Advances in the BioChemical Realm of Neuro-Endocrine Enhancement 2018 (How to Enhance/Maximize Testosterone Production Artificially 2018)

Neuroendocrine 'Enhancement' is defined as enhancing the Neurotransmitter-Endocrine System to achieve a Maximal Hormone Production - while more easily achieving Homeostasis. In Effort - it is simply Achieving the highest level of Health, Motivation and Personal Vitality.

NeuroEndocrine enhancement can be both Natural & Synthetic (Pharmaceutical Drugs) - and most Experts agree that Synthetic Products have more Research behind them.

Today - and beyond as this Article is finished, we will go over the Vital Aspects and advances in NeuroEndocrine, Hormonal, Motivational & Sexual Enhancement.

1. In our Previous Post - we looked into the Histaminergic Aspect of Endocrine Health & we explored its Effects on Motivation & Sexual Desire. Where we also Referenced Studies that allowed Us (and Readers) to fully Grasp how to modify these pathways that would allow us to Achieve greater Health and Sexual Function.
2. In another post - called "World's Strongest Aphrodisiac/Sex Pill 2018" - we dove into the Aspects of Sexual Enhancement through Up & Coming Research Universities. Where all types (Central & Peripheral) of Enhancement were Studied.
3. We looked into Enhancement of Testosterone Production (On-All-Levels) by Carefully Researching ALL-STUDIED Metabolic Pathways involved in Testosterone secretion.
4. We went over how most Testosterone Boosters are COMPLETE Crap - except Well-Reviewed Testosterone Booster Products (2018) like - Test-Stack Product No.17.
5. We spent time exploring the Concept of Androgens & Estrogen in maintaining Peak Health and the ability of Anabolic-Steroids (Purchase @NapsGear) to Absolutely REMOVE Symptoms of Depression within Days of Use.

However, while Anabolic-Steroids are certainly "Enhancing" in many ways...they also present a Fair amount of Risks in the Enhancement Process....

Thus...we are not in the habit of Recommending them as a form of Endocrine-Enhancement - and Steroids generally work in a direction of unhinging Endocrine Homeostasis - hence why Infertility, sometimes even Permanent Infertility is a common occurrence in Steroid Users [8] [9] [10] [11].

Besides - IF we DON'T think Outside of the Box - this wouldn't really be 'New' or Exciting at all...would it?

The Concept of Manipulating the CNS to Pump Out MAXIMAL amounts of Gonadotropins and Hormones is certainly a Complex One...but it can be done with a few easy tools.

In order to Understand the Concept of Endocrine-Maximization...you have to understand there are...

• Facilitating Factors; Hormones and Neurotransmitters that "ignite" the Hypothalamus; those of Histamine, Glutamate, Dopamine, Nitric Oxide - primarily. Neuropeptides such as Melanocortins, Oxytocin and Ghrelin play facilitating roles. 
• Inhibitory Factors; Neurochemicals that play an Opposite Role and decrease Hormone Synthesis and vital proteins. This would be Serotonin, Prolactin, Cortisol, Cannabinoid-Receptors, Melatonin, Kynurenic Acid and GABA - among others.

To manipulate the neurological systems - we have to be able to SHIFT all of these Neurotransmitters in the "Right Direction"...

The only way to do that, is to understand the Biochemical Pathways involved in the Synthesis of these neurotransmitters.

1. Serotonin is made from the Amino Acid 'L-Tryptophan' and the Enzyme "Tryptophan Hydroxylase" or "TPH" [12] [13]. Which comes in two forms; TPH1 [14] and TPH2 [15]. If we can 'outcompete' the Tryptophan by introducing "large-neutral amino acids" such as BCAA's [16]. Then we can permanently shift the Dopamine:Serotonin balance - in favor of Dopamine. 
2. Melatonin is synthesized from Serotonin, via additional Enzymes; Serotonin N-acetyltransferase & Acetyl-CoA [17] [18]. 
3. Cannbinoids are synthesized via multiple pathways and use multiple substrates - the Naturally Produced Endocannibinoids (not to be confused with Marijuana/THC) are known as 2-arachidonoyl glycerol (2-AG) & Anandamide (arachidonoyl ethanolamide) [19].
4. Then, Prolactin is synthesized by the Pituitary; typically when Dopamine is too low to stop Prolactin from being released; as Dopamine is known as the "Prolactin-Inhibiting Hormone" [20]. Estrogen (the female hormone) reinforces and provokes Prolactin (PRL) release [21].
5. In studies - Dopamine Agonist Drugs are known to increase Gonadotropins and Libido [22]. They are, in fact, Prominent Cures for Sexual Dysfunction caused by Anti-Depressants (SSRI's etc) [23] [24] [25].
6. Kynurenic Acid (KYNA or KYN) - Kynurenic Acid suppresses Glutamate and DIRECTLY blocks the Pro-Hormone Secretion Receptor - the NMDA-Receptor [26] [27] [28].
7. Since Glutamate, the Primary Neurotransmitter in Our Brains & Bodies - evokes (creates) the Resting & Spontaneous Gonadotropin-Secretion [29] [30] [31] - it is CRITICAL that Glutamate is not being blocked by other Chemicals in Our Body; such as Serotonin - which blocks Glutamate [32] and again, Kynurenic Acid - which (ultimately) comes from Serotonin [33].
8. Other "controls" such as GABA can 'selectively' or situationally inhibit/Block LH/FSH - which stimulates Hormone Secretion in both Men & Women [34]. Hence, why Benzodiazepines [!] or GABA-Action Type Drugs; used Clinically for Anxiety - can cause Erectile Dysfunction [35]. Neurontin (GABAPENTIN) [36] and Lyrica (Pregabalin) [37] can also cause Immense Sexual Dysfunctions - again reinforcing the Role of GABA as an 'ANTI-HORMONAL', anti-Sexual Neurotransmitter [38] [39] [40].
9. Although Melatonin can have 'Protective' effects on Sexual FUNCTION [41] - it is generally inhibitory in the sense that its Receptors decrease the Secretion of Male Hormones [42]. Melatonin is, however, ESSENTIAL to sexual Maturation and going through Puberty [43]. Melatonin is also critical in sustaining antioxidant activities [44] - so its activities should not be ELIMINATED or Abolished altogether. Melatonin moreover can play permissive Roles in Female Sexual Function [45].
10. Nitric Oxide is the BIGGEST, most important factor in the Interplay between Dopamine and Sex Hormones - it is Not Only CRITICAL for Sexual Functions...but for Men to have Kids/Children Period [46] and is necessary for the Testicles to produce proper amounts of Testosterone [47] - it is also involved in BOTH the Male & Female Libido [48].
11. Lastly - the Melanocortin-Pathway...as evidenced by the Tanning Drug MELANOTAN II and its ability to induce Spontaneous (RANDOM) Erections in Men [49] - and its successor; PT-141 now known as the "Sex Drug of the 21st Century" - illustrate quite Clearly, that Melanin [50] (the tanning hormone) and its Relative Hormones - the Melanocortins - can ACTIVATE the Hypothalamus in the Brain - which secretes Sex Hormones [51]... This is also Evidenced by the FACT that Black Men (African/African-American Men) have Higher Testosterone [52] and higher libido's [53] (generally). 

OTHER NOTES: The Melanocortin Pathway (MCR4) also controls general and Work-Related Ambitions/Motivations [54] as well as Activates Sexual Function in Men & Women [55].

By addressing all of these Pathways we can Effectively Accomplish a State of "Enhanced" Hormonal Release...many of these Methods are literally DIRT-CHEAP. So it doesn't cost a whole lot to Tap-In to these Methods.

1. Use BCAA (Branched-Chained-Amino-Acids) + N-Acetyl-L-Tyrosine - to Enhance Dopamine while simultaneously lowering Serotonin levels in the Brain [56] [57] [58].
2. Inject PT-141 before Sex, but also Recreationally - 2 or 3 times per week. To keep hypothalamic-output going STRONG.
3. Inhibit GABA by raising Histamine levels [59] - you can supplement with 2,000 MG (miligrams) of L-Histidine - which in itself, when converted into Histamine - DIRECTLY stimulates the Hypothalamic-Gonadal Axis and Hormone Secretion [60].
4. By using L-Histidine and also Niacin, daily, you can sustain Optimal Histamine levels in the Brain [61].
5. You can simply supplement with Mucuna Pruriens 40% L-Dopa Extract - to DIRECTLY stimulate Dopamine Receptors [62].
6. You can also supplement with Kutaja Bark - which is an 'Herb' which stimulates Histamine Activity and the hypothalamus [63] [64] [65].
7. You can maximize The Amount of Dopamine-Receptors - so that Dopamine can DO more of its Activities and (PROPERLY) stimulate Hormone Release - you can do that by Supplementing with 13 Grams of Inositol per day [66] as well as Supplementing with something called "Forskolin Extract" [67] [68].
8. You can MAXIMIZE Nitric-Oxide in the Hypothalamus by supplementing with 12 grams of L-Arginine, per day - which both increases LH-Release [69] AND Growth Hormone levels [70] - and which ALSO Reduces Serotonin in the Hypothalamus [71] - which, of course, will stimulate more Testosterone & Hormone Secretions [72] [73] [74]. You can also stimulate the Activity of the Enzymes that increase Nitric Oxide production FROM L-Arginine - you can do that by Supplementing with Kyolic (Garlic) Circulation formula along with Vitamin C (Ester-C + Vitamin C, preferred). Using both together is Scientifically PROVEN to Enhance Nitric-Oxide Levels and Synthesis [75] [76]. This combination - in the same HUMAN STUDY - lowered Blood Pressure significantly. So its worth it to simply add them both in - you can ALSO choose to simply EAT 4-Whole Garlic Cloves per day, which is just as Effective in Lowering Blood Pressure (BP) as Garlic Supplements [77] [78] [79].
9. You can improve TOTAL Hypothalamus activity by Stimulating Neurogenesis or...Growth of New Brain Cells & Synapses - the MOST EFFECTIVE way to actually Increase BRAIN VOLUME and Neuron Amounts - is to Supplement with the Nootropic Drug; DIHEXA - which Rebuilds Dopamine-Neurons within a few days of use [80].
10. If you are the type who DOESN'T show your Emotions much - or doesn't have much Love, Compassion, Trust or Mercy in your Heart - AND you also happen to suffer from Symptoms of Low Testosterone and Low Libido/Erectile Function...chances are you are low in a Hormone called OXYTOCIN [81] [82] [83]. Oxytocin stimulates Testosterone production in the Testicles of Man [84], so being LOW on Oxytocin will almost certainly result in Low Testosterone ("Low-T") or even TOTAL Hypogonadism. To increase Oxytocin - the most surefire way is to simply use Oxytocin-Nasal Spray (BUY-HERE) [85].
11. Lastly - you can Optimize the ENTIRE Hypothalamic Axis by eliminating the Opioidergic-Reduction of LHRH and Neurohormones. You can do this - Simply by drinking InfoWar's Organic Coffee - as Coffee contains chemicals that block Opioid-Receptors in the Brain [86] [87] [88]. Then - you should take the drug Naltrexone - 3 Days per week at 25 MG-50MG per day. This will further block Opioid-Receptors and will STIMULATE Sexual Function & Hormone Release, INTENSELY & IMMENSELY. Additionally - the InfoWars 'Immune-Support' blend can actually EXTEND Lifespans as it has an Ultra-Rare form of a Mushroom Extract called "Reishi Mushrooms" also known as the 'Mushroom of Immortality' and 'Food of The Gods'. The Mushroom of Immortality is one path to extending the Human Lifespan and Optimal Hormonal and Dopamine Function, forever [89]. 
12. OPTIONAL: You can also take a drug DAILY called Selegiline (Deprenyl) which is an MAO-B Inhibitor - which is well-known to ENHANCE Testosterone AND Growth Hormone levels in Men & Women [90] [91] [92]. Selegiline also enhances Motivation and BLOCKS Depression in nearly EVERYONE who takes it [93] [94] [95]. Selegiline too, is an Anti-Aging drug that can be used to Extend Lifespans by 34% [96] [97] [98].

Other Aspects - The Histamine H4-Receptor and cAMP-PDE Enzymes.

1. The Histamine H4-Receptor directly inhibits Leydig/Testicular/Testicle Steroidogenesis [99] - by reducing the amount of these Receptors in the Body - with a Probiotic Supplement called 'LACTOBACILUS RHAMNOSUS' [100] - we can PERMANENTLY upregulate Testosterone production when used along with the Histamine Methods.
2. In the short-run, although limited to 3-Days of Use per every 3 weeks - because of the Compounds Toxicity - to Humans even...Thioperamide - a 'Research Chemical' and Novel Drug - can block HUMAN Histamine H4-Receptors AND H3-Receptors - resulting in Maximizing the amount of Gonadotropin-Secretions nearly IMMEDIATELY.
3. The degradative Enzyme Phosphodiesterase Type 8 - hinders Testosterone production by the Testicles  [101] [102] - by blocking it by using Butea Superba Extract [103] + Ginkgo Biloba Extract [104] + Caffeine (or Theobromine) DAILY [105] - we can Effective 'SUPER-STIMULATE' Testosterone secretion and Maximize our Hypothalamus and Pituitary Function.

***Additional Notes***

There is evidence that the Vital Aspects of Hypothalamic Function also rely on Potassium in the Cell [106] - this is also discussed on Hackstasis.com Forum in Great Detail [107]. Potassium stimulates the Androgen Axis & Androgen Receptor (AR) (Male-Hormone Receptor) [108] and promotes Nitric-Oxide Synthesis and Activity in the Brain & Body [109]. 

Testosterone's Vasodilating and Nitric-Oxide boosting activities [110] actually REQUIRE Potassium [111].

The Histamine H2-Receptor and "Specific" Facilitation of Both PERIPHERAL & CENTRAL Sexual-Responses as well as Testosterone-Secretion

1. Histamine, acting via Histamine H2-Receptors; the same ones that stimulate Stomach Acid - causes the Testicles to produce LARGE amounts of Testosterone [112] and Steroidogenic Proteins [113]. 
2. Histamine H2-Receptors CAUSE Penile Erection in Men (humans!) [114].
3. Histamine H2-Receptors also INCREASE Libido [115] [116] [117] - by raising the levels of a Second-Messenger known as "cyclic AMP" or "cAMP" [118]. Cyclic AMP (cAMP) stimulates Libido & Sexual Response [119] and Testosterone-Production [120] as well as Androgen-Receptor making/creation (by raising cAMP --> Protein Kinase A) [121] [122] [123]. See FREE Book/Study "Neural Control of Sexual Function in Men" for a more In-Depth Read.
4. Histamine H2-Receptors also stimulate OXYTOCIN release [119], which leads to increased ROMANTIC FEELINGS & Romantic Attachment [120], as well as Erection/Sexual Arousal [121] and Orgasm/Ejaculation [122]. Oxytocin also increases feelings of LUST [123] - and thus, is absolutely PRIMAL in Men for PASSION & "Romantic Drive" versus purely Animal-Like Sexual Drive.
5. Histamine H2-Receptors inhibit (reduce) GABA in the Hypothalamus [124] - leading to more Glutamate [125] & Dopamine-release [126] - causing Penile Erections [127] [128] [129] and sexual libido [130] through this Pathway, As-Well.

Ideas for STIMULATING the Histamine-H2-Receptor.

1. As noted in Our Article: Natural Histamine H2 Agonists & Medicines that Activate Histamine H2-Receptors - there is a Variety of both Natural & Pharmaceutical Methods one can USE to *specifically* activate the Histamine-H2-Receptors - thus SKY-ROCKETING Testosterone Production & Libido as well as General Sexual Function.
2. Black Pepper Extract (Piperine) can stimulate Histamine H2-Receptors [131] - I've noticed eating WHOLE Black Peppercorns actually Causes nearly IMMEDIATE Acid Reflux & increased Libido. Supplementally, you should use BOTH Liquid Black Peppercorn Extract + "Bioperine". Using them together GUARANTEES sufficient Histamine H2-Receptor Activation.
3. You can also simply Supplement with L-Histidine which is the DIRECT Precursor to Histamine and converts (turns into) into Histamine in the Human Brain [132].
4. Theoretically, one could use a drug called "Dimaprit" - which although technically ISN'T available to the General Public - if you CONVINCE a Research Drug (BioChemical) Facility to sell it to you, or you have a University Address - or KNOW SOMEONE with a Valid Medical License - you could have it also Synthesized. Dimaprit is a SPECIFIC Histamine H2-Direct Agonist - that is - it basically goes INTO the Body and directly "hops onto" or activates the Histamine H2-Receptors *ONLY* [133].
1. Because Histamine promotes Compulsive Sexual Behavior [134] - it wouldn't be surprising that for MOST - using these Methods may lead to Compulsive & Excessive Masturbation FRENZIES as well.

Histamine H3-Receptors - The "Negative" Control of Neuronal Nitric Oxide Synthase (nNOS) and the "Output" Regulator that CAUSES Stimulant Crash & Depression.

1. Histamine H3-Receptors promote Tranquility [135], Sleep [136], Tics/Motor Tics/Tourette's Symptoms [137] [138] [139] - and, they CAUSE The Dreaded "Stimulant Crash" [140]. 
2. Activities such as Outdoor Hiking, Exploration of New Countries, Cave-Diving & other "Novelty-Based Interests" are clearly CHARGED (made) by Histamine [141] [142] [143].
3. Rigorous & Intense Exercise stimulates Histamine Receptors and Histamine levels [144], even WALKING increases Histamine levels by stimulating Histidine-Decarboxylase (HDC) - thereby facilitating Histidine --> Histamine conversion in the Brain/Body [145].
4. Whereas, of course, Histamine H3-Receptors play an *OPPOSITE* (Negative) Role in Exploration & Human Motivations [146].

In/Tags: advances in the biochemical realm of neuroendocrine enhancement, biochemical sexual enhancement 2018, worlds strongest sex drug 2018, best libidogenic drug 2018, best libido supplement 2018