Tuesday, December 9, 2014

List of Purchasable DRI's - Dopamine Reuptake Inhibitors - Both Pharma / Natural - Where to Get DRIs Online

Let me assure you, there is a point to dopamine reuptake inhibition - also known as DAT INHIBITION.

The benefits of doing this are many.

Increase short-term memory.
Alleviate depression.
Increase cognitive function, including active memory.
Increase creativity.
Increase libido.
Increase motivation.
BETTER QUALITY OF LIFE.

The first major , natural DOPAMINE REUPTAKE INHIBITOR IS....

"FLOWERING QUINCE EXTRACT"

http://www.ncbi.nlm.nih.gov/pubmed/18485464

Pharmacol Biochem Behav. 2008 Sep;90(3):363-71. doi: 10.1016/j.pbb.2008.03.014. Epub 2008 Mar 30.

Dopamine transporter inhibitory and antiparkinsonian effect of common flowering quince extract.

Zhao G1, Jiang ZH, Zheng XW, Zang SY, Guo LH.

Author information

Abstract

Common flowering quince (FQ) is the fruit of Chaenomeles speciosa (Sweet) Nakai. FQ-containing cocktails have been applied to the treatment of neuralgia, migraine, and depression in traditional Chinese medicine. The present study assessed whether FQ is effective in dopamine transporter (DAT) regulation and antiparkinsonism by utilizing in vitro and in vivo assays, respectively. FQ at concentrations of 1-1000 microg/ml concentration-dependently inhibited dopamine uptake by Chinese hamster ovary (CHO) cells stably expressing DAT (D8 cells) and by synaptosomes. FQ had a slight inhibitory action on norepinephrine uptake by CHO cells expressing the norepinephrine transporter and no inhibitory effect on gamma-aminobutyric acid (GABA) uptake by CHO cells expressing GABA transporter-1 or serotonin uptake by the serotonin transporter. A viability assay showed that FQ mitigated 1-methyl-4-phenylpyridinium-induced toxicity in D8 cells. Furthermore, in behavioral studies, FQ alleviated rotational behavior in 6-hydroxydopamine-treated rats and improved deficits in endurance performance in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Furthermore, immunohistochemistry revealed that FQ markedly reduced the loss of tyrosine hydroxylase-positive neurons in the substantia nigra in MPTP-treated mice. In summary, FQ is a selective, potent DAT inhibitor and has antiparkinsonian-like effects that are mediated possibly by DAT suppression. FQ has the potential to be further developed for Parkinson's disease treatment.

PMID:: 18485464; [PubMed - indexed for MEDLINE]

THE SECOND NATURAL - HERBAL - DOPAMINE REUPTAKE INHIBITOR IS....

!CATUABA EXTRACT!

http://www.ncbi.nlm.nih.gov/pubmed/15991001

2005 Oct;182(1):45-53. Epub 2005 Sep 29.

Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms.

Campos MM1, Fernandes ES, Ferreira J, Santos AR, Calixto JB.

Author information

Abstract

RATIONALE:

Currently available therapy for depression treatment is often associated with several undesirable side effects, and it is effective only in a certain portion of the population. Therefore, the identification of alternative therapeutic tools for the treatment of depression is still needed.

OBJECTIVE:

The present study analyzed the possible antidepressant-like effects of the Brazilian medicinal plant, Trichilia catigua, in rodents. Attempts were also made to investigate some of the possible mechanisms implicated in its actions.

METHODS:

The antidepressant-like effects of T. catigua extract were assessed in two species of rodents (mice and rats) by means of in vivo (forced swimming test) and in vitro (monoamine reuptake and release in synaptosomal preparations) approaches.

RESULTS:

Acute oral treatment with the extract of T. catigua produced antidepressant-like effects in the forced swimming model in both mice and rats. Anti-immobility actions of T. catigua extract in mice were significantly reversed by haloperidol or by chlorpromazine, but not by pimozide, ketanserin, spiroxatrine or p-chlorophenylalanine. In vitro, T. catigua extract concentration-dependently inhibited the uptake and increased the release of serotonin, and especially of dopamine, from rat brain synaptosomal preparations.

CONCLUSIONS:

The present study provides convincing evidence for a dopamine-mediated antidepressant-like effect of the active principle(s) present in the hydroalcoholic extract of T. catigua in mice and rats when in vivo and in vitro strategies were employed. Therefore, a standardized T. catigua extract or its purified constituents could be of potential interest for the treatment of depressive disorders.