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Wednesday, January 20, 2016

How to DOWNREGULATE (Decrease) Serotonin 5-HT6 Receptors by Supplements & / or Pharmacological Methods

5-HT(6) Serotonin Receptors are GPCR's (G-Protein-Coupled-Receptors) that are positively coupled to adenylyl cyclase/adenylate cyclase which then increases the levels of cyclic adenosine monophosphate (cAMP) (1) and also they enhance the GABAergic signal which leads to inhibition of several neurotransmitters (2)...

  • They markedly decrease cholinergic transmission (acetylcholine) (3)
  • They decrease glutamate levels widespread (4)
  • They decrease dopamine in the frontal cortex and limbic areas (5).
  • They exert differential regulation patterns in the medial amygdala and thalamus however, they play little role in HUMAN endocrine functions despite their positive role in the production of cAMP (6) (7) (8).

Thus, decreasing the number of (downregulating) these ((5-HT6)) Receptors will IMPROVE Memory, Mood, Motivation and general mental integrity by all-round improving neurotransmission in almost every brain region.

5-HT6 Serotonin receptors are regulated by TWO Primary mechanisms.

The EASIEST way to address BOTH of these issues is to use ANIRACETAM, a nootropic supplement of the 'Racetam' class; this will downregulate 5-HT6 by the glutamate pathway. 

ANIRACETAM can be purchased @

The next SECRET is to DOWNREGULATE or otherwise BLOCK ESTROGEN Activity/Level's as Estrogen interacts with the corticosteroid pathway and also stimulates 5-HT6-receptor Activity (13) (14).

  • Check hormone levels in blood work to make sure Estrogen (E2) isn't already low.
  • Check out Arimidex; the only proven way to decrease estrogen significantly in both men and women.
  • ANOTHER REASON for Men to NOT LET Estrogen run rampant in their bodies!!

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