Tuesday, January 6, 2015

How to Upregulate NMDA Receptors and Boost Their Function (Also Discussing Positive Allosteric Modulators of NMDA)

NMDA (N-Methyl-D-Aspartate) Receptors are a type of glutamate receptor, they play a role in mobilizing calcium and activating calcium-channel and calmodulin-dependent biological processes. They have several unique properties that differentiate them from other glutamate receptors, such as the metabatropic and KAINATE receptors (commonly referred to as the most toxic).

NMDA-receptors have a bad rap, they have been postulated to play a negative role in neuro-degenerative disorders, however, on the flip side - they have positive effects when activated moderately, or separately without excessive activation of other glutamate subtypes.

NMDA Hypo-Activity, is associated with obsessive-compulsive-disorder and schizophrenia, and may also play a role in the pathology / etiology of depression and sexual dysfunctions.

The benefits of NMDA agonism, upregulation and positive allosteric modulation are extensive, the process of activating these receptors, providing one is not in a HYPER-glutamatergic state, are going to baffle the human mind.

We're looking at.

Treatment of OCD; Obsessive-Compulsive-Disorder (!) (!)
Treatment of Schizophrenia, and psychotic symptoms induced by low glutamate levels(!) (!).
Regulating dopamine, and potentiating hypothalamic activity - helping to treat infertility, low libido and sexual dysfunctions in both men and women(!) (!) (!).
Increased fear-learning and long-term consolidation of fear-memory, including fear extinction ; thus adapting to fears and learning to face them better, and more naturally (!) (!).
Decreased anxiety and incidences of depression in some individuals.
Less paranoia, and increased sociability due to increased oxytocin by the glutamate NMDA-channel opening and subsequent interactions between calcium channels and nitric oxide.
Increased vasodilation and workout performance, enhanced nitric oxide levels.(!) (!)
Alleviation of long-term memory issues and active memory disruption.(!) (!)
Restoration of ejaculation process in men(!).

That's quite a list, now I'm going to make it very simple and brief, here's a screen shot of how to upregulate and boost NMDA-receptor function.

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SOURCES / REFERENCES SCREENSHOTTED