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Thursday, October 6, 2016

Natural / Herbal Tryptophan Hydroxylase Inhibitors (Supplements to Block/Reduce TPH in Brain)


As always Area-1255 is here with another project of Innovation. This time we are going to discuss tryptophan-hydroxylase inhibitor supplements. That is, the only supplements on Earth studied to actually decrease the amount of serotonin being produced in the brain by directly inhibiting the serotonin producing enzyme tryptophan hydroxylase

There are a few reasons we would look to ''inactivate'' or 'inhibit' tryptophan hydroxylase (TPH).


  1. Some people are naturally born with more serotonin or less breakdown of serotonin, this can lead to disorders like Social Phobia [1], Obsessive-Compulsive-Disorder [2], as well as cognitive dysfunction [3] and Anorexia [4] [5]. In susceptible individuals, of course, so therefore, TPH-Inhibitors may be of interest in those looking to try a natural alternative before switching to a synthetic compound. 
  2. TPH-Inhibitors may help delay or reduce fatigue and exercise-induced fatigue [6] [7], thus they are of value to those trying to increase their fitness level and consistency.
  3. TPH-Inhibitors may improve libido and sexual functions in men and women [8] [9].
These are the most prominent uses for TPH inhibitors but they are not limited by these uses. There are still many investigative uses that could be relevant, but for our purposes and for the herbs we are describing, these are the most notable.

There are really only 3 `real` tryptophan hydroxylase inhibitors that are over-the-counter, do not require a prescription, and are EASILY obtainable. 

:::..::..:::...CLICK the [!] Symbol to Explore the Source of Information Pertaining to the Herb in Question...:::..::..:::

1.) Eleuthero Root Extract [!] (Also known as "Siberian Ginseng" and by botanical names of Eleutherococcus senticosus & Acanthopanax senticosus).

Pro's
  • It boosts energy fairly reliably.
  • It is significant enough that it is put in many energy drinks.
  • It seems to definitely delay fatigue and increase endurance.
  • It increases social aggressiveness when taken long-term.
  • It has a stimulating effect on the mind.
Con's.
  • It can cause Insomnia.
  • It can increase anxiety if too high a dose is taken.
  • It has pro-adrenaline effects as well as anti-serotonin.
  • It causes constipation in some people.
  • It can increase cortisol.

Read this paper on it as well.

You can buy the herb extract in capsules HERE.

2.) Arginine Nitrate; L-Arginine blocks hypothalamic serotonin induced or activated by IL-1B (Interleukin-1β) [!] and it helps produce nitric oxide which directly inactivates tryptophan hydroxylase [!!].

I would buy a product like PES High Volume which is an overall nitric-oxide booster ("pump product") and has a lot of other stuff (+arginine nitrate) that helps increase physical, sexual and mental performance plus it tastes like cotton candy :-)  .

                       CLICK HERE for the Best deal on buying it.


3.) Paeonia Radix Extract (Bai Shao Yao) [!] : One of the more powerful herbal tryptophan-hydroxylase inhibitors out there, about on par with eleuthero but without the adrenergic activity. It can be bought primarily as a tea or decotion which is easily digested and tastes fair, not tasty, but fair, tolerable. CLICK HERE to Buy it.

I haven't really heard of a whole lot of people who have used it for this purpose so it's a bit difficult to list a bunch of pro's and con's but given the constituents of the herb it definitely seems to be more clean and linear in terms of it's mechanism of action. 

The only concern would be that at higher-doses only it may have some estrogen-like effects.



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