Does Masteron (DHT, Drostanolone Propionate) Lower / Decrease Cortisol Levels?

:::Q:::

"Area, does Masteron have an effect on Cortisol? Does it decrease cortisol levels?"

~Dave Q

:::A:::

Research shows that Dihydrotestosterone inhibits the HPTA stress response by cross-activating estrogen-Receptor beta, this causes a decrease in circulating corticosteroids, strong compounds, like Masteron, tend to have direct blocking action on Cortisol, by acting both at the hypothalamus and by acting on beta-endorphin related pathways [!].

So Yes, Masteron absolutely can lower Cortisol levels. 

Perhaps not as much as more ''official'' cortisol blockers, but it does to an extent.

***SOURCES***

Horm Behav. Author manuscript; available in PMC 2013 Jan 1.

Published in final edited form as:

Horm Behav. 2012 Jan; 61(1): 147–155.

Published online 2011 Oct 1. doi:  10.1016/j.yhbeh.2011.09.010

PMCID: PMC3264812

NIHMSID: NIHMS334274

TESTOSTERONE AND SPORT: CURRENT PERSPECTIVES

 Drostanolone Propionate : Chemical Database and Readout by PubChem @NIH - National Institutes of Health 

J Neurosci. 2006 Feb 1;26(5):1448-56.

The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus.