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Thursday, February 26, 2015

The Acceptance and Necessity of A Modified Interleukin-15; A Novel Non-Hormone Anabolic & Powerful Synergist of IGF-1

This article has been exclusively written for TrueLIFE Research - and to foster further progress within research of INTERLEUKIN-15 & other novel anabolics, cytokines and anti-aging compounds.

Interleukin-15 is a complex cytokine (with structural similarity to IL-2) and growth factor that plays a huge role in skeletal muscle health and immunological responses.  IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine also induces cell proliferation of natural killer cells; cells of the innate immune systemwhose principal role is to kill virally infected cells. 

 It was discovered, cloned and characterized in 1994; being identified in human cultures/tissues and since then has been the subject of many important research advancements due to it's progressively astounding ability to impact many venues of human health(1).

It drew much attention in 1995; wherein an endocrinology report demonstrating it's application in skeletal myogenesis and myoblast proliferation, led to it ultimately being seen as a novel and potent non-hormonal anabolic "growth factor"(2) (3).

Continuous research also revealed INTERLEUKIN-15; to enhance immune responses and allow cells to more effectively battle the malaria virus, as well as other invaders/pathogens(4)(5).

1994 marked an important take-off and acceleration point for the study of IL-15; it was shown to increase natural T-killer cell production and efficiency, specifically in hunting abnormal cell developments (as in cancer).(6)

A 2011 study also elaborated on IL-15's ability to increase system t-Cell responses against foreign and abnormal cell collections, it was able to mediate an increased response to T-cell lymphomas and thus was seen as being a possible candidate for cancer research and treatment(7).

IL-15 also has shown the ability to modulate epidermal (skin, skin cells) immune cells/proliferation  and possibly reverse dermatitis and contribute to the natural blockade of epidermal invaders(8),
It is also extensively being studied in autoimmune conditions such as multiple sclerosis and in inflammatory bowel disease - where it shows some promise in alleviating these conditions, at least partly, or in some instances, in combination with other treatments(9).

As a further confirmation, IL-15 was again shown to have anabolic and myotropic effects in skeletal muscle - in this particular study - revealing the mechanism of action being antagonizing/halting proteolysis in muscle cells/tissues.

As a result of growing interest around this cytokine, and optimistic scientists in many instances recanting or bringing up IL-15 as a highly symbolic reference amongst anabolic research(10) (11), especially given the incline and attention to muscle wasting disorders, forumer's and fitness enthusiasts have taken further discussions regarding IL-15, under their wing and in highly popular threads(12)(13).

Certainly, and unlike other compounds in which may have questionable, or controversial support, IL-15 remains a candidate more likely to head the spotlight in anabolic research that doesn't involve hormones, or testosterone derivatives. Concern is mounting as many testosterone therapy clinics receive increasing scrutiny, and IL-15 is posed, quite reasonably as a powerful additive or alternative anabolic agent(14).

Particularly in unprecedented synergism with IGF-1 (Insulin-Growth-Factor-1) - where the combination of IL-15 & IGF-1 is noted to result in 5x the Anabolic Effects!!! (15) (16)

THE NECESSITY OF Chemical Modifications In Order to Make IL-15 More Potent and Extend it's Half-Life in Order to Reach a new Level of Progression and Feasibility in Research and Practical Application
Despite all of these benefits, the half-life and bioavailability factors of ordinary IL-15; cause it to remain somewhat inferior to other compounds aiming to dominate the particular venue of interest. This then necessitates a need for an extensive modification  in order for it to be plausible and significant in further scientific application and in practical use involving human subjects/volunteers(17) (18).

Under normal circumstances, this particular innovation would not have been brought to the table - however, Team TLR (Team TrueLife Research) has developed a modified and "optimized" IL-15; code named;                                      -----------------MOD-rhIL-15.-----------------

This is a proprietary modification that enhances it's potency by 125% and enhances the half-life by 290%.

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