Ever since their initial synthesis (creation) by a Romanian chemist named Lazar Edeleanu [1] - Amphetamines have both fascinated [2] and inspired the World [3]. Hitler was famous for using Amphetamines to power his Career and rulership [4], and he had most of his Nazi-Pilots/personnel using it for better efficiency and awareness [5]. Amphetamines have been used by Military Personnel in prior World Wars [6] and are still used, today, in the US Military [7] and many other countries military [8]. The Allied Forces (Britain & America) also used Amphetamine during World War 2; back then it was known as "Benzedrine" [9] [10] [11].
Amphetamines have an acute (immediate/short-term) Memory & Focus enhancing effect [12] [13] [14] - and the effects often occur along with Euphoria AKA a "high" or "buzz" [15]. College Kids pop Adderall and other amphetamine derivatives in the hopes of being more adequately prepared & efficient on Tests/Exams and other major study sessions [16].
By the races, Amphetamine use is more common in White people [17] and that is, in part, because White European or American Men & Women tend to have a better response to Amphetamines due to genes passed down (mU-opioid-gene) [18]. Asians also seem to like their Amphetamines [19], on occasion - this may be due to "High-Intelligence Genes" that are present in Asian Men & Women [20]. They may find they are better able to USE their Intelligence in real-world scenarios with the help of Amphetamines; particularly Dexedrine.
Now, some are perfectly OK with taking the drugs and just letting the normal Rush and Crash process to occur...but for those who want the MOST out of their Stimulant Drug - it may be a good idea to look into ways of EXTENDING or ENHANCING the effects of Amphetamines...but in order to do that we MUST first have a basic understanding of how Amphetamines work in the Brain!
Neuroscience. 2015 Sep 24;304:90-100. doi: 10.1016/j.neuroscience.2015.07.048. Epub 2015 Jul 23.
Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator.
Cui X1, Pertile R1, Liu P1, Eyles DW2.
Adderall Tolerance: Causes & How To Prevent It.
(MENTAL HEALTH DAILY)
J Neurochem. 1985 Dec;45(6):1842-9.
Regulation of anterior pituitary D2 dopamine receptors by magnesium and sodium ions.
Watanabe M, George SR, Seeman P.
In/Tags: supplements to extend the effects of adderall 2019, supplements to extend the effects of amphetamine 2019, vitamins to enhance amphetamines effects 2019, how to enhance amphetamines effects 2019
Amphetamines have an acute (immediate/short-term) Memory & Focus enhancing effect [12] [13] [14] - and the effects often occur along with Euphoria AKA a "high" or "buzz" [15]. College Kids pop Adderall and other amphetamine derivatives in the hopes of being more adequately prepared & efficient on Tests/Exams and other major study sessions [16].
By the races, Amphetamine use is more common in White people [17] and that is, in part, because White European or American Men & Women tend to have a better response to Amphetamines due to genes passed down (mU-opioid-gene) [18]. Asians also seem to like their Amphetamines [19], on occasion - this may be due to "High-Intelligence Genes" that are present in Asian Men & Women [20]. They may find they are better able to USE their Intelligence in real-world scenarios with the help of Amphetamines; particularly Dexedrine.
Now, some are perfectly OK with taking the drugs and just letting the normal Rush and Crash process to occur...but for those who want the MOST out of their Stimulant Drug - it may be a good idea to look into ways of EXTENDING or ENHANCING the effects of Amphetamines...but in order to do that we MUST first have a basic understanding of how Amphetamines work in the Brain!
AMPHETAMINES - HOW THEY WORK!
(SIMPLE EXPLANATION!)
- Amphetamines act as an "agonist" or something that ACTIVATES a certain neural pathway - in the Body there are things called "Receptors" which are like a locked door that the neuron (neurotransmitter) in question must "unlock" to pass through and open the door to the effects - so that they have both the ability and road to exert such effects. Specifically, Amphetamines act as a TAAR1 agonist [21] [22] opening the 'doorway' to the Trace-Amine Associated Receptor 1 (TAAR1).
- By activating this pathway - Amphetamines SKY-ROCKET the level of a 'messenger molecule' in the Brain/Body known as "cAMP" or cyclic adenosine monophosphate [22] [23].
- This MASSIVE boost in cAMP causes other proteins to increase their production (Protein Kinases) which then leads to the effective 'TRAPPING' of neurotransmitters in the Brain - so that they are more active and fire more consistently [24] [25] [26].
- Specifically, the "transporters" which are things in the body responsible for REMOVING neurotransmitters (nerve cells that send signals) - these transporters are "inhibited" or blocked/REVERSED. So that they force the neurotransmitter back into the Brain versus being able to exit [27].
- Amphetamines also SEMI-PERMANENTLY reduce (drop the levels of) a protein in the Brain called the "Norepinephrine Transporter" or NET [28].
So...knowing all of this, HOW do we EXTEND and ENHANCE the effects of Amphetamines???
Well ANYTHING that works in the 'same direction' will do this. However - we have to take into consideration that SAFE additions are necessary...and also other things like.
- The FACT that Dopamine-receptors can become "desensitized" or NUMB by Amphetamine - causing NOT ONLY the drug itself not to work well - but ALSO - can cause the Brain's natural dopamine to not work well...thus leaving one feeling Depressed, Hopeless, and Emotionally Numb [29].
- The FACT that Magnesium can cause the Dopamine receptors to become sensitive again [30]. Buy STRAWBERRY Liquid Magnesium Here.
- The FACT that Amphetamines have 'other' immediate & long-term effects like REDUCTION of Dopamine-autoreceptor function (which regulates Dopamine activity) [31].
- The FACT that Amphetamines "desensitize" or numb-out the K-opioid-receptor [32].
- The FACT that Amphetamines cause changes in certain Regions in the Brain versus others (striatum for example) [33] [34] [35].
TO ENHANCE/EXTEND the Effects of ADDERALL/AMPHETAMINE
[FIVE Supplements that Enhance and Extend Amphetamine Effects]
- Forskolin [reference]: Forskolin activates cyclic-AMP; the same messenger that Amphetamines activates and works through - in my own experiments, Forskolin both EXTENDS and ENHANCES the Euphoria or "rush" of Amphetamines. Forskolin also increases the number of Dopamine-D2-receptor sites in the human brain [36] - leading to more effects per stimulation from each dose [37].
- Vitamin C (Ascorbic Acid) [reference]: HIGH-DOSE Vitamin C, namely combining an Ester-C supplement with the EMERGEN-C brand Vitamin C (found in Grocery Stores, 7-11 etc) - this IMPROVES the focus produced by Adderall, and others have found the same thing [38]. Dump TWO packets of Emergen-C in water and take it with FOUR of these Ester-C pills. Vitamin C or Ascorbic Acid ALSO enhances Amphetamines/Stimulants effects by causing more production of NOREPINEPHRINE - a key neurotransmitter in Amphetamines effects. Vitamin C does this by stimulating an 'enzyme' known as DBH; Dopamine-beta-hydroxylase [39] [40] [41].
- Copper [reference]: Copper also stimulates norepinephrine and Adrenaline production; leading to increased 'stimulation' and environmental/social related Effects of Amphetamine.
- Life Extension "DOPA-MIND" [reference] [study]: Dopa-Mind contains Wild Green Oat Extract (WGOE) - it is patented as "NEURAVENA" and its effects include STOPPING the breakdown/removal of Dopamine by blocking a target known as MAO-B. In ALL research studies - Amphetamines effects are ENHANCED when MAO-B is blocked in the Brain [42]. Thus, you could (in theory) use a Pharmaceutical MAO-B inhibitor like RASAGILINE - however, this would be more risky and possibly create more Amphetamine/Adderall related side-effects!
- Mucuna Pruriens L-Dopa Extract [reference]: L-Dopa or levodopa TURNS INTO Dopamine in the Brain - since Amphetamine "uses up" the Dopamine stored in the Brain/Body - you need to give your Body more of it so that amphetamine has more to move around [STUDY]. This strategy has worked for THOUSANDS [43]...and is raved about on LongeCity; a popular NeuroScience & Longevity forum!
BENEFITS OF ADDERALL VERSUS STRAIGHT D-AMPHETAMINE, DEXEDRINE OR VYVANSE
- Adderall's "combined" form of Amphetamine; four different forms of Amphetamine - is SUPERIOR in increasing the Dopamine level in the Brain versus regular D-Amphetamine (Dexedrine) [44].
- Thus, Adderall has a longer duration and more intense Positive Effects [45]. This has also been MY EXPERIENCE.
- Adderall tends to be easier to obtain - is covered by Medicaid and other insurances...is fairly cheap at the Pharmacy. However, you can *also* buy them on the Dark Net (darkweb) - specifically on a 'Market' called DREAM MARKET. Dream Market is located on the 'dark web' which is a "secret" part of the Internet that you can ONLY access when using the TOR-Anonymous Browser...these 'secret' URL's are also known as ONIONS - as they end in .ONION!
- After downloading TOR-browser on an Android Phone, iPhone or on a Windows or MAC PC - you can shoot over to THIS-URL: http://t5kqoucj5kbboheh.onion/?ai=1675
- However, to avoid potential legal repercussions - I RECOMMEND obtaining a Prescription from a Psychiatrist! You may have to go to a short INPATIENT Hospital stay to have a test called a "NeuroPsych" conducted...also means neuropsychological test/testing. If the RESULTS of the Observation show that you have substantial ATTENTION issues (easily distracted, can't maintain focus on Questions or forms, takes forever to get one task done), then you can ASK your Psychiatrist to "consider Adderall". One way to MAKE SURE he prescribes THAT pill is by falsely reporting an Allergy to the other options via your General Physician's office. Most GP's won't "investigate" the claim and will take your word for it. So BE SURE to let the Regular General Doctor KNOW that you "had a bad allergic reaction to Concerta/Ritalin". This leaves pretty much ONLY the Amphetamine drugs on the table for the Doctor to Prescribe!
***OTHER WAYS TO EXTEND ADDERALL'S EFFECTS 2019***
- Vitamin D stimulates the enzyme that tells the Brain to actually "make Dopamine"; the enzyme is known as TYROSINE HYDROXYLASE [46]. In studies, ANYTHING that increases Tyrosine Hydroxylase (TH) INTENSIFIES Amphetamines effects [47]. There's a clear connection between Vitamin D (D3) levels and Depression & Nervous Behavior!
- Although Amphetamine ITSELF stimulates Dopamine-production via increasing Tyrosine Hydroxylase [48] - these effects are thought to be somewhat limited (lesser) than the other mechanisms.
- OTHER POSSIBILITIES: I have not (personally) experimented with these, but my guess would be that if you DEPLETE Serotonin - you may "enhance" the Dopamine that is released through Amphetamine/Adderall. So the drug FENCLONINE (P-chlorophenylalanine) may INTENSIFY Amphetamines effects! It may also intensify Dextroamphetamines effects, specifically.
- BCAA's or Branched Chained Amino Acids ALSO deplete Serotonin in the Human Brain [49] - many anecdotal reports state that BCAA + L-Dopa usage along with AMPHETAMINE is an unmatchable Combination! In that the effects were in one case "so enhanced I felt like God 24/7".
***OTHER INTERESTING LINKS***
BY: Nicolas Rasmussen, PhD, MPhil, MPH
J Biomed Sci. 2016; 23: 21.
Published online 2016 Feb 3. doi: 10.1186/s12929-016-0239-2
PMCID: PMC4738766
PMID: 26841904
Christina H. Liu, Jiaqian Ren, and Philip K. Liu [corresponding author]
W. Feldberg and W. J. Lang
Rambam Maimonides Med J. 2010 Jul; 1(1): e0003.
Published online 2010 Jul 2. doi: 10.5041/RMMJ.10003
PMCID: PMC3721659
PMID: 23908775
John P.M. Finberg, Ph.D.*
Neuroscience. 2015 Sep 24;304:90-100. doi: 10.1016/j.neuroscience.2015.07.048. Epub 2015 Jul 23.
Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator.
Cui X1, Pertile R1, Liu P1, Eyles DW2.
Adderall Tolerance: Causes & How To Prevent It.
(MENTAL HEALTH DAILY)
J Neurochem. 1985 Dec;45(6):1842-9.
Regulation of anterior pituitary D2 dopamine receptors by magnesium and sodium ions.
Watanabe M, George SR, Seeman P.
In/Tags: supplements to extend the effects of adderall 2019, supplements to extend the effects of amphetamine 2019, vitamins to enhance amphetamines effects 2019, how to enhance amphetamines effects 2019
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