based on the shallow similarity of "calming" that is attempted to be achieved. But I can testify, and clearly it is even easy to imagine, that the automatic physical movement of akathisia is not necessarily identical to, or can be reduced to, a lack of calm or even "tiredness" in the mind. These are completely independent circuits, or at least not so directly depend. Any confirmation about the usefulness in that way - which obviously is hardly seen as a real solution, even temporary - must be seen as due to the shallowness and condescension that patients and their serious side-effects are traditionally treated with in those fields. The difference is also clear, for example, in beta-blockers vs and gaba-ergic action, or any generically "calming" remedy vs a specific one. (See how easy and obvious it becomes all of a sudden when you are not conventionally allowed to treat the patient as a nazi-experiment.)
ReplyDeleteOn the other hand, it must be supposed that "akathisia" is often used shallowly or in different meanings.
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