This article aims to be a sort of opposite to the increasing 5-HT1A-Receptors article - as such, the reasons for decreasing the density/concentration are very different than the reasons for increasing 1A-Receptors.
Whereas agonism of, and increasing the count of , 1A-receptors , is useful for Anxiety and, Depression in some cases, the antagonism and / or decreasing of receptor 1A can potentially improve cognition, and overall acquisition...it may also alleviate sexual side-effects of SSRI's.
Hormones & Factors that reduce the sensitivity of and downregulate 5-HT1A's include.....
Whereas agonism of, and increasing the count of , 1A-receptors , is useful for Anxiety and, Depression in some cases, the antagonism and / or decreasing of receptor 1A can potentially improve cognition, and overall acquisition...it may also alleviate sexual side-effects of SSRI's.
Hormones & Factors that reduce the sensitivity of and downregulate 5-HT1A's include.....
Factors that specifically INCREASE hypothalamus-5-HT release and 5-HT1A-hypothalamic receptors would be.... (ANTI-TARGETS)...
In order to downregulate these Receptors - we need to do two things.
- Increase Free Testosterone; lift weights, lose fat/gain muscle, use stuff like Tongkat Ali. Nettle HP Extract (8) (9) (10) (11) (12)...
- Use Forskolin + Olive Leaf Extract to boost T4/T3 thyroid hormone levels (13) (14)....
Finally, you can also use a modulatory-compound that specifically mimicks estrogen in discrete-regions of the hypothalamus - one that blocks excessive estrogen in the breasts/chest and prostate - but also selectively activates it where it would then influence the post-synaptic densities...in this case, I recommend PhytoSERMs.
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