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Friday, June 12, 2015

How to : Treat Anti-Psychotic Induced Weight Gain (Reverse / Prevent AntiPsychotic Weight Gain)

Anti-Psychotic drug induced weight gain is a very common occurrence, especially in those taking Zyprexa ( OLANZAPINE ) and Risperdal ( RISPERIDONE ) (1) (2) ...

Anti-histamine effects are a huge contributing factor in anti-psychotic induced weight gain(3) (4) (5), and the anti-serotonin property (specifically the 2C antagonist effects) also play a huge role(5). Belviq ( LORCASERIN ) works as a direct opposite to this effect, acting instead as a serotonin 2C agonist(6). However, during anti-psychotic treatment, the effects of serotonin agonists will be blocked or minimized in most cases. 

Can Belviq help anti-psychotic induced weight gain?

Most likely, No.

What to use instead?

Use a histamine H3 antagonist like betahistine (7) or KUTAJ (8) (9) extract to counter weight gain and some of the sedation of antipsychotic drugs.

Betahistine can be purchased here, it is legal and not a controlled substance anywhere. >

Hollarhena (KUTAJ) can be purchased below. 


Additionally, ginkgo biloba can be used to minimize prolactin increases (10) (11) which may be caused by anti-psychotic drugs which (prolactin) may also lead to weight gain, ginkgo is also very synergistic with KUTAJ and betahistine(12)(13)(14).


ANDRACTIM DHT Gel (shown below) is a gel you can apply to your chest area to help prevent & reverse anti-psychotic induced gynecomastia and estrogen and prolactin related issues.

Click the image below to buy DHT Gel.

click here now


  1. So betahistine helps lower prolactin or what? From your blog I found that H1 upregulation increases prolactin release. But "Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function. " says H3 antagonism makes positive changes regarding D1(motivation) and D2. You mentioned D2 has bad sides. But some studies say upregulating D2 helps with internet|port addiction and pair bonding. Cabergoline agonizes it.
    Also I found Ginkgo Biloba enhances catalepsy. Is that due to D2 and D1 reducing. So how really GB is able to reduce prolactin|increase dopamine?
    Also may I ask additional question here? If serotonin is too high through desensitizing 5ht(1a) autoreceptor how it can reduce oxytocin from high histamine?

    1. Technically, betahistine and other H3R antagonists may indirectly enhance hormone function. However, because H3R's are lesser so in the hypothalamus than say the , the H1's - you are more likely looking at an enhancement in gonadotropin and central nitric oxide prodution. Prefrontal cortex contains a lot of H3 AND D1 - so the enhancement in dopaminergic function regarding that interaction is likely more so in the PFC and striatum. Thus enhancing motivation and attentiveness Upregulating D2 would help release oxytocin so it could help with pair bonding; the more dopamine; typically it's easier to engage in love and bonding. ... but it also depends on how much serotonin, glutamate , histamine and other factors. Ginkgo doesn't antagonize dopamine at all - but it does act as both a 5-HT1A agonist and a GABA-A antagonist; the latter property contributing to catalepsy and anxiogenic properties. If serotonin is high - it will reduce oxytocin by interacting with corticosteroid systems and inhibiting dopamine and glutamate by 5-HT2C, 5-HT6, 5-HT7


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