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Thursday, April 7, 2016

Symptoms of High / Excess GABA Levels (How Can You Tell If Your GABA Level Is Too High?)

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Some of the Symptoms of high / too much GABA will very closely mirror low Glutamate symptoms | 1 |. Most of it will pertain to mental health and cognitive issues |2| |3| as evidenced by the effects of benzodiazepines on mentality |4| and alike to a moderate degree of intoxication |5|. Because GABA opposes cholinergic `(of acetylcholine) |6|, glutamatergic (of glutamate) |7| and dopaminergic/noradrenergic (of dopamine and noradrenaline) |8| |9| neurotransmission, excess GABA will also closely mirror deficiencies of each of those neurotransmitters.



The GABAergic `controls`` are the brakes on several cognition promoting neurotransmitters, however, GABA plays beneficial roles in mood and memory as well |10|, particularly in releasing growth hormone |11|, and in promoting nerve growth in some instances |12|. It also reduces cortisol secretion/release, which can have important anti-stress effects |13| |14|.

Despite this, having excessive GABA will negatively impact a number of cognitive functions and will especially influence nitric-oxide release ....

SO, WHAT Are The Signs of `Too High`` GABA?? Excess GABA Symptoms include...

  • Impaired Short-Term Memory |!|
  • Impaired Coordination |!|
  • Impaired Working Memory |!|
  • Impaired Spatial Memory |!|...
  • Low Motivation |!|
  • Disinhibition |!|
  • Irritable Dysphoria |!|
  • Apathy |!|
  • Delirium |!|
  • Odd Behavior |!|...
  • No / Little Restraint on Own Words |!|
  • Excessive Dependence on Stimulants |!|
  • Little Capacity for Emotional Connections |!|
  • Intolerance to Alcohol, or Strong Sensitivity to Alcohol and Other Sedatives |!|
  • Dilated Pupils |!|
  • Aggressive Behavior |.......|
  • Low Libido / Low Sex Drive / Absent Sex Drive / Absent Libido |!| 


IN BLOOD WORK / ENDOCRINE READ-UPS

  1. Low ACTH & Cortisol in Blood. |!|
  2. Secondary Hypogonadism if the GABA excess is genetic, and severe |!|
  3. Significant norepinephrine deficiency in blood work, and low whole blood glutamic acid levels |!| |!``!|.

SUGGESTIONS TO LOWER A HIGH/EXCESS GABA LEVEL
  1. Supplement with L-Histidine, which converts into histamine, which is a neurotransmitter that reduces excessive GABA. |!| |!`!|
  2. Supplement with Ginkgo Biloba Extract, which can antagonize moderately, the GABA-A Receptor |!| |/!!\|.
  3. EXERCISE!! Exercize may reduce excessive inhibitory neurotransmission by temporarily increasing noradrenaline/sympathetic nervous transmission, so do it often, for at least 30 mins to an hour! You'll feel better, Trust me!
** SUPPORTING REFERENCES **

ROLE OF GABA IN MEMORY AND ANXIETY - DEPRESSION AND ANXIETY 4:100–110 (1996/1997)

The Role of
Benzodiazepines
in the Treatment of
Posttraumatic Stress
Disorder (PTSD)

GABA & Memory - Bodybuilding.com Discussion

Prim Care Companion J Clin Psychiatry. 2005; 7(1): 23–32.
PMCID: PMC1076447
Benzodiazepines: Revisiting Clinical Issues in Treating Anxiety Disorders

Immunopharmacol Immunotoxicol. 1998 May;20(2):199-209.

Stress, neuropsychiatric disorders and immunological effects exerted by benzodiazepines.

Drugs. 1985 Jun;29(6):570-81.

Adverse neuropsychiatric effects of anticonvulsant drugs.




Brain glutamate deficiency in amyotrophic lateral sclerosis
Thomas L. Perry, MD, Shirley Hansen, BA and Karen Jones, BSc

Sleep. 2008 Mar 1; 31(3): 342–347.
PMCID: PMC2276749

Increased GABA Levels in Medial Prefrontal Cortex of Young Adults with Narcolepsy


Dialogues Clin Neurosci. 2006 Dec; 8(4): 383–395.
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Sean M. Smith, PhD
Sean M. Smith, Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, Calif, USA ;
Wylie W. Vale, PhD*
Wylie W. Vale, Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, Calif, USA ;
Author information ► Copyright and License information ►

Michael W. King, PhD: The BioChemistry of Neurotransmitters and Nerve Transmission : GABA

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