I just wanted to quickly discuss one of the biggest issues
today which is male pattern baldness.
Many doctors prescribe 5-alpha reductase inhibitors which prevent
testosterone from converting into DHT.
Although, this does help to stop or slow down MPB, this isn’t the root
cause and would be the last thing you would want to do as a male. You need DHT for many functions within the
human body, but I’m not going to get into that in detail as there has been a
previous article addressing all of the important functions of DHT.
One of my buddies who is very well known in the hair loss
community called “Swiss Temples” began experimenting with a new method called
the “prostaglandin approach”. This
approach was heavily influenced by top hair loss researchers in the field like
George Cotsarelis MD, who is the head of dermatology at the University of
Pennsylvania and Dr. Luis Garza of Johns Hopkins University.
What is the prostaglandin
approach?
Testosterone-->DHT--->PGD2--->Miniaturizes
follice and dies
·
What we focus on is inhibiting PGD2, basically
we are stopping the source of the follicle causing to die rather than lowering
DHT. High DHT = High PGD2.
·
A balding scalp has high levels of PGD2 (bad=
causes hair loss) and low levels of PGE2 (needed for hair growth)
Here is a more
detailed summary of how the protocol works:
1. Plain old hormonal DHT -> PGD2 -> PGJ2 killer inflammation. Preventing neogenesis and new formation of anagen.
2. Direct expression of PGD2 -> PGJ2 killer inflammation from already bald scalp/lost hairs. This is why removing androgens alone does not regrow hair and why almost nothing works to regrow hair on slick bald areas. The affected scalp is "genetically dead" and releasing harmful prostaglandins due to enzymatic PTGDS havoc.
3. Lack of cd34 and cd200 progenitor cells preventing *physical* growth of hair. These are absolutely crucial for the actual growth of hair. Normal scalp with hair is rich in both. Prostaglandin/genetically damaged scalp has none of these.
4. Lack of beneficial Prostaglandin expression. PGE2 and subsequently PGF2a and some others won't be created in dead scalp tissue due to genetical PTGDS over-expression already converting the PGH2 precursor into harmful prostaglandins (PGD chain) instead. Think of it like a cross road with all the traffic being led into the wrong direction.
1. Plain old hormonal DHT -> PGD2 -> PGJ2 killer inflammation. Preventing neogenesis and new formation of anagen.
2. Direct expression of PGD2 -> PGJ2 killer inflammation from already bald scalp/lost hairs. This is why removing androgens alone does not regrow hair and why almost nothing works to regrow hair on slick bald areas. The affected scalp is "genetically dead" and releasing harmful prostaglandins due to enzymatic PTGDS havoc.
3. Lack of cd34 and cd200 progenitor cells preventing *physical* growth of hair. These are absolutely crucial for the actual growth of hair. Normal scalp with hair is rich in both. Prostaglandin/genetically damaged scalp has none of these.
4. Lack of beneficial Prostaglandin expression. PGE2 and subsequently PGF2a and some others won't be created in dead scalp tissue due to genetical PTGDS over-expression already converting the PGH2 precursor into harmful prostaglandins (PGD chain) instead. Think of it like a cross road with all the traffic being led into the wrong direction.
So how do we
address each one of these points?
For number 1 & 2, you need a PGD2 inhibitor. A compound called Setipiprant is being
heavily researched by Dr. Cotsarelis and Kythera.
It has been through many clinical trials and is very safe. Most importantly it does not cause side
effects like ED, lowered sex drive, brain fog etc since it doesn’t affect your
hormones (DHT). At extremely high doses,
Setipiprant could cause headache or insomnia.
I personally have been using Setipiprant for about a week now orally and
had no side effects. My shedding and
itching has pretty much stopped. Let me
remind you I’m not taking anything else like finasteride since it gives me side
effects. This essentially does will stop
your loss or “maintain”.
For number 3, you need to do something called
wounding/needling by using a 1.5mm dermaroller or derminator. This is essentially stimulating growth factors
in your scalp to bring it back to its pre-balding state. This will stimulate CD34 and CD200 progenitor
cells. Also, another way you could
promote CD stimulation is through a chemical called stemoxydine. It’s on Amazon called Neogenic.
For number 4, you need to increase PGE2 by using real
exogenous PGE2. This will promote the
hair growth aspect since balding scalps have low amounts of PGE2.
In summary, you need to lower/inhibit PGD2 and increase
PGE2. By lowering PGD2 you stop the hair
loss and by increasing PGE2 will stimulate hair growth. Also, you need to stimulate CD progenitor
cells on the scalp (number 3) to help bring the scalp to it’s pre-balding
state. Now there is virtually no side
effects of this approach and you are actually addressing the route cause for
hair miniaturization instead of messing with your hormones. If you are on 5AR’s or AA’s and they are
working fine for you then stay on them and add this protocol. If you are on nothing or 5AR’s/AA’s give you
sides, give this protocol shot.
For reference, I would suggest reading this links below and
most importantly check out Swiss Temples blog where you can see the results
(pictures) for yourself.







