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Monday, February 9, 2015

TAL; Taltirelin (TA-0910) - A potent Dopamine Secretagogue and "SuperAgonist" at the human thyrotropin-releasing hormone receptor (TRH-R1)

This article has been exclusively written for TrueLIFE Research - and to foster further progress within research with the valuable compound Taltirelin; TA-0910.
It can be purchased at their home page >

Out of all the innovative nootropics and certainly worthy to be placed in the most popular Dopaminergic Pot of Gold article, nothing stirs quite the amount of attention as the dedicated science behind a new superagonist at the human thyrotropin-releasing hormone receptors (TRH-R1) - TALTIRELIN , abbreviated as TAL.

Though Taltirelin (marketed under the tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog - it has a much longer half-life and duration of action than natural TRH(2).

One of the first cited studies back in 2002 shows this chemical, taltirelin, to be neuroprotective(3).
This effect was exerted even with models of ischemia (!) and other conditions that are hard to treat.
However, studies on it's neuroprotective, and moreover, pro-cognitive / nootropic effects date back to 1997 ; where it was demonstrated to have ameliorated consiousness impairment, memory impairment and motor dysfunction in several models(!).

In 2007, a much larger study showed taltirelin to be a potent antinociceptive ( (pain relieving) ) as well, an effect at least partly, but certainly not solely - dependent on the indirect activation of serotonin 5-HT(1)A receptors(SEE STUDY HERE).

The larger wonders of this chemical began in 2013,with tests showing marvelous anti-depressant effects(4) and even more significant, the demonstrations of it being almost unprecedented, and even comparable to methamphetamine (but not dangerous and without adverse events) in inducing/increasing dopamine release(!).

It was also demonstrated to have acute and chronic memory enhancement effects, and could ameliorate memory impairment on a central hypothalamic level, and by directly modulating cholinergic neurotransmission in the hippocampuls ; a brain area largely involved with spatial, active and declarative memory(!).

An anti-ataxic effect of taltirelin was noted as well - an effect that probably has to do with NMDA-glutamate receptor modulation/activation, as this benefit was blocked by an NMDA-antagonist; MK-801-------------(5)(6).

Taltirelin was also revealed to have neurotropic; brain cell increasing and synapse regenerating effects - this occurred at the molecular and central level - and most profound effects were seen in the spinal cord - though it was also noted to reverse nerve damage in other tissues/brain regions(7).

---------------------------------------Taltirelin's effects on NEUROTRANSMISSION-----------------------------------------

  • Taltirelin increases extracellular levels of acetylcholine in the hippocampus, but modulates turnover if levels are already high (potentially protecting against excesses of ACh as well).
  • Taltirelin increases noradrenaline in the hypothalamus.
  • Taltirelin super-potently increases dopamine release in the striatum and nucleus accumbens - which are area's involved in motivation and as such this is likely the responsible action for it's pungent anti-depressant effects.
  • The compound also can regulate/increase serotonin levels in the brain stem. nucleus accumbens and striatum. 
  • Taltirelin may increase neurite outgrowth via distinct modulation of neurotrophic factors and via positive effects on blood flow.

In summary, TALTIRELIN; marketed as  Ceredist and often referred to as TA-0910 - has the following effects/benefits.

  • As an anti-depressant(!)(!).
  • As a nootropic(!).
  • Ameliorating memory deficits, and increasing retention(!).
  • As a novel analgesic/pain reliever(!).
  • As a stimulant - with motivation increasing effects(!) (!).
  • Regenerating spinal cord nerves and treating spinal muscular atrophy(!). 
  • Rapidly increasing dopamine, noradrenaline, serotonin and acetylcholine(!)  (!).

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