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Thursday, July 13, 2017

Causes of Tics Disorder & Natural Treatment (Neurotransmitter Levels in Tics/Tourettes Syndrome) Easy-List to write down!

Tics disorder is regarded as a milder form of Tourette's Syndrome (TS) and without the vocal symptoms [1]. However, in those affected, the symptoms of Tics can be just as stressful (and embarrassing) [2]. Tics disorder is defined by often multiple forms of motor tics; eye blinking, hand jerking, squeezing motions with the hand and sometimes other forms of muscle tightening and jerking [3]

The main causes of Tics are listed below. 

  • A genetic variant in the histamine-producing enzyme HDC; which leaves the brain with about half of its normal histamine production [4].
  • Too much of the serotonin 5-HT2A-receptor [5].
  • Increased norepinephrine (noradrenaline) [6] and decreased breakdown of norepinephrine [7].
  • Low Acetylcholine levels/activity [8]. Nicotine gum was shown to be effective in some TS-patients so nicotinic acetylcholine-receptors seem to be primarily involved [9].
  • Decreased glutamate activity in certain brain regions such as the substantia nigra pars, globus pallidus interna & globus pallidus externa  [10] [11].
  • Too much Cortisol/HPA responsivity [12].
In addition to that environmental/bodily factors such as...

  1. Stress [13].
  2. Allergen exposure [14].
  3. Infection [15].
  4. Inflammation [16].
  5. Anger/Agitation [17].
  6. Cardiovascular disease [18].
  7. Trauma (mainly head trauma) [19].
  8. Poor diet (too much sugar) [20].
  9. Sleep Deprivation/too little sleep [21] [22] [23].
  10. Chronic Health Issues [24] [25] [26] [27] [28] [29].
***Comments : Even though decreased brain histamine levels tend to be a genetic risk factor in Tics/Tourette's syndromes, you can't ignore the fact that all factors that INCREASE histamine (including stress & allergens) tend to increase Tics symptoms, so my guess is that the brain is also not using the histamine correctly. 

Also, the studies involving histamine-decarboxylase (HDC; the histamine producing enzyme) have not involved 100% of the families with known genetic TS. Therefore it is probable that not everyone has the exact same etiology. 

So to conclude, the reasonable way to treat Tics/Tourette's syndrome (without drugs) would be...

  1. L-Histidine supplementation (to raise brain histamine). 
  2. Metergoline or another serotonin antagonist (technically is a drug, but its safe). 
  3. Sympatholytic agents (things that decrease norepinephrine), possibly Ashwagandha extract because it can calm the nervous system and it also hits acetylcholine (raising it) which can  help with the other imbalances in Tics disorder.
  4. Glutamate is too tricky, but theoretically if low glutamate defines Tics then you could look into Glutamine and / or n-carbamyl-glutamate HOWEVER I have not heard of anyone who has had success in raising or lowering glutamate so I tend to think that the glutamate  abnormalties reported in Tics patients are more related to the decreased histamine and the issues with interneuron activity.
***Other Comments : Serotonin is not a guaranteed target, however since antipsychotic drugs that block serotonin receptors have proven efficacious in Tics disorder - it seems likely that this is the way to go. I'm not sure if lowering serotonin in general would help Tics, since it is ONLY the 5-HT2A-receptor that is abnormally elevated in Tics disorder.


Histamine control of Tourette syndrome (MedicalExpress Magazine)

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  1. Also
    Dopaminergic receptor D5 mRNA expression is increased in circulating lymphocytes of Tourette syndrome patients.

    Glutamatergic drugs exacerbate symptomatic behavior in a transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder.

    Altered monocyte activation markers in Tourette’s syndrome: a case–control study

    @This cure / cause is not commonly spoken of because if will effect the medical and dentistry industry quite a bit. As mercury is used in not only mercury fillings but in vaccinations and other products (like contact lens solution etc etc). I went through a mercury detox program, had my fillings removed (by a special dentist) and replaced with non-mercury amalgam fillings, I no longer took vaccinations (I also noticed my symptoms got worse after vaccinations) and surprise surpise - MY TOURETTES IS GONE. @

    Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, tourette's syndrome, and healthy controls

    Chronic, multiple tics of Gilles de la Tourette's disease. CSF acid monoamine metabolites after probenecid administration.

    A study of clinical pictures and monoamine metabolism of Gilles de la Tourette syndrome

    Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis.

    Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder.

    Cerebellar morphology in Tourette syndrome and obsessive-compulsive disorder.

    Methods of treating tardive dyskinesia and other movement disorders

    1. Interesting. So the D5-cAMP-Ca2+ cascade seems to be principle. Everything here you presented is Great! Thank You Kpavel. :)


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