Natural / Herbal Serotonin 5-HT(7) Receptor Antagonists/Blockers {Potent NATURAL Serotonin Blockers}

"Serotonin 5-HT7-receptor blockers/antagonists may be one of the most ideal serotonergic modulating candidates with a distinct ability to decrease anxiety, and depressive symptoms, naturally(!)!"

There's one major plant compound/herb that can actually antagonize or block the 5-HT7 serotonin receptor, this would result in naturally lowering cyclic AMP and cortisol levels...

The herb is none other than the well-known SKULLCAP, infamous for reducing anxiety stronger than most other herbs!  It's high efficacy and consistent results across a broad variability of patients with different backgrounds, shows that serotonin modulation is ideal for anxiety and depressive disorders...however, there's not many compounds available that can block specifically the 5-ht7 receptor without affecting others. 

My recommended skullcap extract is below.

                                                                       

What are some Natural Serotonin Reuptake Inhibitor's ? ("True" Natural SSRI's)

While I can appreciate some of the well-put articles on livestrong.com and other similar blogging sites , I have to disagree with misinformation and inaccurate subtitles.

A lot of times people see an herb involved in a small study / sample, and immediately skim through the sentences and context of the study to see "boosts serotonin" - but this does not necessarily equate to being a "natural serotonin reuptake inhibitor"(1).

You see, inhibiting serotonin reuptake is the same as saying "INHIBIT THE SEROTONIN TRANSPORTER" or inhibit "SERT" ; which stands for serotonin transporter(2).

Thus, a REAL, "true" natural SSRI would be something proven to inhibit SERT with an affinity (and efficacy) for *human* SERT proteins.

Here's one, it's called KANNA ROOT or it's plant name ; Sceletium tortuosum.
    {click image to go to study and get better view}

As a natural SSRI though, many times kanna is over-marketed and as such - poor quality extracts are found abroad ----- the product below , "GABATrol" has helped me in more than a couple ways, and I find it to be a crude, powerful extract of kanna which did actually elevate serotonin in blood work. 

So unlike other similar products, it seems to be a trustable patented "gem"...even though kanna is not the only ingredient in the formula, it's the only ingredient in it that raises serotonin by any appreciable concentration....

                                                                 \

The second, and much more complicated natural SSRI - is called  ST.JOHN'S Wort; the reason its complicated, and even a bit sketchy - is because the serotonin uptake inhibiting properties depend on the HYPERFORIN content and amount, which varies from batch to batch and product to product...so you'd want a  HYPERFORIN standardized extract or even more preferably, pure hyperforin , which is listed below.

It's an expensive "pharmaceutical grade", over the counter anti-depressant with additional immunity boosting and anti-bacterial effects , one of the few over the counter supplements that can run very close to a "panacea".

Though it's not cheap, at least you know you are getting serotonin reuptake inhibiting component and not at varying undefined amounts as with herbal extracts.

                                                                        

The study is also posted below.

Amisulpride : A forgotten "Old-School" AntiPsychotic with A Superior Anti-Depressant Profile & Unique Mechanism of Action (Little to no side-effects)

Amisulpride certainly doesn't carry the wide array of pharmacological actions that most "familiar" or "Atypical Antipsychotics" do, but that doesn't make it any less potent(1). 

        

AMISULPRIDE HAS FAR LESS SIDE-EFFECTS

One distinguishable trait of amisulpride is that lower doses seem to only, or mostly block the dopamine D2S (autoreceptors) (2)  - which leads to an actual enhancement in dopamine release(3). Most of the usual antipsychotics we hear about, e.g risperidone, thorazine and haldol - all have very potent dual action dopamine receptor blockade(4). This leads to many more side-effects, including incidences of depression and high rates of drug-induced tardive dyskinesia(5).

Additionally, most anti-psychotic drugs have extremely potent alpha-1-adrenergic receptor blockade(6) (7), ami sulpride lacks this property, as well as the usual anti histamine property of anti-psychotics (8) - which means AmiSulpride is very unlikely to cause any form of sedation(9).

Usually, the anti-histamine properties of other anti-psychotic drugs combined with the alpha-1-blockade - acts as a one-two punch in knocking the patient out cold....frequently we hear about some of the affected even drooling on themselves or just completely incoherent and lethargic the following day(10)!

While some medical professionals consider this a benefit in hostile or unpredictable patients, I would find it much less than ideal for someone who wants to maintain somewhat of a normal life , not incapacitated but with symptoms controlled(11).

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~Back to amisulpride~

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Besides lack of side-effects, or at least lack of sedation - amisulpride has one very notable effect that sets it apart from other drugs in its class - it's anti-depressant effects are VERY FAST ACTING, very potent - and generally yield little to no negative endocrine effects(12).

The mechanism of action is totally unique, amisulpride binds to the serotonin 5-HT(7) with 11.5 nanomolar (ki/nm) affinity - this includes in human subjects(14).
It antagonizes the action of serotonin at this receptor - resulting in an anti-depressant effect that can not only augment other anti-depressants - but can be much more effective alone than many anti-depressants(15).

The additional benefits of 5-HT(7) antagonism are that it will reduce overstimulation and anxiety - as well as treat depression - and lower cortisol levels as well(16).

Because many depressed patients exhibit HPAA (hypothalamic-pituitary-adrenal-axis) dysfunction - and often have elevated cortisol - this unique mechanism of action may benefit the hormonal balance of depressed patients..(17) unlike SSRI's which tend to increase stress hormones (18) and oppose other beneficial neurotransmitters such as GABA, dopamine and others(19)!

Thus, in summary...

Amisulpride has the following benefits / advantages over other drugs aiming to do the same.

• A cortisol reduction, instead of increase.
• Enhances dopamine at lower doses.
• Little to no sedation, drowsiness, dyskinesia, tremors , punding or other disturbing side-effects.
• Doesn't interfere with cognitive function or vigilance.
• Treats depression quickly , and effectively.
• May improve anxiety symptoms as well.

5-HT1A Antagonists; Their Function, Benefits and Where to Buy Them Online

OVERVIEW OF 5-HT1A RECEPTORS

UPDATE: WAY 100 635 is now available.
-----------------HERE-------------------------------------

• This is a 5-HT1A antagonist known as the "gold-standard", chemically unique, and also has dopamine D4 agonist properties with no affinity for D2 autoreceptors.
• Studies show 10 mg minimum as a dose for humans and up to 45 mg at the maximum, effects may very per person.
• Provides cognition enhancing and may substantially increase nervous system strength and workout motivation.

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Certainly, besides the histamine H(3) autoreceptor/heteroreceptor - there is not one other G-protein coupled receptor, that has fascinated me quite like the serotonin 5-HT(1)A receptor.

This receptor is extensively studied because of it's well-known role as a central regulator across many neuronal networks - it is heavily intertwined with neuro-endocrine networks and plays a central role in the pathophysiology of depressive disorders as well as anxiety disorders and addiction(1) (2).

Particular interest in it's neuro-endocrine roles began in the late 80's to early 90's , with agonists such as 8-OH-DPAT and flesinoxan showing to release cortisol , prolactin, beta-endorphin and oxytocin(3) (4).


Since these neuro-hormones and peptides are distinctly involved in the regulation of GnRH (GonadoTropinReleasingHormone) neuron activity, it seems reasonable to consider the use of antagonists to increase testosterone levels(5). 

Additionally, 5-HT(1)A antagonists have shown to be useful in alleviating SSRI-induced sexual dysfunction ; and the studies display a primary role of this receptor in inhibiting the process of penile erection {SEE HERE}.
This includes the erectile responses induced by dopamine agonists(!). 

STRESS HORMONES AND SEX HORMONES REGULATE AVAILABILITY AND EXPRESSION OF 5-HT1A RECEPTORS

Interactions with specific hormones such as cortisol and estrogen have been documented. On the inverse, cortisol seems to regulate the amount of 5-HT1A activity (6) , estrogen seems to downregulate both synaptic forms of this receptor  (7)(PRE-SYNAPTIC & POST-SYNAPTIC). Testosterone and Androgens on the other hand, seem to enable 5-HT1A receptor function and / or normalize them during times of stress(8) (9) (10).

Before we get any further, you have to understand the difference between pre-synaptic and post-synaptic receptors.

        PRE-SYNAPTIC 5-HT1A RECEPTOR ROLE

Pre-synaptic serotonin 5-HT1A's are strictly AUTORECEPTORS (11) - that means they decrease the release of their given neurotransmitter or act on nerve terminals to inhibit the release of separate neurotransmitters.

In the 5-HT1A receptor terminals, they tell the brain to decrease serotonin release - acting as a sort of homeostatic feedback so that when the brain has too much serotonin - it can moderate/reduce it by these receptors.

Additionally, these 5-HT1A receptors are also somewhat intertangled with GABA networks...GABA is the primary inhibitory, and very calming neurotransmitter in mammals and humans. Serotonin specifically inhibits GABA - and especially does so in the PVN; Paraventrical Nucleus of the hypothalamus(12).....this effect likely accounts for some of the dopaminergic enhancement that may occur by stimulating the pre-synaptic receptors.  Conversely, antagonizing or blocking the pre-synaptic 1A receptors would enhance both GABA and serotonin..

                  POST-SYNAPTIC  5-HT1A RECEPTORS 

Post-Synaptic 1A receptors on the other hand - are expressed ubiquitously in the hypothalamus and hippocampus (rather than broadly distributed), their role seems to be a major focus for depression and anxiety. Post-Synaptic receptors (5-HT1A) tend to be anxiogenic (anxiety provoking) ( 13 ) and to inhibit male sexual responses to the presence of a female and thus inhibiting sexual behavior(14). Additionally, the activation of these receptors may have anti-depressant effects or paradoxically, hastening depression. An article by the scientific american states that blocking the 5-HT1A is the next phase in development of novel anti-depressant compounds or synergists for current anti-depressants(15).

BEHAVIORAL SEQUENCES AND CONQUEST TO BECOME A BETTER MALE

{Analogy with 5-HT1A Antagonists}

With these receptors, an increasing large barrier between becoming the ultimate male can be seen - additionally, aggression is usually REDUCED by 5-HT1A activation(16). However, these acts of aggression are also prominently dependent on psychology and social status.

The reasons we want to target and block 5-HT1A receptors are not just to alleviate depression or help prevent it from occurring , but also to disable negative feedback from corticosteroids, and yet to enable what I refer as the front-flipping, "keep going" cyclical gonadotropin continuance signal.

In simple terms, it means to enhance pulsatile secretion of both nitric oxide testosterone and to make one more immune to negative feedback and yet a better responder to things like hCG or other natural "testosterone boosters"(17) (18).

Because these receptors are heavily involved in both "regulating" dopamine, glutamate and testosterone output - the benefits of blocking them would include alleviating central nervous system depression, enhancing hormone production, and especially improving cognitive and intellectual functioning.

5-HT1A ANTAGONISM ALLEVIATES COGNITIVE DYSFUNCTION AND NMDA/GLUTAMATE DEFICIENCY

{CLICK HERE OR ON IMAGE TO GO TO STUDY}

BENEFITS OF 5-HT1A ANTAGONISM

• Alleviate depression(!).
• Boost testosterone(!) (!).
• Increase glutamatergic / NMDA mediated neurotransmission(!).
• Increase nitric oxide (!).
• Help to cure stimulant dependence.
• Reduce anxiety(!).
• Improve memory and some signs of dementia(!).
• Increase strength and aggression(!).
• Increase self-grooming / alleviate laziness(!).

UPDATE : WAY 100 635 is now available HERE. This compound is known as the "gold-standard" of 1A antagonists. It also has dopaminergic effects.

Your ideal candidates would be LECOZOTAN & WAY 100 635, I have not found a retail source yet...but when I do - I will update this article.

Additionally, way 100 635 functions as a dopamine agonist at the D(4) receptor - so that would be ideal for enhancing hormone function / libido aswell increasing oxytocin by modulating the serotonergic systems.

Challenging what you THINK You Know about the Neurological and Endocrine Causes of "Aggression"

I've always speculated it was more complex than what media reports had to say - I always saw the idiocy in trying to blame one hormone, or one neurotransmitter for the basis of aggression; both offensive and defensive. Moreover, I've seen the hypocrisy and diluted information that seems to be injected into the public as a collaborative  effort , whether for or against any particular group, it really doesn't matter.

I find mainstream science to be a little boring  ~anyhow~.


Fortunately, I haven't lost my grasp on any of this, and I haven't stopped studying.

If YOU want answers in life, you need to know how to read "between the lines" - you need to be able to ANALYZE, DISSECT, and properly divide all information you should be retaining. A little logic and common sense never hurt anyone either.

Here's what WAS in my periphery, years ago...

"Given the number of men who have used or trialed a selective estrogen receptor modulator such as CLOMID; and the outstanding number of reports both IN and OUT of "study" - of increased aggression....I took a firm heart with a good bet that estrogen IS IN FACT THE NUMBER ONE AGGRESSIVE CLOWN IN HUMAN BIOLOGY."

We all know what it looks like when an emotionally disturbed young man goes on a rampage ------- like Elliott Rodger - but how would we classify this?

....And don't even think about telling me the bullshit of "OH HE'S A BOY - IT MUST BE THE TESTOSTERONE", does this kid really look TESTOSTERONE FUELED TO YOU!!??

AND YET...he "dud gone and did them dastardly acts" ...no they are UNSPEAKABLE.

So that should alone, or in combination with the other stories, which, I MUST SAY, are the cinnamon on your apple fritters - should put a crap on THE GARBAGE HYPOTHESIS of TESTOSTERONE involvement in the loosely efforted and openly thrown word "AGGRESSION"

How about females with high estrogen levels, these aren't exactly, calm creatures....are they !?

                                  

But you haven't seen my point YET, oh no...NOT YET.

Grab some popcorn and stay a while , will ya?

Now that we've moved past with fancy stuff, here's an ACTUAL STUDY, yes, you heard it right, a STUDY on estrogen's PRIME ROLE in AGGRESSION - IN BOTH MEN AND WOMEN.

Estrogen link in male aggression sheds new light on sex-specific behaviors

IS "FEMALE" HORMONE A KEY FACTOR IN MALE AGGRESSION?

HERE's another one showing the roles of NORADRENALINE AND PSYCHOTROPIC DRUGS - being a "key factor" in human aggression.

Just one question...

At what point of ADRENALINE THRESHOLD do people BECOME INTOLERANT!?

Stress in society certainly contributes...

Do we REALLY NEED amphetamines in an organized study to tell us ADRENALINE; "THE FIGHT OR FLIGHT" neurotransmitter can CAUSE or AMPLIFY aggressive tendencies??

Or just 1,000,000 studies to show the relevance in total drug ADDICTS?

MIND YOU, there's a DIFFERENCE BETWEEN SCIENTIFIC STUDY, And CALIBRATED OPINIONS!!!

Add insult to injury and with a cascade of PSYCHOTROPIC DRUGS and a lack OF SOCIALIZATION, and becoming a MAN - AND ALL OF A SUDDEN YOU HAVE RADICAL SNOWFLAKES going around saying "I AM GOD". - whilst they shoot up their intended targets and dream about their unsapien like ENDEAVORS in the next life!

Interestingly, I s'pose this kid *COULD HAVE* had a lack of nitric oxide in his veins, or brain, and thus DISINHIBITED , adrenaline like-RESPONSIVE behavior....as the following book/study shows that lack of nitric oxide is key to understanding aggression - and often RESULTS in DISTORTED neurotransmitters!

Of course there's the idiotic argument of "WHY THEN DO SO MANY MASCULINE LOOKING DUDES HAVE SUCH AGGRESSION AND ARE COMMONLY ANTISOCIAL" - but no one really ever digs INTO the life to see what TRAUMAS were submerged for years upon end, or perhaps no one cares!?

No, you see, THEY JUST WANT AN EASY ANSWER!!

The same to the original neuro-biological basis for aggression - SEROTONIN's role is quite debatable, actually..... IRONICALLY it's the AUTORECEPTORS that DECREASE aggression ----what are AUTORECEPTORS? They Simply tell the Brain to PIPE DOWN the production or use of  their respective neurotransmitter - in THIS CASE , serotonin.

Hat's off to the people behind this study.

WHAT THAT MEANS is SEROTONIN being DECREASED is actually CALMING AGGRESSION....it's serotonin that is CAUSATIVE of Aggression when it binds to it's STIMULATORY receptors....which actually constitutes 5-HT2, 3A, 4A, 5A and type 7 (5 out of 7 serotonin receptors are STIMULATORY).

Can we kill the generalizations now ?
{ CLICK ON THE IMAGE TO GET A BETTER VIEW }

EPITALON - A breakthrough novel tetrapeptide with Telomerase activating and Pineal Gland Modulating Effects - And a Worthy candidate to be called the "Fountain of Youth"

This article has been exclusively written for TrueLIFE Research - TeamTLR.com and to foster further progress within research utilizing the incredibly valuable anti-aging compound - EPITALON.

-------------------------------------------------------------BUY EPITALON at link below-------------------------------------------

http://teamtlr.com/anti-aginglongevity-research/77-acetyl-epitalon-ac-epi-98.html

------------------------------------------------------------------------------------------------TeamTLR HomePage-------------------


Epitalon is a wondrous tetra peptide with telomerase activating, telomere elongation, and cellular rejuvenating properties - thus having immense ant-aging potential(1)(2). It, and the concept of telomere's/telomerase, are a  subject frequently talked about in great enthusiasm by a plethora well-respected scientists, doctors and researchers(3)(4). Dr.Ed Group ; a scientist & Doctor, well known by his appearances on the "Alex Jones Show" and other talk shows - has elaborated and expanded on, the importance of telomere's/telomerase in aging and cellular health(5)(6)(7).

Now , a quote from Center of Genetic Studies, university of Utah.

Inside the nucleus of a cell, our genes are arranged along twisted, double-stranded molecules of DNA called chromosomes. At the ends of the chromosomes are stretches of DNA called telomeres, which protect our genetic data

Professor Vladimir Khavinson (RU) is another esteemed expert on this topic - also asserting the relevance and significance of peptides and their " selective"interactions with telomeres being vital in understanding aging and general health. An incredibly popular write-up of his "Peptide regulation of ageing" beautifully explains all of this. "Bulletin of Experimental Biology & Medicine" is another great work of his; it mentions that an additional benefit of EPITALON is stimulating melatonin production and normalizing cortisol levels and circadian rhythms.

Thus, epitalon is one of the only scientifically supported compounds that has measurable, safe , but profound activities in the Pineal Gland; a region of the brain that is of increasing research and study today - in that it controls and regulates neuronal tone and sleep/wake cycles.

The Pineal Gland is such a big topic; that it has accumulated many alternative nicknames; in many instances being dubbed "God's Antenna" - and being referred to as a gland that determines spiritual essence and vigor. Many channels on youtube are dedicated to "activating" the pineal gland by showing vibrating and shape shifting, centered images and specific "auditory vibrations" that may have some appeal to those looking for sensory based relaxation/meditation.

Therefore, these subtle reports and anecdotes are yet another reason why epitalon or any substance with regard to the pineal gland - are going to attract, inevitably, quite a bit of attention.

Of course, one shouldn't be overly concerned about anecdotes, or even merely the existence of peptides or other chemicals that have affinity for pineal receptors or that have the ability to influence pineal gland secretions - at least solely, one massive amounts of research get the message across much smoother.

Let's go back to more information about epitalon - with a bit of a larger explanation.



Epitalon is revolutionary, in that it not only has specific membrane activity, but can elicit beneficial effects on just about every organ/tissue without negative side-effects. It's ability to rejuvenate and repair, along with being a DNA protector - is remarkable , to say the least. It even takes up a number of discussions on well-known and respectable forums involved in the life extension enthusiast and movements. ( example here )

It's acetylated variant (acetyl is a molecule addition that makes a substance better able to cross blood brain barrier (!) ) has been to improve neuronal and cognitive function - especially that associated with the loss of cells or an impaired regeneration of nerve cells/myelin sheaths(8).

Additionally, it was shown to be able to preserve retina function and reverse abnormalties(9) and act on pineal nerves to protect cellular integrity and reverse some signs of aging(10) (11) (12).

It has endocrine balancing and tonic effects (13) - helping to repair damage to central area's of the hypothalamus - and thus alleviating stress-related decrements (14) in hormone secretion and returning the balance of stress hormones and other hormones in the body(15). It also prevents immune suppression related to stress(16).

Finally, not only does epitalon have immune protective and endocrine rejuvenating effects, but it may also have effects against specific oxidative stress, play a role in antioxidant enzyme release (!) - and function as an overseer of metabolic processes and cellular tone(17)(18).

In summary, Epitalon is an amazing anti-aging peptide that works on all levels of cellular health and in DNA repair. The following benefits are noted.

• Activating telomerase.
• Elongating telomere's.
• Promoting cellular survival and resistance to stress and oxidative changes.
• Balancing endocrine secretions, rejuvenating pineal gland function and increasing melatonin release.
• Specifically attenuating excess cortisol secretions from the higher level.
• Can increase antioxidant enzymes.
• Increase brain health, stave brain cell aging / remodeling.
• Restore quality of life and extend the lifespan by all above mechanisms.

TAL; Taltirelin (TA-0910) - A potent Dopamine Secretagogue and "SuperAgonist" at the human thyrotropin-releasing hormone receptor (TRH-R1)

This article has been exclusively written for TrueLIFE Research - TeamTLR.com and to foster further progress within research with the valuable compound Taltirelin; TA-0910.

It can be purchased at their home page > http://teamtlr.com/anti-aginglongevity-research/98-taltirelin-98.html

Out of all the innovative nootropics and certainly worthy to be placed in the most popular Dopaminergic Pot of Gold article, nothing stirs quite the amount of attention as the dedicated science behind a new superagonist at the human thyrotropin-releasing hormone receptors (TRH-R1) - TALTIRELIN , abbreviated as TAL.

Though Taltirelin (marketed under the tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog - it has a much longer half-life and duration of action than natural TRH(2).

One of the first cited studies back in 2002 shows this chemical, taltirelin, to be neuroprotective(3).
This effect was exerted even with models of ischemia (!) and other conditions that are hard to treat.
However, studies on it's neuroprotective, and moreover, pro-cognitive / nootropic effects date back to 1997 ; where it was demonstrated to have ameliorated consiousness impairment, memory impairment and motor dysfunction in several models(!).

In 2007, a much larger study showed taltirelin to be a potent antinociceptive ( (pain relieving) ) as well, an effect at least partly, but certainly not solely - dependent on the indirect activation of serotonin 5-HT(1)A receptors(SEE STUDY HERE).

The larger wonders of this chemical began in 2013,with tests showing marvelous anti-depressant effects(4) and even more significant, the demonstrations of it being almost unprecedented, and even comparable to methamphetamine (but not dangerous and without adverse events) in inducing/increasing dopamine release(!).

It was also demonstrated to have acute and chronic memory enhancement effects, and could ameliorate memory impairment on a central hypothalamic level, and by directly modulating cholinergic neurotransmission in the hippocampuls ; a brain area largely involved with spatial, active and declarative memory(!).

An anti-ataxic effect of taltirelin was noted as well - an effect that probably has to do with NMDA-glutamate receptor modulation/activation, as this benefit was blocked by an NMDA-antagonist; MK-801-------------(5)(6).

Taltirelin was also revealed to have neurotropic; brain cell increasing and synapse regenerating effects - this occurred at the molecular and central level - and most profound effects were seen in the spinal cord - though it was also noted to reverse nerve damage in other tissues/brain regions(7).


---------------------------------------Taltirelin's effects on NEUROTRANSMISSION-----------------------------------------
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• Taltirelin increases extracellular levels of acetylcholine in the hippocampus, but modulates turnover if levels are already high (potentially protecting against excesses of ACh as well).
• Taltirelin increases noradrenaline in the hypothalamus.
• Taltirelin super-potently increases dopamine release in the striatum and nucleus accumbens - which are area's involved in motivation and as such this is likely the responsible action for it's pungent anti-depressant effects.
• The compound also can regulate/increase serotonin levels in the brain stem. nucleus accumbens and striatum. 
• Taltirelin may increase neurite outgrowth via distinct modulation of neurotrophic factors and via positive effects on blood flow.

In summary, TALTIRELIN; marketed as  Ceredist and often referred to as TA-0910 - has the following effects/benefits.

• As an anti-depressant(!)(!).
• As a nootropic(!).
• Ameliorating memory deficits, and increasing retention(!).
• As a novel analgesic/pain reliever(!).
• As a stimulant - with motivation increasing effects(!) (!).
• Regenerating spinal cord nerves and treating spinal muscular atrophy(!). 
• Rapidly increasing dopamine, noradrenaline, serotonin and acetylcholine(!)  (!).