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Tuesday, July 12, 2016

Natural Kappa (K/KOR) Opioid Receptor Antagonists (Herbal Opiate/Opioid Antagonists) (Includes Where to Buy Them)


Kappa-opioid Receptors are incredibly important in terms of Dopamine-release, but as an anti-target, or anti-factor; a negative modulator of Dopamine release/activity[1] [2] [3]. Because of that research, the search is on to find natural/herbal Kappa opioid blockers/antagonists.

That search has yielded the following results.


  1. Amentoflavone [4] [5] (the most easily purchasable natural kappa antagonist). {Buy it HERE}
  2. Pawhuskin A [6] [7] - Isolated from the "Purple Prairie Clover" AKA Dalea purpurea. As of this point I have no source for it. Contact me @area1255x@gmail.com if you have a source you'd like to add.
  3. Noribogaine. Although it occurs naturally in the Iboga plant, it is more frequently used separately to research and experiment with Addiction models. It is not a suitable substance for practical use, because it has many other properties and is nearly an impossible task to obtain on its own and the whole Iboga plant / shrub can not be consumed without giving way to its other unwanted effects. It's listed here for factual / research purposes only[8] [9].
  4. Ginkgo Biloba Extract; Ginkgo is an easily obtainable extract {Buy HERE} which has been and still is being used for memory/cognition issues [10] [11] as well as to enhance libido [12] [13] - it functions as a dopamine-promoter [14] and kappa-opioid antagonist [15] but also promotes histamine activity in the brain as well [16]; which may cause Insomnia [17].
  5. Instant Coffee: Coffee, yup that's it. Drinking Coffee will antagonize opioid receptors [18] [19] [20] [21] - although the effect is more related to MU/M/MOR than Kappa/KOR/K.



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