Area-1255 ~Logo~

Thursday, January 8, 2015

A List of Available Serotonin 5-HT4 Receptor Antagonists - Where to get 5-HT4 Blockers

In my quest to find serotonin ligands, particularly, antagonists/blockers of the 5-HT(4) receptor - I have come across a few natural antagonists, with varying potency - and one chemical not available yet but still in clinical testing.


I will be updating this article as I find more.


The first natural 5-HT(4) antagonist would appear to be chamomile extract.
Though the study cited showed it was particularly an ethanol extract, and it was included in a formula, however, by binding assays and other chemical tests - it was revealed the chamomile component was indeed the binder of the 5-HT4 receptor  - which probably accounts for at least part, of the anti-diarrhea/Irritable Bowel treatment; STW 5.

Additionally, chamomile has anti-anxiety effects which probably relate to it's serotonin 5-HT(4) receptor blockade.




~CLICK ON THE IMAGE TO GO TO THE STUDY OR CLICK THE LINK ABOVE~




My favorite CHAMOMILE PRODUCT - is the one below.



                                                                       




THE SECOND NATURAL 5-HT4 ANTAGONIST WOULD BE THE AMINO ACID L-LYSINE!!!

                      http://www.ncbi.nlm.nih.gov/pubmed/14676321

                                                                         

Mianserin; A Novel Anti-Depressant ;Mechanism of Action and Binding Affinities

....




Wednesday, January 7, 2015

The Plagues of Societal Disconnect Should be Beaten with Heart, The Solution to the Negativity that Abounds is Re-Synchronizing The Elements of the Older Days with the Vibrance and Energy of the Current Days




People often go about life in a general disconnect, achieving some ends of pleasure, enjoying some moments and then in other times, being in utter sadness, grief or disappointment. Yet, in many instances of negative reactions, or of dissolution of otherwise legitimate entities, it is directly preceded by and fueled by blame of another - or blame of anyone else in range - when indeed, in some instances no one should be blamed at all. 

Many people are always looking for someone to blame, they desire the easy way out - people lose track, they figure parts of others out - endlessly searching for approval of others. Yet, in all of this - our own productivity vanishes , we become short-sighted in our quest for the approval of others, and in many cases..not realizing that others would approve us better if we just found parts of ourselves, and acted like ourselves.



I wonder..if we all took our own direction, went for our dreams, without so much vanity, without so much unwarranted concern as to the thoughts of others - understanding we are all imperfect, how much more peace in this world would there be? 

Look, it may not be logical to you, but I'm someone who believes that the pungency and effectiveness as to how much we can change is directly dependent on how much we believe, if we doubt things can improve, they won't....odds don't matter. Righteousness does, even if it isn't the popular thing to do or be.

Maybe the answer is in my messages , but maybe it won't be picked up til later, that doesn't mean I would condemn or disconnect people for disagreeing, if I have confidence in what I say, then would it not make sense to let words stick? To let the simmer. To let them go on as a ancient vibe, in a dramatic and chaotic world.

IF YOU TRULY FIGHT FOR WHAT YOU BELIEVE IN , THEN WHY WASTE SO MUCH TIME EMPHASIZING IT UNTO THE AUDIENCE OF BUT A FEW?


Likewise, if you truly believe in your words, and you are honest, let them stand like a sword, because with time, that sword collects strength , and people look back on the spirited words.

Even if you are deemed wrong for a moment, and EVEN if you are wrong, that should not be taken personally - but only as a means to achieve more.

Why am I going  in to all of this ?

BECAUSE part of the reason for societal disconnect, envies and un-necessary feuds is the lack of standing, caring too much about such a little conflict, instead of bettering ourselves beyond measure....we often CREATE or worsen our own problems, in addition to destroying our own productivity, by engaging in a seemingly fruitful or measurable campaign against a rival - but unless the cause is so great that it overdoes and outweighs the cost that the battle would draw in (persuade) - then why risk everything to mean so little to just a few. 

Should their opinion mean THAT much, and even if it does, people reserve the right to think , and don't usually change when they are crushed by a vain or arrogant attempt - and certainly not when people try to 1-up them. Because you see, being proven right isn't always right, especially if it's just for our own gratification.

We need to find peace within ourselves before we can spread love as a whole, and let's not think love is weakness, for there is a brotherly love that has been forgotten - once upon a time, it gave us merit, and it yolked our struggles as one - there were hard times, but we didn't let these times, and minor conflicts get the best of us, we learned to forgive and forget, and this worked well for many notable characters in the past, both fictional and real - so why don't we take our honor back from the thieves?

TAKE A STAND FOR THE BETTER GOOD, AGAINST CORRUPTION, DENY THOSE WHO ABSTAIN FROM LOVE, PEACE, AND NOBILITY, DENY THOSE WHO SEEK AFTER DISRUPTION, ANARCHY, AND CHAOS. DENY THOSE WHO PERSISTENTLY DECEIVE..

But.... do what is best on proper judgement, for all deserve the chance to turn from darkness - and labels are widespread amongst us....give everyone a chance, but don't let one persons chance consume you either...be vigilant, but graceful, be aware, but wise, but strong...and of courage.

SO BACK TO THE TOPIC AT HAND; equal love both in the concept of relationships and about general societal disconnect and the relative lack of peace amongst people - well here's my genuine, spontaneous and outlining statement to conclude this message today.



Tuesday, January 6, 2015

Serotonin 5-HT 1 C Antagonists - 5-HT1C Receptor Antagonism contributes to Tricyclic and NaSSA Anti-Depressant Actions






































http://www.ncbi.nlm.nih.gov/pubmed/8420788
http://www.ncbi.nlm.nih.gov/pubmed/8078990

How to Upregulate NMDA Receptors and Boost Their Function (Also Discussing Positive Allosteric Modulators of NMDA)

NMDA (N-Methyl-D-Aspartate) Receptors are a type of glutamate receptor, they play a role in mobilizing calcium and activating calcium-channel and calmodulin-dependent biological  processes. They have several unique properties that differentiate them from other glutamate receptors, such as the metabatropic and KAINATE receptors (commonly referred to as the most toxic).

NMDA-receptors have a bad rap, they have been postulated to play a negative role in neuro-degenerative disorders, however, on the flip side - they have positive effects when activated moderately, or separately without excessive activation of other glutamate subtypes.

NMDA Hypo-Activity, is associated with obsessive-compulsive-disorder and schizophrenia, and may also play a role in the pathology / etiology of depression and sexual dysfunctions.

The benefits of NMDA agonism, upregulation and positive allosteric modulation are extensive, the process of activating these receptors, providing one is not in a HYPER-glutamatergic state, are going to baffle the human mind.

We're looking at.


  • Treatment of OCD; Obsessive-Compulsive-Disorder (!) (!)
  • Treatment of Schizophrenia, and psychotic symptoms induced by low glutamate levels(!) (!).
  • Regulating dopamine, and potentiating hypothalamic activity - helping to treat infertility, low libido and sexual dysfunctions in both men and women(!)  (!) (!)
  • Increased fear-learning and long-term consolidation of fear-memory, including fear extinction ; thus adapting to fears and learning to face them better, and more naturally (!) (!).
  • Decreased anxiety and incidences of depression in some individuals.
  • Less paranoia, and increased sociability due to increased oxytocin by the glutamate NMDA-channel opening and subsequent interactions between calcium channels and nitric oxide.
  • Increased vasodilation and workout performance, enhanced nitric oxide levels.(!) (!)
  • Alleviation of long-term memory issues and active memory disruption.(!) (!)
  • Restoration of ejaculation process in men(!).



That's quite a list, now I'm going to make it very simple and brief, here's a screen shot of how to upregulate and boost NMDA-receptor function.





 CLICK THE IMAGES TO GO TO THEIR RESPECTIVE BOOKS




One of the highest quality combination products, with both pregnenolone and DHEA, is a gel called "DERMACRINE". You can purchase it at the original "BPS" version, the alternative 'Iconic Formulations' (modern-day) version or you can buy AN ALTERNATIVE that RAISES DHEA + Pregnenolone PRODUCTION in the Body; called TEST-STACK PRODUCT 17; HORMONE BOOSTER FOR MEN & WOMEN. 

(There's also ANDROHARD which works in a Similar Manner)


-VIP DISCOUNT PAGE HERE-
[^ For Test Stack's "Premium" Testosterone & DHEA Booster for MEN & WOMEN]
SOURCES / REFERENCES SCREENSHOTTED




**GENERAL REFERENCES**

Involvement of the NMDA System in Learning and Memory




Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.


Activation of NMDA receptors in lumbar spinothalamic cells is required for ejaculation


Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex.


NMDA receptors and fear extinction: implications for cognitive behavioral therapy.


The role of NMDA receptors in the signal attenuation rat model of obsessive-compulsive disorder




TREATING NMDA RECEPTOR HYPOFUNCTION

NMDA receptor and schizophrenia: a brief history.

Long-Term Potentiation and Memory

Of all possible OCD treatments,


click here now

Saturday, January 3, 2015

DaMageZ's RS Transaderm REVIEW & Log (NON-SPONSORED, INDEPENDENT) - Is it worth the money?



Hey fellas, DaMage is here again, this time to review / log a product known as "RS Transaderm" - it's a transdermal DHEA/Pregnenolone formula with an anti-estrogen complex that can boost testosterone levels....so , is RS Transaderm any good?

Well I'll give you a no-bullshit review, the gel is not perfect, but pretty close to it.


I WAS USING IT AS PART OF A REGIMEN TO BOOST TEST LEVELS AND STRENGTH / PERFORMANCE
THE ONLY OTHER PRODUCTS I WAS TAKING AS PART OF THE REGIMEN WERE CAFFEINE AND CREATINE, WHICH I HAD ALREADY BEEN TAKING MANY MONTHS BEFORE..... CLEAN LOG FELLAS, CLEAN LOG ! 



In the first week of using it, I noticed some stuff towards the end of the week mainly. I did notice a mild increase in focus and libido the first few days, but it seemed to dissipate thereafter for a couple days. Until the 6th and 7th day.
My observation is that on these days,  I noticed a type of diuretic effect, probably due to the estrogen decreases.

I took blood work on the second week, and a confirmed estrogen decrease from 25 pg/mL to 16 pg/mL and a consequential increase in testosterone from 899 ng/dl to 948 ng/dl was noted, should be noted each test was custom and from a different lab because I don't have insurance.

Libido was way up on the second week , half way through , this is when everything became noticeable, and every ass fuckable. ;)

In addition, I became much more vascular on the second week.

On the third week , I started making noticeable gains, both in strength and mass in the gym, and shed serious body fat off of my abs, much quicker than usual - as I've had issues with  that area.


The fourth week I continued making gains, about 2lbs , and it's worth noting I only ate 2300 calories / day. Only 80 g of protein , which is remarkable, and shows the hormonal legitimacy of this product.

BENCH PRESS SENSATIONS;PUMPS WERE AMAZING , AND CONTUINING TO GET BETTER! This is MUCH better than a "nitric oxide" product!



TOWARDS week 7 , I gained even more mass and my biceps started growing new veins, and getting much more solid , even though this was to an extent before, the veins were new and more pronounced here.

Libido is still maintaining it's surge all the way through.

I also noticed a great appetite increase , for w/e reason this has happened all the way through, but more notable starting on the 7th week here.

General energy levels are through the roof, and it's almost comparable to masteron in some regards.



CONCLUSIONS
  • MASS GAINS FOR SURE, EVEN WHILE ON A LOW-MODERATE PROTEIN DIET.
  • STRENGTH GAINS AND REP CAPACITY INCREASED ON BENCH
  • STRONG, PERSISTENT LIBIDO SURGE, NOT EQUIVALENT TO OTHER TEST BOOSTERS, WAY MORE PRONOUNCED. WANTED TO BANG EVERYTHING IN SIGHT.
  • STRONG SENSE OF FOCUS
  • INCREASED APPETITE IS MORE PRONOUNCED 6-7 WEEKS IN
  • VASCULARITY INCREASED GREATLY, AND AB FAT FINALLY MELTED OFF!
  • JUST A GENERAL MASTERON-LIKE FEELING
  • EXCELLENT PUMPS; Scratch beet root and all that jazz! THIS IS BETTER THAN WHAT YOU WOULD GET ON A NITRIC OXIDE; N.O PRODUCT OF ANY KIND!
You can buy transdermal DHEA supplements, but RS Transaderm is the best out of all transdermal supplements .

It can be bought at ruthless supplements - CLICK HERE TO GO THERE.


OTHER TAGS ; WHERE TO BUY TRANSDERMAL DHEA / PREGNENOLONE ONLINE 

Friday, January 2, 2015

Where to buy Pure, Pharmaceutical/Research Chemical - Histamine H3 Antagonists Online

DISCLAIMER;LEGAL
These products / chemicals are legal and not regulated by any law, thus they are are safe to buy online, however customs may have their own discretion regardless of legality.



People have been increasingly interested in these H3 antagonist compounds, and with good reason.

They have promise in treating..

  •  Attention Deficit Hyperactivity Disorder (ADHD) (!) (!)
  • Somnolence and other Vigilance disorders (!) (!)
  • Some symptoms of schizophrenia may be improved on them.. (!)
  • Dementia and other cognitive disorders..and that's just a start. (!) (!)


They may also possess pain relieving and fat burning effects.

The problem is the sources for them are relatively obscure, but here I will list some common ones and where to get them.


KEEP IN MIND I WOULD NEVER LINK YOU TO A SITE I HAVE NOT TRIED MYSELF, AND THESE COMPOUNDS ARE NOT REGULATED...NO LEGALITY ISSUES HERE FELLAS!

BETA HISTINE (BETASERC,SERC) - A histamine H3 antagonist that can reduce the expression of histamine H3R's over time, and can treat meniere's disease symptoms such as tinnitus, vertigo and hearing loss....it can also promote cognition and has a stimulant effect...




  • May cause itching as a side-effect and other histamine related issues...use with caution or avoid if you have asthma.


Can be bought at international drug mart or you can e-mail betahistineusa@gmail.com for a domestic source within the USA.

Tags : DOMESTIC SOURCE BUY BETAHISTINE IN USA.



PITOLISANT - A POTENT HISTAMINE H3 ANTAGONIST IN PHASE III CLINICAL TRIALS. Stronger than beta histine in regards to wakefulness and stimulant properties as well as nootropic properties.....

Can be bought at "TRANSHUMAN TECHNOLOGIES".


Click HERE to go to transhuman technologies website for ordering real pitolisant online.



**OTHER RESOURCES**



click here now

Organic Kratom #1 Shop!