...
Some of the Symptoms of high / too much GABA will very closely mirror low Glutamate symptoms | 1 |. Most of it will pertain to mental health and cognitive issues |2| |3| as evidenced by the effects of benzodiazepines on mentality |4| and alike to a moderate degree of intoxication |5|. Because GABA opposes cholinergic `(of acetylcholine) |6|, glutamatergic (of glutamate) |7| and dopaminergic/noradrenergic (of dopamine and noradrenaline) |8| |9| neurotransmission, excess GABA will also closely mirror deficiencies of each of those neurotransmitters.
The GABAergic `controls`` are the brakes on several cognition promoting neurotransmitters, however, GABA plays beneficial roles in mood and memory as well |10|, particularly in releasing growth hormone |11|, and in promoting nerve growth in some instances |12|. It also reduces cortisol secretion/release, which can have important anti-stress effects |13| |14|.
Despite this, having excessive GABA will negatively impact a number of cognitive functions and will especially influence nitric-oxide release ....
SO, WHAT Are The Signs of `Too High`` GABA?? Excess GABA Symptoms include...
ROLE OF GABA IN MEMORY AND ANXIETY - DEPRESSION AND ANXIETY 4:100–110 (1996/1997)
The Role of
Benzodiazepines
in the Treatment of
Posttraumatic Stress
Disorder (PTSD)
GABA & Memory - Bodybuilding.com Discussion
Prim Care Companion J Clin Psychiatry. 2005; 7(1): 23–32.
PMCID: PMC1076447
Benzodiazepines: Revisiting Clinical Issues in Treating Anxiety Disorders
Immunopharmacol Immunotoxicol. 1998 May;20(2):199-209.
Stress, neuropsychiatric disorders and immunological effects exerted by benzodiazepines.
Drugs. 1985 Jun;29(6):570-81.
Adverse neuropsychiatric effects of anticonvulsant drugs.
Brain glutamate deficiency in amyotrophic lateral sclerosis
Thomas L. Perry, MD, Shirley Hansen, BA and Karen Jones, BSc
Sleep. 2008 Mar 1; 31(3): 342–347.
PMCID: PMC2276749
Increased GABA Levels in Medial Prefrontal Cortex of Young Adults with Narcolepsy
Dialogues Clin Neurosci. 2006 Dec; 8(4): 383–395.
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Sean M. Smith, PhD
Sean M. Smith, Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, Calif, USA ;
Wylie W. Vale, PhD*
Wylie W. Vale, Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, Calif, USA ;
Author information ► Copyright and License information ►
Michael W. King, PhD: The BioChemistry of Neurotransmitters and Nerve Transmission : GABA
Some of the Symptoms of high / too much GABA will very closely mirror low Glutamate symptoms | 1 |. Most of it will pertain to mental health and cognitive issues |2| |3| as evidenced by the effects of benzodiazepines on mentality |4| and alike to a moderate degree of intoxication |5|. Because GABA opposes cholinergic `(of acetylcholine) |6|, glutamatergic (of glutamate) |7| and dopaminergic/noradrenergic (of dopamine and noradrenaline) |8| |9| neurotransmission, excess GABA will also closely mirror deficiencies of each of those neurotransmitters.
The GABAergic `controls`` are the brakes on several cognition promoting neurotransmitters, however, GABA plays beneficial roles in mood and memory as well |10|, particularly in releasing growth hormone |11|, and in promoting nerve growth in some instances |12|. It also reduces cortisol secretion/release, which can have important anti-stress effects |13| |14|.
Despite this, having excessive GABA will negatively impact a number of cognitive functions and will especially influence nitric-oxide release ....
SO, WHAT Are The Signs of `Too High`` GABA?? Excess GABA Symptoms include...
- Impaired Short-Term Memory |!|
- Impaired Coordination |!|
- Impaired Working Memory |!|
- Impaired Spatial Memory |!|...
- Low Motivation |!|
- Disinhibition |!|
- Irritable Dysphoria |!|
- Apathy |!|
- Delirium |!|
- Odd Behavior |!|...
- No / Little Restraint on Own Words |!|
- Excessive Dependence on Stimulants |!|
- Little Capacity for Emotional Connections |!|
- Intolerance to Alcohol, or Strong Sensitivity to Alcohol and Other Sedatives |!|
- Dilated Pupils |!|
- Aggressive Behavior |.......|
- Low Libido / Low Sex Drive / Absent Sex Drive / Absent Libido |!|
IN BLOOD WORK / ENDOCRINE READ-UPS
- Low ACTH & Cortisol in Blood. |!|
- Secondary Hypogonadism if the GABA excess is genetic, and severe |!|
- Significant norepinephrine deficiency in blood work, and low whole blood glutamic acid levels |!| |!``!|.
SUGGESTIONS TO LOWER A HIGH/EXCESS GABA LEVEL
- Supplement with L-Histidine, which converts into histamine, which is a neurotransmitter that reduces excessive GABA. |!| |!`!|
- Supplement with Ginkgo Biloba Extract, which can antagonize moderately, the GABA-A Receptor |!| |/!!\|.
- EXERCISE!! Exercize may reduce excessive inhibitory neurotransmission by temporarily increasing noradrenaline/sympathetic nervous transmission, so do it often, for at least 30 mins to an hour! You'll feel better, Trust me!
** SUPPORTING REFERENCES **
ROLE OF GABA IN MEMORY AND ANXIETY - DEPRESSION AND ANXIETY 4:100–110 (1996/1997)
The Role of
Benzodiazepines
in the Treatment of
Posttraumatic Stress
Disorder (PTSD)
GABA & Memory - Bodybuilding.com Discussion
Prim Care Companion J Clin Psychiatry. 2005; 7(1): 23–32.
PMCID: PMC1076447
Benzodiazepines: Revisiting Clinical Issues in Treating Anxiety Disorders
Immunopharmacol Immunotoxicol. 1998 May;20(2):199-209.
Stress, neuropsychiatric disorders and immunological effects exerted by benzodiazepines.
Drugs. 1985 Jun;29(6):570-81.
Adverse neuropsychiatric effects of anticonvulsant drugs.
Thomas L. Perry, MD, Shirley Hansen, BA and Karen Jones, BSc
Sleep. 2008 Mar 1; 31(3): 342–347.
PMCID: PMC2276749
Increased GABA Levels in Medial Prefrontal Cortex of Young Adults with Narcolepsy
Dialogues Clin Neurosci. 2006 Dec; 8(4): 383–395.
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Sean M. Smith, PhD
Sean M. Smith, Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, Calif, USA ;
Wylie W. Vale, PhD*
Wylie W. Vale, Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, Calif, USA ;
Author information ► Copyright and License information ►
Michael W. King, PhD: The BioChemistry of Neurotransmitters and Nerve Transmission : GABA
Very informative. After having a bad reaction to gabapentin- bloody stools, having almost no effect from xanax, a more wakeful existence when eating high histamine foods, low libido, and many other parallels with what is discussed here, I'm eager to test drive this theory.
ReplyDeleteOne of the other "signs" of high GABA can also be 'Aggressive' reactions to Benzodiazepines. My cousin recently got tested and his consistently high *serum* (blood) GABA levels explains his RAGE issues as a Child when briefly put on Xanax, Klonopine etc.
Delete...It would thus appear that (and according to Study), the ELEVATED GABA can most prominently lead to RAGE, particularly dysphoric, irritable Rage, in those where other symptoms are not apparent.
~Jay
You will write about low gaba levels symptoms?
ReplyDelete