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Tuesday, January 6, 2015

How to Upregulate NMDA Receptors and Boost Their Function (Also Discussing Positive Allosteric Modulators of NMDA)

NMDA (N-Methyl-D-Aspartate) Receptors are a type of glutamate receptor, they play a role in mobilizing calcium and activating calcium-channel and calmodulin-dependent biological  processes. They have several unique properties that differentiate them from other glutamate receptors, such as the metabatropic and KAINATE receptors (commonly referred to as the most toxic).

NMDA-receptors have a bad rap, they have been postulated to play a negative role in neuro-degenerative disorders, however, on the flip side - they have positive effects when activated moderately, or separately without excessive activation of other glutamate subtypes.

NMDA Hypo-Activity, is associated with obsessive-compulsive-disorder and schizophrenia, and may also play a role in the pathology / etiology of depression and sexual dysfunctions.

The benefits of NMDA agonism, upregulation and positive allosteric modulation are extensive, the process of activating these receptors, providing one is not in a HYPER-glutamatergic state, are going to baffle the human mind.

We're looking at.

  • Treatment of OCD; Obsessive-Compulsive-Disorder (!) (!)
  • Treatment of Schizophrenia, and psychotic symptoms induced by low glutamate levels(!) (!).
  • Regulating dopamine, and potentiating hypothalamic activity - helping to treat infertility, low libido and sexual dysfunctions in both men and women(!)  (!) (!)
  • Increased fear-learning and long-term consolidation of fear-memory, including fear extinction ; thus adapting to fears and learning to face them better, and more naturally (!) (!).
  • Decreased anxiety and incidences of depression in some individuals.
  • Less paranoia, and increased sociability due to increased oxytocin by the glutamate NMDA-channel opening and subsequent interactions between calcium channels and nitric oxide.
  • Increased vasodilation and workout performance, enhanced nitric oxide levels.(!) (!)
  • Alleviation of long-term memory issues and active memory disruption.(!) (!)
  • Restoration of ejaculation process in men(!).

That's quite a list, now I'm going to make it very simple and brief, here's a screen shot of how to upregulate and boost NMDA-receptor function.


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Involvement of the NMDA System in Learning and Memory

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

Activation of NMDA receptors in lumbar spinothalamic cells is required for ejaculation

Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex.

NMDA receptors and fear extinction: implications for cognitive behavioral therapy.

The role of NMDA receptors in the signal attenuation rat model of obsessive-compulsive disorder


NMDA receptor and schizophrenia: a brief history.

Long-Term Potentiation and Memory

Of all possible OCD treatments,

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1 comment:

  1. Basically a more long-term solution for boosting memory and mood fellas, thanks for this Jay!


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