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Sunday, July 5, 2015

Why Am I HyperSensitive/SuperSensitive to Stimulants? (Answers to Question Here) (Biological Cues And Molecular Paradigms) (Sensitivity to Uppers)

This article aims to be the sensitivity depiction equivalent to contributing factors in stimulant dependence - in this article, I will go over the biological and psychological reasons for super-sensitivity or over-sensitivity to stimulants. The reasons for over-sensitivity to stimulants are usually a combination of genetic factors and psychosocial factors which play a role in self-perception of the super-sensitivity self-diagnosis. 

Don't get me wrong, it exists entirely on a biological level as well...

One of the most common reasons for stimulant super-sensitivity for average joe's who may have not had a prior incidence of this problem or in those who unexplainably develop super-sensitivity - is the unawareness of other medications precipitating the issue.

So before you get to the genetic or nutritional or psychosomatic factors, first consider these.


  • Are you taking ST.JOHN'S WORT supplements or any herbal preparations with reuptake or MAO-inhibiting properties? These can most certainly alter how you respond to even ordinary stimulants(1)(2).
  • Another common one is the use of benadryl, believe it or not, benadryl's dual SSRI properties and anti-muscarinic properties most of all, make it a more 'casual' candidate for amplifying the effects of stimulants the day after it puts you to sleep (or doesn't)(3)(4)(5).
  • Sulpride derivatives or particularly amisulpride; these may increase the effects of stimulants as they block the D2R autoreceptors which causes more dopamine to be released(6)(7)(8).
  • Anti-psychotic drugs of other types may also amplify effects of stimulants , particularly the antipsychotic medications that have a strong anticholinergic or strong ratio of D2S to D2L favorability(9)(10)(11)
  • Some anti-depressant drugs notably those acting on NET but not predefined as being stimulants such as imipramine, amitryptiline, Venlafaxine and even the newer anti-depressants such as brintellix/Vortioxetine can alter stimulant sensitivity significantly(12)(13).
  • Opiate antagonist drugs such as naloxone or natrindole may increase sensitivity to stimulants; particularly those that release glutamate or noradrenalin directly(14)(15)


Some gene disruptions are known to affect stimulant sensitivity as well as motivation to seek stimulants and general craving occurrence, notably, The D2S knockout mice were pretty impressive poster rodents so I s'pose if you have been born with less dopamine D2S receptors you would have a higher degree of stimulant sensitivity (17) and an increased preference for stimulants(18); whereas higher dopamine D2s activity would be associated with less sensitivity to stimulants and possibly less seeking of certain forms of stimulants. 


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