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Wednesday, April 6, 2016

Symptoms of High Glutamate Levels in the Brain / Body (How to Tell If You Have High Glutamate Levels)

This article probably should have been done before the low Glutamate article, as it is a far more common condition, or, state-of-mind, to have elevated glutamate than low levels. However, despite elevated glutamate having been written about a lot more frequently, I am tired of seeing the same bullshit being posted, without proper references, or with very generalized (and often wrongly placed) citations, there are immense distortions out there.

I am here to clear away those aggravations.

The negative effects of excessive glutamate are no surprise, especially given that high levels of activation of a SINGLE-glutamate receptor such as the kainate-receptor, itself, without touching any of the other receptors, can result in Cell Toxicity [1] [2].

So an abnormal buildup of glutamate all-over the place would most certainly result in massive toxicity. However, most people don't acquire the amount of glutamate-toxicity that would result in significant cell death, at least not at a young age, there is normally some degree of natural protection against it by the brain's 'other-forces', alpha-waves, and other neurotransmitters that youthful individuals seem to have more of (i.e noradrenaline/dopamine, serotonin etc). Even without, or with less of those factors, normally, there are anti-inflammatory mediators that reduce glutamate toxicity, heck, even histamine (not antihistamines, but rather, histamine, the chemical that benadryl and crap like that block), has protective effects against glutamate [3], of course, it has to be in the 'right' proportion/s.

Well here we go, the symptoms of glutamate-excess are...!


  • Insomnia [4] [5]
  • Social Anxiety [6]
  • Emotional Lability [7] (being over-emotional, crying at movies, music , smells etc)
  • Agitation [8] (often impulsive aggression, or easy to provoke, and increased sensitivity to sensory input due to enhanced glutamate often leads to increased reactions, i.e, one with a lot of glutamate may get angry when pinched, coughed around, or when property is touched by the 'wrong' person)
  • Racing Thoughts [9] (though this can be caused by other factors, like low noradrenaline, high noradrenaline, low dopamine, high dopamine, racing thoughts due to high glutamate is generally related to emotional scenarios, often not positive, often about or anticipating future events, often related to work).
  • Hedonic Attachment [10] - High glutamate individuals are typically prone to exhibitionism, overt display of emotions and desires, and especially, an attraction to gaining, holding, or becoming one with anything that produces a 'good feeling', thus, you will hear a high level of report that the person with high glutamate 'wants to fall in love' or wants to try LSD', with a higher probability of the former, because high glutamate individuals are 'into' life in general, they produce fairly large amounts of oxytocin, and though are sometimes socially aversive, they also can be quite the opposite, all relating back to their need for attachment, and generally 'enjoying life'.
  • Stress [11] [12] - Despite the above, high glutamate levels often lead to stress-states when things don't go as planned, having tons of glutamate allows one to overthink things, and for all emotions : including Anger or Sadness, to simmer, and many high glutamate individuals believe they can internalize their emotions, and often attempt to suppress them, until they explode, and feel the great need to unleash their emotions onto someone or something, but nevertheless, elevated/high glutamate individuals are thus prone to these scenarios, and particularly devastated during loss of a loved one, or loss of a relationship etc. This does not however, mean, that high glutamate individuals are those types who would generally become malicious, or take their feelings out on 'just anyone', in fact, they have a tendency to vent towards a friend, or utilize some other resources to get their feelings out.
  • Shopping Spree's : [13] [14] : High glutamate individuals often feel an unusually intense attraction to novelty, and looking at objects/items through glass windows in a mall, and generally, cling to the idea of 'shopping' for new stuff, of course, what they shop for will depend on the person and their experiences, but high glutamate individuals are generally desire based shoppers versus need-based shoppers, that is, they shop for what suits their tastes, or visual appeal, or imagine what may provide them 'something to do', as opposed to shopping for 'traditional' reasons. So one with high glutamate is more likely to shop then, 'in-the-moment', than 'for stock and supply' or other, future need based items. 
  • Other Addictions [15] : People with elevated glutamate are biologically more prone to all kinds of addictions, and the reinforcing Effects of various drugs.
  • Mania [16] : Because high glutamate persons are characteristically opposite of GABA-dominant personalities, they are often Manic, and exhibit multiple behavioral components of several, past or present, BiPolar diagnosis.

  PHYSICAL SYMPTOMS OF HIGH GLUTAMATE IN MEN & WOMEN
  • FREQUENT HEADACHES/Migraines [15].
  • Frequent Nausea [16]
  • Fast Heart Rate, or Low Heart Rate, higher chance of being high (tachycardia, or higher than normal at least) [17]
  • Prone to high blood pressure when approaching early 30's [18].
  • Inner Tension / Restlessness [19]
  • Restless Legs Syndrome [20] (moving/jerking legs around at night due to restlessness, and strange surging sensations in legs that provoke one to move them, exercise them, cross them, curl them etc)
SUGGESTIONS TO SAFELY DECREASE A HIGH GLUTAMATE LEVEL WITHOUT AFFECTING COGNITION


  1. Supplement with Phenibut; it's an antianxiety agent that activates the GABA-system, this leads to a subtle opposition of glutamate-transmission in the nervous system [21] [22]. I recommend Ceretropic-brand. It also improves memory.
  2. Supplement with a particular rhodiola Rosea extract (Golden Root), it helps protect brain cells from excessive glutamate activity [23], it also improves endurance, strength, oxygen utilization and helps the body with coping to stress [24].
  3. Finally, eat more fruits and in general, Vitamin A & C containing foods (especially carrots, and sulfur containing foods like cabbage and onions, onions and garlic help the best to reduce excitotoxicity & Glutamate [25] [26] [27].
[ You could also try L-THEANINE, an amino acid instead of Phenibut, it reduces Anxiety and Stress manfestation as well ! ]

**OTHER SOURCES**
http://www.ncbi.nlm.nih.gov/pubmed/16400245
http://www.ncbi.nlm.nih.gov/pubmed/15575797
http://www.ncbi.nlm.nih.gov/pubmed/23624560
http://www.cortjohnson.org/blog/2013/02/15/glutamate-one-more-piece-in-the-chronic-fatigue-syndrome-mecfs-puzzle-the-neuroinflammatory-series-pt-ii/

25 comments:


  1. You need to be a part of a contest for one of the best websites on the internet.
    SAP GTS Training In Hyderabad

    ReplyDelete
  2. Except theanine converts to glutamate......

    ReplyDelete
    Replies
    1. Theanine converts to GABA. Glutamate and GABA can convert into one another depending on the body's needs and functionality. Theanine and supplementing GABA can be great, but if you are worried about any of your GABA converting back to glutamate the best thing to do is support your GAD function. GAD is an enzyme that converts glutamate and its sources to GABA - and the action CANNOT be reversed. (Vitamin B6 and a little bit of zinc can help produce GAD). Or you can take something which inhibits glutamate from converting to GABA - Lemon balm has been shown to do this.

      Delete
    2. Theanine activates GABA-neurons, it doesn't "convert" into GABA itself. It simply modulates the GABA activity.
      --> https://www.ncbi.nlm.nih.gov/pubmed/17182482

      Delete
  3. Except theanine converts to glutamate......

    ReplyDelete
  4. Nmda antagonists, memantine, also magnesium specifically mangnesium turate (if deficient) just be aware of dp/dr symptoms in excess antagonism but this wouls likely only occure with excess dxm and drugs like that. Longecity and reddit have some interesting threads.

    ReplyDelete
  5. Nmda antagonists, memantine, also magnesium specifically mangnesium turate (if deficient) just be aware of dp/dr symptoms in excess antagonism but this wouls likely only occure with excess dxm and drugs like that. Longecity and reddit have some interesting threads.

    ReplyDelete
  6. The symptoms most people goes thru those things I would call naturally what is the one thing that stands out above any other symptom I hope this isn't a silly question but it's important for me to know and is there any test doctors can do without going in to the brain itself. Please be sure of your answers like I said it's important. Thank you

    ReplyDelete
    Replies
    1. The only way to know for sure is to have a Doctor do a blood/urine test for plasma/urine Glutamate & Glutamic acid levels.

      Delete
  7. do you have an email i can ask you a few glutamate questions ? I have some very big concerns about glutamate ,thanks!

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  8. Replies
    1. Yes, it can help; by antagonizing N-Type Calcium Channels; thus lowering Glutamate entry into Cell and also Norepinephrine levels.
      STUDY: https://www.ncbi.nlm.nih.gov/pubmed/15477382

      ...Also it blocks NMDA-Receptors at a level that would not impair Cognitive Function.
      STUDY: https://www.ncbi.nlm.nih.gov/pubmed/22261381

      It can also reduce GLUTAMATE *RELEASE* In General.
      STUDY: https://www.ncbi.nlm.nih.gov/pubmed/11725166

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  9. High glutamate level in brain cause derealization/depersonalization, anhedonia, anxiety with intrusive existential and suicide thought?

    ReplyDelete
    Replies
    1. It could Yes...by Igniting/Increasing the "Sympathetic Stress Response" thus causing High Cortisol, High ACTH, High Beta-Endorphin and such. This would be Similar to (eventually) Causing "Adrenal Burnout".

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    2. OK. I have persistant derealization depersonalization with intrusive existential and suicidal thought with anhedonia. My cortisol is middle level but I very adverse react to adrenergic antideppressant like venlafaxine, clomipramine, bupropion and reboxetine.This drug exagerrated my symptoms and provide to heavy erectile dysfunction and chronic panic attack and paranoid behaviors. My depersonalization is drug induced- risperidone ( I got it on my chils hyperactivity, talkative personality). This drug destroyed my life.

      Delete
    3. Risperidone is Trash for hormones. You probably have High PROLACTIN levels. Have you had those Hormones checked? If adrenergic-stuff makes you worse, and you have all these Affective Symptoms, its likely you have a Testosterone deficiency and Pregnenolone deficiency.
      See Here Our Article on Testosterone-Adrenaline Sensitivity: https://area1255.blogspot.com/2018/06/testosterone-and-stimulant-sensitivity.html

      ***Things for You To Do***
      Ask Your Doctor/General Physician (GP) or Psychiatrist; whoever you think will Prescribe the Test or go to a Certified Endocrinologist - or Order Online from Life Extension (A Male Hormonal Panel).
      --> Test Serum/Blood/Urine Prolactin (PRL) Levels.
      --> Test Total and Free Testosterone Levels.
      --> Test Thyroid Hormones (TSH/T4/T3)
      --> Test Pregnenolone Levels.
      --> Test DHEA-S (DHEA-Sulfate) Levels.
      --> Get General Blood Work and BLOOD SUGAR TEST.

      Once you do this...we can Figure out where to go from there.

      ...How much Vitamin D do you take? If you OVERDOSE or use TOO MUCH Vitamin A or D - it can CAUSE Depersonalization.

      Any other abnormality?

      You can try using Mucuna Pruriens (40%) L-Dopa to help relieve some symptoms: https://amzn.to/2KBCjhS

      Then I would say include InfoWars "Brain Force" (nootropic) to reboot Proper Memory/Cognition and restore feelings and Balance of Calm: https://amzn.to/2KAddzy

      Lastly, you should supplement with a high-quality Organic multi-vitamin with *ALL ESSENTIALS* and Extra's: https://amzn.to/2u6NBiX

      Delete
    4. I do not have the rest yet but i have this:
      TSH; 2,25
      Free testosterone: 26.6
      Prolactin:6,1
      I'm took risperidone almost 10 years ago. I had 10 years boys- this drug induced derealization-depersonalization with very intrusive thought suicidal and infinity-finity theme. For example- world is flat and poor, life does not make sense, strong hopelessness and my new idea will end , haircuts will depleted and finities , new idea of clothes will depleted, water in ocean will depleted and this catastrophical intrusive ,,matrix" like thought. World perception is very limited, creepy and empty, constant feeling of dangers in the form ,,depletion" all ideas and resources and 100% lack of pleasurness, very quickly boredon and constant panic attack my heart rate is over 100 ( sometimes 130) This illnes from return time to time :(.

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    5. Actually i'm with strong epizode this mental illnes ( derealization+depersonalization wtih contant ,,depletion" theme thought) Previous shorter epizodes recovered from: carbamazepine+tianeptine or carbamazepine+selegiline. Carbamazepine is antiseizure and anxiolitic anti panic and slighty sedative, that's why added tianeptine and selegiline in low dose ( i adverse react for mao a like moclobemide) Selegiline is weak helped my social phobia ( i have very strong and panic). Carbamazepine in high dosage in long time completely helped my previous episode od derealization depersonalization. Actually epizod is longer and very strong. Other drug which i took is clomipramine- induced depersonalization in good period from 2015+ induced dysdhoria and panic+ insomnia. Venlafaxine- the same as clomipramine- worseded my depersonalization and horrible increased anxiety, almost paranoid and psychotic- fell like old horror movie from 80's. Reboxetine and bupropion- stronger and exagerrated version on venlafaxine and clomipramine. Escitalopram- worsened. Antihistamines- very worsened and induced dellirium/insomnia with nightmarres to me. Benzodiazepines- slight better but sedative with very worsened next day-increased panic and suicidal thought. I actually on agomelatine- probably improved my sleep but my depersonalization-derealization, this anxious thought they are strangely long and all the time. Probably melatonin agonist from agomelatine worsened my symptoms, pure melatonin worsened my derealization.

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  10. This comment has been removed by the author.

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  11. the problem is that there are different states of success of glutamate there are mild moderate and strong in itself when it is mild no note there are memory problems and begins to suppress dapomina and gaba there apathy and anxiety. moderate state begins to damage the neurons and there are problems of memory and cognition the dapomina is strongly suppressed the glutamate receptors are hyperactive increasing the voltage of the channels of calcion to exsecivos levels and the doctors do not know what goes through the high degree of apathy and cognitive problems and anxiety and start to supply ritalin methylphenidate and clonazepan but in this degree there is already a strong tolerance the drugs do not effect because the excessive level of glutamate suppresses the expulsion of dopamine and gaba in the brain this is tolerance and severe phase there are combuciones the glutamate controls the dopamine and gaba and is toxic to excessive levels I recommend treating but not with memantine that can generate a catatonic effect if the glutaminergic route collapses dxm is not bad ketamine the worst option the best options are magnesium threonate pregabalin lamotrigine amantadine mynocycline

    ReplyDelete
  12. Do
    Any
    B vitamins come
    Into play negatively with someone that is high glutamate?

    ReplyDelete
    Replies
    1. Possibly too little Vitamin B6 & B12 and TOO-MUCH Thiamine (Vitamin B1). I would expect Sulbutiamine to also react *NEGATIVELY* with you As-Well!!!
      https://www.ncbi.nlm.nih.gov/pubmed/16687165
      REFERENCE 1: https://www.ncbi.nlm.nih.gov/pubmed/16687165
      REFERENCE 2: https://www.ncbi.nlm.nih.gov/pubmed/9249572
      REFERENCE 3: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/

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