Don't worry, you're not the Only one dissatisfied with questionable answers from randoms on Yahoo Answers or other weird contributors (not that Yahoo is weird, but some of people on there Are ).
I've already explained the concepts of "Disruption" & "Dysregulation" in regards to neurotransmitter frustration and biological pathways - now I will explain 'turnover' , a term commonly used to depict scenarios where a drug or substance (natural or synthetic) affects the function of a given neurotransmitter in the Brain .
A quick explanation for newbie's....
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The accurate (easy) definition for neurotransmitter turnover is the ''amount of a neuron or cell moving in or out of a fixed pool at steady state per unit time'' - however, for your average Joe or people who don't understand or feel like decoding lingo, it simply means : the amount of a neurotransmitter that is in continuous function within a specific (described, studied) brain region and / or organ region. {Even Simpler Explanations and Examples Given Below Next 2 Paragraphs}
Yes, there are neurotransmitters in your Gut, Folks!
Neurotransmitter turnover equates to the accumulation of a neurotransmitter in a brain region or synaptic space as well as the removal , because turnover is estimating the ''rate'' of the process based on the transportation of that neuron/neurotransmitter. So essentially, enhancement of turnover is increased movement and activity / accumulation of that neurotransmitter which of course, at some point has to be removed because that is the normal process of a neurotransmitter (to be reabsorbed; entered into reuptake) - enhancement of turnover LEADS TO (Indirectly) an increased probability of another substance being able to manipulate that system's ACTUAL FIRING / RELEASE Rates...
So, TURNOVER basically means the amount specifically being incorporated (transported, uptaken) into the region and it often describes the life cycle of a neuron or is placed in the same context. Turnover is not the same thing as 'neurotransmitter release' but it often precedes it - there has to be enough neurotransmitter available in order for them to be 'released'. Turnover plays a role in that ''availability''. It is a prerequisite in many cases, and thus, is mentioned in many psychopharmacological studies and major Tests from Universities.
! EVEN SIMPLER EXPLANATION - EXAMPLES !
- Serotonin , histamine, dopamine turnover = the amount of a neurotransmitter continuing it's life processis and moving (being transported) into an active brain region to do it's work.
- "Enhancement'' of turnover is an amplification of the neurons integrity and continuance (moving along, doing it's job) and thus, leads to of course, more neurotransmitter activity in that System (serotonin, histamine, dopamine , glutamate etc)
**MAJOR CITATIONS/REFERENCES**
University of Washington [Faculty] ~ Neurotransmitter Explanation/s
Turnover of Neurotransmitters in the Brain: An Introduction
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Neurotransmitter "Firing" Will be Described Next in Our Next Article.
From what I know high serotonin or dopamine turnover is not good in most cases. Movement disorders like Parkinson's or dyskinesia have higher monoamine turnovers. But I've met some info that in Tourette's disorder 5-hiaa is low... The opposite of a panic disorder for example.
ReplyDeleteSerotonin levels are higher in Panic Disorder as well as pretty much every Anxiety disorder around that has been demonstrated in Psychology. Turnover is a fairly accurate method of determining the amount of neurotransmitter or metabolites available however, it can be difficult to measure it in terms of behavior since other metabolites have to be taken into account.
DeleteStress can affect turnover as well as synthesis of a neurotransmitter.
Thanks for the input.
How do they measure serotonin turnover??
ReplyDeleteSo if one has low 5-HIAA on urinary test, does it mean your turnover is too high?
ReplyDelete