In my quest to find natural norepinephrine transporter inhibitors - AKA NorAdrenaline reuptake inhibitors AKA natural NET Inhibitors - I have come across three easily obtainable "remedies" that also have a fair amount of LEGIT, unquestionable science behind them.
But real quickly , why would one want a norepinephrine inhibitor, and not a dopamine reuptake inhibitor, or serotonin reuptake inhibitor?
In order to explain cognition-enhancing effects of standardized Ginkgo biloba extract (EGb761), an increase of central monoaminergic neurotransmission has been suggested, but the underlying mechanisms have not yet been elucidated. Here, we confirm that the norepinephrine (NET), the serotonin (SERT), the dopamine (DAT) uptake transporters and MAO activity are inhibited by EGb761 in vitro, although rather high concentrations are required for inhibition of MAO-A and MAO-B activity. However, after 14 days of daily oral treatment with 100mg/kg EGb761 only NE uptake is significantly decreased in NMRI mice, while 5-HT uptake and MAO activity are not affected. As synaptic dopamine clearance in the frontal cortex is mediated by NET, not DAT, these findings may give an explanation for the enhancement of dopaminergic neurotransmission by EGb761 seen in animal models, presumably linked to its positive effects on cognition and attention.
But real quickly , why would one want a norepinephrine inhibitor, and not a dopamine reuptake inhibitor, or serotonin reuptake inhibitor?
- Norepinephrine is a form of adrenaline, thus if you have low blood pressure - it may be one part of one means to increase it.
- NorAdrenaline can be made more efficient by increasing it's activity; and thus can be a side-kick to a formidable natural anti-depressant.
- Norepinephrine (NORadrenaline) is involved in attentiveness to detail, in particular lights, smells and colors.
- Low levels of norepinephrine often result in "depressive like symptoms" with sensory deficiency and low enthusiasm / quality of life.
- Rasing the activity of norepinephrine may improve energy levels and treat SOME** ADD symptoms and may help to counter the lethargy associated with many anti-psychotic/mood stabilizing drugs.
- It may help in increments to restore normal visual processing capacity, naturally!
The first natural norepinephrine reuptake inhibitor would be ginkgo biloba extract; however, it is not purely so - it also antagonizes GABA-A and affects receptor expression across the board. Mainly influencing the 5-HT1A receptors (preventing loss of) and increasing muscarinic receptors if they are decreased by age.
Pharmacol Res. 2009 Jul;60(1):68-73. doi: 10.1016/j.phrs.2009.02.012. Epub 2009 Mar 21.
Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment.
Abstract
- PMID:
- 19427589
- [PubMed - indexed for MEDLINE]
- MY RECOMMENDED GINKGO BILOBA EXTRACT PRODUCT IS BELOW
The Second natural NORADRENALINE REUPTAKE INHIBITOR ; PSORALEA CORYLIFOLIA!
"This one is a real gem, with additional dopamine reuptake inhibiting properties and listed as an MAO-Inhibiting herb."
It's mentioned on a discussion forum called "DR.BOB" and reiterated as the new "god-tier herb" and future phenomenon on longecity!
http://www.dr-bob.org/babble/alter/20090727/msgs/924490.html
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http://www.longecity.org/forum/topic/45332-psoralea-corylifolia-a-soon-to-be-herbal-phenomenon/
Cell Mol Life Sci. 2009 May;66(9):1617-29. doi: 10.1007/s00018-009-9030-9.
In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta 3,2-hydroxybakuchiol isolated from Psoralea corylifolia (L.).
Abstract
- PMID:
- 19322517
- [PubMed - indexed for MEDLINE]
Behavioral and biochemical studies of total furocoumarins from seeds of Psoralea corylifolia in the forced swimming test in mice
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