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Friday, November 28, 2014

Symptoms and Signs of Serotonin 5-HT1A Receptor OVER-ACTIVATION & Activity / Too Much 5-HT1A

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By no means are these symptoms ONLY caused by 5-HT1A activation, and there are indeed, many causes of too much 5-HT1A activation, this article should only be a reference point to compare a SET OF SYMPTOMS with your own - but one should not assume that this is the reason without corresponding bloodwork/urine screening; AT LEAST ON 5-H1AA ( a serotonin metabolite) - to determine if the autoreceptor inhibition of serotonin release is the issue. However, this does not mean that you can't have high serotonin levels and 5-ht1A activation, because it doesn't necessarily translate to peripheral or liver related degradation of serotonin - which is handled by monoamine oxidase and other enzymes.
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The symptoms of serotonin 5-HT1A overactivation would be summarized as follows.

  • ANTICIPATORY ANXIETY; e.g "can't wait for" behavior, impatient in lines, awaiting the arrival of goods causing anxiety, or anxiously awaiting paycheck. (part of why serotonin can cause anxiety)
  • Emotional dampening; bluntness,shallow faced, expressionless, indifferent. This is because of serotonin 5-hT1A's interactions with the opioidergic systems, as well inhibition of amygdala dopamine and glutamate activity which normally act to facilitate these emotions.
  • Low / Slow Sexual response, low libido, delayed ejaculation, erectile dysfunction, hypoactive sexual desire/arousal in women.
  • LONG-TERM MEMORY PROBLEMS, PROBLEMS WITH CONCENTRATION, ESPECIALLY IN ACTIVE MEMORY, AND MEMORY CONSOLIDATION TASKS.
  • PARADOXICAL AGGRESSION, NORMALLY THIS RECEPTOR IS ANTI AGGRESSIVE ITSELF, BUT....BECAUSE IT IS AN AUTORECEPTOR, IT MAY ACTUALLY INCREASE AGGRESSION BY LOWERING OTHER NEUROTRANSMITTERS THAT ACT TO INHIBIT IT.

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