Long Term Changes Caused by Cocaine Use

Cocaine has many long term effects, but despite its power, not all changes are “good”. For example, it DOES downregulate presynaptic dopamine receptors “autoreceptors” leading to more dopamine, but 3+ months of use also increases dopamine transporters leading to DECREASED total dopamine availability. (https://pubmed.ncbi.nlm.nih.gov/11820798/)

STUDY on D2 Function & Cocaine: https://pmc.ncbi.nlm.nih.gov/articles/PMC8072657/

STUDY on D2-Alteration & Cocaine Use: https://pubmed.ncbi.nlm.nih.gov/23637801/

STUDY 2 on D2 Function & Cocaine: https://pubmed.ncbi.nlm.nih.gov/23884939/

FACT VS FICTION

FACT: Cocaine DOESN’T damage brain cells in everyone, in fact, it simply shifts one’s thinking to more “one-track” and “dissociated” aka Crude or Linear thinking. STUDY: https://pmc.ncbi.nlm.nih.gov/articles/PMC8571051/

For many people it is the “up-and-down” cycle of getting high that leads to the shift in thinking, the “crash” or sustained effects vary per person, but generally for most people damage to the receptors is inevitable with cocaine use; but much of it is psychological, the stress from the “dependency” or “wanting” to get High explains the psychological phenomenon of “loss of brain cells”.

There is no clear study showing it’s NOT psychological, but it is clear that cocaine DEFINITELY overstimulates dopamine receptors at an alarming rate.

“Coke” is a drug that also is unique in that it raises norepinephrine more acutely and intensely than Adderall or Methamphetamine, that’s why many users get paranoid while smoking it.

If you are looking for a stimulant that is “functional” though METH is definitely better.

However these drugs are controlled substances, Adderall is a safe alternative and can be bought on

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Benefits of Adderall

—> Reversal of Ataxia/Loss of Dexterity

—> Laser Sharp Focus

—> Good Usage of Common Sense

—> Improved Creativity

—> Complete Reversal of Daytime Sleepiness

The “Magic” of Cocaine

———————————

Despite it having some “up-and-down” effects, cocaine has willpower magnifying properties that exceed any substance - acutely, except when METHAMPHETAMINE and specific genetics/ancestries are combined. For the most part though, cocaine is the most dramatic, willpower maximizing substance and most euphoric substance, hands-down.

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ONNIT Alpha Brain Review

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So I’ve taken Alpha Brain about 8 times so far, sometimes I have it instacarted from Wegmans, sometimes I buy in-store at Rite Aid and CVS, each time I notice a pronounced anti-anxiety effect & focus effect, it notably takes away obsessive-compulsive symptoms but at the same time is not like a jolt like Adderall or Nicotine.

It does compliment those substances, though.

Especially seems to go well with Caffeine & Yohimbine. I think the Cat’s Claws MAO-B inhibition is what gives Alpha Brain its mood boosting effect. However, the Bacopa probably plays a role due to its serotonergic effects (TPH2) boosting.

—> I notice benefits from the first day. It benefits quickness of recall and reaction time mainly.

—> It reduces OCD symptoms.

—> Reduces Anxiety/GAD symptoms. (“Does Alpha Brain reduce GAD symptoms?”)

—> It increases muscle strength and seems to make veins poke out more. (Probably due to Acetylcholine induced vasodilation/vasodilatation).

—> It seems to be very relaxing in general but yet alerting at the same time.

My take is that the “Alpha” part of the name of the supplement definitely is accurate, it increases…

—> Assertiveness

—> Quick Recall/Quick Wittedness

—> It keeps you awake.