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Thursday, January 21, 2016

Methiothepin - Mechanism of Action / Pharmacology / Binding Profile (Area-1255:RC/OD Listings)




METHIOTHEPIN BINDING PROFILE {ACTIVITIES}
  • 5-HT1 Antagonist w/ Highest Affinity for 5-HT(1)B/D Receptors (1) (2).
  • 5-HT2 Antagonism (Potent @ 2A/2B/2C, but lesser than type 1B/1D) (3) (4)
  • Alpha-1-Adrenergic (Adrenaline) Antagonist  (possesses vasodilating properties) (5)
  • STRONG Dopamine D(2) Antagonist (displaying anti-psychotic properties/actions) (6) (7)
  • STRONG Anti-Histamine (H1-Selective; Producing Sedation, limiting usefulness in cognitive paradigms) (8) (9) (10) 
  • Lesser, but significant affinity for 5-HT(6/7) Receptors (11) (12) (13) (14)



Methiothepin Specific Interactions

1 comment:

  1. it also antagonises the 5-ht1a autoreceptor!
    http://www.ncbi.nlm.nih.gov/pubmed/2869415
    Do you have a source to buy??

    ReplyDelete