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Monday, February 1, 2016

What Neurotransmitters Decrease GABA (In Prefrontal Cortex; PFC, Hypothalamus/MPOA/PVN) (Includes Supplement Suggestions)

Perhaps , you want to decrease GABA to create an empathogenic effect (increasing empathy), or perhaps, to increase one's libido, or perhaps, to increase cognition/memory (1) (2). There are tons of reasons one may want to actually DECREASE/INHIBIT GABA in the brain..and believe it or not, there are some who claim ''too little anxiety'' - or perhaps, one is ridded with emotion so much that GABA is their accused culprit. Of course, these are all speculative scenarios...decreasing GABA has never really been proven to increase empathy, but there anecdotal reports and forum based hypothesis (3) (4).

Decreasing GABA though, does have supported applications in.

  • Increasing Dopamine release. (4)
  • Increasing sexual desire.        (5)
  • Increasing Motivation.            (6)
  • Improving Memory.                (7)

Some firm guidelines.

  1. Serotonin and 5-HTP Increase hypothalamic GABA and this contributes to PRL-release and inhibition of libido and hormone secretion by Serotonin (8)
  2. Dopamine D(2) (9) Dopamine D(4) Activation decrease GABA in the VTA and Supraoptic/Magnocellular Area's , respectively (10)
  3. Adenosine A1-Receptors remarkably inhibit Striatal GABA Release (11).
  4. Alpha-2-Adrenoreceptors enhance GABA release and Beta-adrenoreceptors decrease GABA release (norepinephrine/adrenaline receptors) (12)
  5. Alpha-1 Adrenoreceptors reduce GABA in the VTA (13) but also DECREASE it (moreso) in the PVN/Hypothalamus. (14)

Now, here's a good outline of how to use SUPPLEMENTS to DECREASE GABA..

  1. Use Tibetan SHILAJIT Paste to decrease Serotonin activity.
  2. Use GINKGOLD™ ; A Patented Ginkgo Biloba Extract which directly antagonizes GABA-A Receptors...especially in the Hypothalamus (15) (16)  (17)
  3. L-Histidine; which increases HA (Histamine), will decrease HYPOTHALAMUS GABA (18) (19) (20).
  4. Eating FISH (Mackerel, Tuna, Herring, Sprat, Tilapia, Salmon) can increase histamine and the enzyme that helps the body produce it (HDC) (21) (22) (23) (24)
  5. Tadalafil (Cialis) : Is known to improve memory/cognitive function/s and improve the Glutamate:GABA Ratio in the Brain (25).

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