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Thursday, November 24, 2016

Does Masteron (DHT, Drostanolone Propionate) Lower / Decrease Cortisol Levels?

"Area, does Masteron have an effect on Cortisol? Does it decrease cortisol levels?"

~Dave Q

Research shows that Dihydrotestosterone inhibits the HPTA stress response by cross-activating estrogen-Receptor beta, this causes a decrease in circulating corticosteroids, strong compounds, like Masteron, tend to have direct blocking action on Cortisol, by acting both at the hypothalamus and by acting on beta-endorphin related pathways [!].

So Yes, Masteron absolutely can lower Cortisol levels. 

Perhaps not as much as more ''official'' cortisol blockers, but it does to an extent.


Horm Behav. Author manuscript; available in PMC 2013 Jan 1.
Published in final edited form as:
Horm Behav. 2012 Jan; 61(1): 147–155.
Published online 2011 Oct 1. doi:  10.1016/j.yhbeh.2011.09.010
PMCID: PMC3264812

J Neurosci. 2006 Feb 1;26(5):1448-56.

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