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Saturday, November 7, 2015

Mechanism of Action/Pharmacology of Terminalia Chebula (Haritaki) ~ Also Goes Over (Terminalia Chebula effect on Neurotransmitters)



Terminalia Chebula (Haritaki) is an Adaptogen with multiple mode's of action. It is an Ayurvedic herb discussed by many practicing Medical Experts (1) (2) in many countries. Not just India. Adaptogen means it increases the body's ability to adapt to various stressors and maintain bodily homeostasis (balance of functions, a healthy state, harmony of systems). 

Terminalia Chebula is PRIMARILY an anti-bacterial agent but it has some other fascinating characteristics.





     NEUROLOGY 
(Terminalia Chebula Effect on Neurotransmitters) 

Terminalia Chebula is shown to have an anti-Epileptic effect. The specific quote from the paper referenced is the most meaningful. 


The extract was also shown to delay the latency of pentylenetetrazole and picrotoxin induced seizures, suggesting that the extract exhibiting anticonvulsant affect, probably by opening the chloride channels associated with GABA receptors. Thus, in conclusion, T. Chebula possesses anticonvulsant property against the MES, PTZ and PC induced seizures. From the above result, further investigation is warranted in order to isolate and identify the specific molecules which are responsible for the anticonvulsant activity.

    TERMINALIA CHEBULA As An ANTI-STRESS TONIC and  Natural Anti-Depressant


 Terminalia Chebula can also reverse stress-induced biochemical changes including stress-induced cortisol release {see reference paper here or click image below } . This essentially means it can protect against psychological stress and promote adaptation to environmental stressors. 





                                       
    TERMINALIA CHEBULA BENEFITS MEMORY



Terminalia Chebula may be able to terminate parasites by interfering with their motor coordination as evidenced in it's ability to inhibit AChE enzymes within livestock (!) ; the acetylcholine promoting activities may also contribute to Terminalia's pro-kinetic (enterokinetic, promotes passing of stool) and may underlie some of it's memory enhancing effects. Terminalia has been confirmed to not just inhibit AcHe in the gut but in the brain as well (see here).

Terminalia may also interact with NMDA receptors and modulate hippocampal plasticity and enhance spatial memory. (see study/paper here)







   **OTHER MAIN REFERENCES FOR THIS SEGMENT**


ROLE OF TRADITIONAL MEDICINE IN NEUROPSYCHOPHARMACOLOGY

Studies on Chebulinic Acid Extraction from Terminalia chebula species

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

PATENT : Natreon Inc :: Terminalia chebula compositions and method of extracting same 



    TERMINALIA CHEBULA As an Erectile Tonic / Possible Natural Treatment for Erectile Dysfunction 

Terminalia was one of several plants screened for RHO-KINASE inhibiting properties (!) ; natural ROCK-II inhibitors show efficacy in treating some forms of vascular erectile dysfunction.


Additionally, it was mentioned in this paper as a candidate for treatment in a more formal medical context.

Now while there hasn't been a huge amount of study with that enzyme in particular in contrast to other more 'known' enzyme targets like PDE-5A and such - it does seem to be a centrally mediator in penile flaccidity and may be the 'end-point' in which some neurotransmitters create their constricting effect (!) (!)


               OTHER REFERENCES FOR THIS SECTION




My recommended brand of this particular herb is below for your convenience. It's the ONLY brand which I trust for a variety of reasons... not just because it's 'organic' but also because the company has an excellent, almost unprecedented track-record in quality customer service and quality products!


                                                                    

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