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Sunday, January 31, 2016

The NeuroPharmacology of Copper (Copper and Neurotransmitters / Release) Copper Mechanism of Action in the Brain

Copper (Cu) is an essential trace mineral and common metal whose ions permeate the blood-brain-barrier and exert multiple actions on receptors and brain proteins...

  • Copper (Cu) acts to noncompetitively inhibit/antagonize/block NMDA-Glutamate Receptor Currents. (1)
  • Copper plays a primary role along with Ascorbic Acid in converting Dopamine --> Norepinephrine. (2)
  • Copper stimulates the Adrenal Gland's. (3)
  • Copper augments Acetylcholine activity. (4)

Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders

Copper deficiency alters rat dopamine beta-monooxygenase mRNA and activity.

Effect of antipsychotic drugs on the gene expression of NMDA receptor subunits in rats.

Role of copper in human neurological disorders

  • Copper and Copper Proteins in Parkinson's Disease


Effect of ascorbic acid administration on copper-induced changes of rat brain hypothalamic catecholamine contents.

Analysis of Copper and Zinc Plasma Concentration and the Efficacy of Zinc Therapy in Individuals with Asperger’s Syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and Autism

Effect of dietary copper deficiency on the distribution of dopamine and norepinephrine in mice and rats.

Copper modulation of NMDA responses in mouse and rat cultured hippocampal neurons.

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