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Thursday, October 22, 2015

Symptoms and Signs of LOW Acetylcholine Levels in the Brain and Body (All Sourced; No Junk Science/Bro-Science Here) Low AcH symptoms : Easy to Understand

cetylcholine is a neuromodulating neurotransmitter or neuroregulating transmitter. In simple terms; it is a nerve cell that relays messages and in specific, helps to 'control' the amount of information that is relayed by other nerves...increased AcH (Acetylcholine) allows for neuronal 'bridging' and synaptogenesis; to an extent...but it's most prominent role is in maintaining clarity and homeostasis (balance) in neuronal systems. Acetylcholine also affects hormone production - it can either increase or decrease the HPA-axis, depending on the receptor binded to. It interacts with stress hormones - can increase or decrease ACTH levels and plays a role in gonadal hormone formation (sex hormones, neurosteroids etc).

As such, very low levels often result in distorted array of neurotransmitters and hormones; the hypothalamus either becomes over-active or under-active...most commonly over-active. However, both biological paradigms are possible.

Low Levels of Acetylcholine lead to over-active sympathetic nervous activity; which means adrenaline/noradrenalin excess - this helps to explain the neurosis, mania and other bizarre behaviors that occur when AcH levels become deficient. Low Acetylcholine may also lead to risky or reckless behavior; since the person tends to think 'less' or not think their actions all the way through....

Super high levels of Acetylcholine on the other hand lead to possible brain fog or alterations in cognitive function - mainly because of an existing dopamine opposition by excessive cholinergic inputs - in other words, super SUPER high acetylcholine can reduce the basal and stimulated firing rate of contrast to this - acetylcholine may also boost and / or augment the effects of stimulants. On average, acetylcholine should be* ideally on the high-end of normal depending on what your goals and genetic threshold are comprised of.

Super high acetylcholine also leads to other odd symptoms; despair and depression may occur - or simply a 'bland' anhedonia...however, again, it depends on the person...acetylcholine tends to oppose glutamate to an extent; depending on what receptors are activated...some nicotinic receptors such as alpha-7's actually increase glutamate..but multiple muscarinic receptors; mainly the M1; decreases glutamate...and some nicotinic receptors share opposite effects..

  • Diminished Long-Term Memory (!)
  • Trouble Remembering People & Events (!) (!)
  • Forgetting where you put your Keys, Remote, and with Directions (one or all may be present) (!) (!)
  • General Disorganized Thinking (!)


  • Impulsivity (!) (!)
  • Mania (!) (!) (!)
  • Over-Animated Posture, hypomanic. 
  • Unusually enthusiastic or eccentric. (!)
  • Grandiosity; egotism. (!)
  • Lack of concentration and frustration with work / school which may manifest as 'ADD' or 'ADHD' (!) (!) (!)
  • Anxiety; social isolation. (!) (!)
  • Tendency to drug abuse; especially alcohol and other depressants. (!)
  • Profuse or persistent Anger, low threshold for Criticism and rejects correction. (!) (!) (!)
  • Obsessive-Compulsive disorder is linked to central acetylcholinergic dysfunction. Nicotinic receptors appear to be irregularly firing and some receptors are nearly -inactive-... (!)
  • Low Acetylcholine May Precipitate Psychotic Symptoms in Patients with Schizophrenia and in itself - may lead to thought disorder development.

                                  GENETIC EXTENSION
  • Schizophrenics seem to have DECREASED Muscarinic M1 and M4 acetylcholine receptor expression as well as DECREASED nicotinic acetylcholine receptor availability; namely beta-2 and alpha-7 receptors. (!) (!) (!) (!)


  • Increased or Rapid Heart Rate (tachycardia)
  • Hearing pulse in head at night.
  • Increased blood pressure.
  • Poor oxygen utilization.
  • Fidgety (hand tremors etc)

Suggestions to Increase Acetylcholine 

  • I don't recommend HUPERZINE-A , it does raise Acetylcholine, but it blocks NMDA-glutamate receptors which shuts out any perceived benefit from the increased acetylcholine in certain brain regions. 
  • There are a multitude of natural AChE inhibitors that prevent the breakdown of Acetylcholine.

If you are looking for an herb that

  1. Boosts acetylcholine by preventing it's breakdown AND also has anti-anxiety properties my recommendation would be Ashwagandha Extract.
  2. Boosts acetylcholine by preventing it's breakdown AND boosts histamine and wakefulness/alertness - I recommend hollarhena antidysenteria which contains Conessine.
  3. Products are also below for your convenience ; first is pro-memory and anti-anxiety - second product is pro-memory and stimulant/pro-alertness.



Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy


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